Five-Year Survival Rates and Time Trends of Laryngeal Cancer in the US Population

Cosetti, Maura K.; Yu, Guo-Pei; Schantz, Stimson P.

doi:10.1001/archotol.134.4.370

Cited by 124 publications

(120 citation statements)

References 18 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…Most patients who had samples with >4% ACs were heavy smokers (P ¼ .044), which correlates well with the finding that smoking is related directly to laryngeal cancer development. [1][2][3][4] The 4% cutoff point also was tested on a limited number of post-SCC patients who had clinical findings that were suspicious for recurrence. Although those results were not statistically significant, patients in that group who were diagnosed histopathologically with carcinoma had >6.7% ACs compared with <4% ACs in the 3 patients who were diagnosed with nondysplastic lesions.…”

Section: -41mentioning

confidence: 99%

“…[1][2][3][4] It is believed that squamous cell carcinoma (SCC), which comprises >90% of laryngeal malignancies, progresses through a series of well defined clinical and histopathologic stages in the form of precursor lesions with various degrees of dysplasia. [5][6][7] Clinically, these lesions appear mainly along the true vocal cord as white exophytic or shallow patches (leukoplakia).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Noninvasive detection of aneuploid cells in laryngeal epithelial precursor lesions

Shani

Primov-Fever

Wolf

et al. 2011

Cancer Cytopathology

View full text Add to dashboard Cite

BACKGROUND:Most cases of laryngeal cancer are preceded by precursor lesions which, if left untreated, can progress toward an invasive cancer. The objective of this study was to investigate the presence of chromosomal numerical aberrations in cells that were collected by noninvasive brush sampling from laryngeal lesions.METHODS:Laryngeal brush samples from 52 patients were analyzed simultaneously for morphology and fluorescence in situ hybridization (FISH) using centromeric probes for chromosome 17, chromosome 8, and a locus‐specific instability (LSI) v‐myc avian myelocytomatosis viral oncogene homolog (myc) proto‐oncogene protein (C‐MYC) probe for the MYC gene. The patients were divided according to histopathologic diagnosis. Group 1 included patients with squamous cell carcinoma, carcinoma in situ, and severe dysplasia; Group 2 included patients with moderate dysplasia, mild dysplasia, and hyperplasia; and Group 3 included patients with benign nondysplastic lesions.RESULTS:The proportion of cells with MYC and chromosome 8 gains demonstrated significant trends toward being the highest in Group 1 and the lowest in Group 3 (P = .001 and P = .003, respectively). No significant trend was observed for chromosome 17. Mann‐Whitney Bonferroni‐corrected analyses revealed that the most significant contribution was the difference between Groups 1 and 3 (P = .0195 for MYC gains and P = .036 for chromosome 8 gains). When using a cutoff point of 4% aneuploid cells (ACs), both MYC and chromosome 8 differed significantly between groups (P = .030 and P = .037, respectively).CONCLUSIONS:The current results suggested that FISH analysis of brush samples obtained noninvasively from suspicious laryngeal lesions can augment the clinical examination in predicting the nature of the lesions and can aid clinicians in monitoring and follow‐up of high‐risk patients. Cancer (Cancer Cytopathol) 2011. © 2011 American Cancer Society.

show abstract

Section: -41mentioning

confidence: 99%

mentioning

confidence: 99%

Noninvasive detection of aneuploid cells in laryngeal epithelial precursor lesions

Shani

Primov-Fever

Wolf

et al. 2011

Cancer Cytopathology

View full text Add to dashboard Cite

show abstract

“…Despite advances in the development of conventional therapies such as surgery, radiotherapy and chemotherapy, the 5-year survival rate for patients with LSCC remains unsatisfactory (~50-70%) (2). Locoregional recurrences, lymph node and distant metastasis are major causes of death that significantly affect prognosis in LSCC patients (3). Therefore, the recognition and identification of tumor markers associated with recurrence and/or metastasis is of great value in the prediction of malignant biological behavior and the direction of therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Tiam1 promotes the progression of laryngeal squamous cell carcinoma

Wang

Tang

et al. 2015

Oncology Reports

View full text Add to dashboard Cite

Abstract. T-lymphoma invasion and metastasis-inducing factor 1 (Tiam1) has been reported in various types of human cancer, which play important roles in facilitating the metastasis of malignant tumor. However, the investigation of Tiam1 in laryngeal squamous-cell carcinoma is extremely rare. The aim of the present study was to assess Tiam1 expression and examine its function in tumorigenesis and the metastasis of laryngeal squamous cell carcinoma (LSCC) in vitro. Tiam1 expression in 98 primary LSCC tissue specimens was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patients' survival. To investigate the effects of Tiam1 on the progression of LSCC, Tiam1/C1199 plasmid was transfected into LSCC, and proliferation, apoptosis, migration and invasion of transfected cells were examined using MTT, flow cytometry, wound-healing and Transwell assay, respectively. The results showed that, Tiam1 was detected in all primary LSCC samples. Additionally, Tiam1 overexpression was closely correlated with tumor progression and patient survival. Tiam1 overexpression was statistically significant, and served as an independent predictor of prognosis for patients with LSCC. The upregulation of Tiam1 by Tiam1/C1199 plasmid had no effect on the proliferation of transfected cells, but decreased the apoptotic rate of transfected cells, while the ability of migration and invasion was increased. These results suggested that Tiam1 overexpression in LSCC is possibly involved in the promotion of migration and invasion, and is a promising therapeutic target in the prevention of the progression of LSCC.

show abstract

“…Current treatments, including surgical intervention, radiation therapy and chemotherapy, have a moderate effect on early-stage cases, but are less effective in more advanced cases. Five-year overall survival for supraglottic cancer remains poor (2,3). Therefore, understanding the molecular pathways of carcinogenesis or progression is key to improving diagnosis, therapy and prevention of supraglottic carcinoma.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA expression profiles in supraglottic carcinoma

et al. 2014

View full text Add to dashboard Cite

Abstract. MicroRNAs (miRNAs) are single-stranded RNA molecules which regulate gene expression at the post-transcriptional level and several miRNAs have been found to be associated with some types of cancer. We sought to identify the expression and involvement of miRNAs in supraglottic carcinoma tissues compared with normal tissues and to determine whether miRNA expression is predictive of disease. Unsupervised clustering shows that miRNA profiles can distinguish tumor from normal tissues. Analysis of miRNA contents in supraglottic carcinoma highlighted nineteen differentially expressed miRNAs, three upregulated miRNAs (miR-21, miR-19a, miR-33a) and two downregulated miRNAs (miR-206, miR-375). The microarray results of supraglottic carcinoma and related computer analysis may be beneficial for further analysis of cancer diagnosis and therapy. IntroductionLaryngeal squamous cell carcinoma (LSCC) is a very common malignant neoplasm of the head and neck. One of the key challenges in the treatment of LSCC is the management of metastasis to locoregional lymph nodes. Lymph node metastasis is common in supraglottic carcinoma and is the main cause of mortality for these patients. It has been reported that the incidence of lymph node metastasis may be as high as 25-50% in supraglottic carcinoma (1). Current treatments, including surgical intervention, radiation therapy and chemotherapy, have a moderate effect on early-stage cases, but are less effective in more advanced cases. Five-year overall survival for supraglottic cancer remains poor (2,3). Therefore, understanding the molecular pathways of carcinogenesis or progression is key to improving diagnosis, therapy and prevention of supraglottic carcinoma. microRNAs (miRNAs) are a class of small, non-coding RNAs that are endogenously expressed in animal and plant cells. They regulate the expression of protein-coding genes at the translational level. One strand of the mature double-stranded miRNA is incorporated into the RNA-induced silencing complex, which downregulates target mRNAs either by degradation or by translational inhibition (4). miRNAs play important roles in normal regulation of gene expression for developmental timing, cell proliferation and apoptosis. Moreover, altered miRNA expression is implicated in cancer. Recently, miRNA genes were implicated in several types of cancer (5-7). The expression of miRNAs varies between cancer and normal cells and it also varies among different types of cancer. It has been shown that some miRNAs are aberrantly expressed in several different types of cancer (8-10), suggesting that they may play a role as a novel class of oncogenes or tumor-suppressor genes.Several target genes have been experimentally identified for some miRNAs in various LSCCs; however, the global pattern of cellular functions and pathways affected by miRNAs in supraglottic cancer remains elusive. In the present study, expression profiling of miRNAs in clinical supraglottic carcinoma tissue samples was carried out, revealing the relationship between miRNA exp...

show abstract

Five-Year Survival Rates and Time Trends of Laryngeal Cancer in the US Population

Cited by 124 publications

References 18 publications

Noninvasive detection of aneuploid cells in laryngeal epithelial precursor lesions

Noninvasive detection of aneuploid cells in laryngeal epithelial precursor lesions

Overexpression of Tiam1 promotes the progression of laryngeal squamous cell carcinoma

MicroRNA expression profiles in supraglottic carcinoma

Contact Info

Product

Resources

About