Five Years' Experience Treating Locally Advanced Cervical Cancer With Concurrent Chemoradiotherapy and High-Dose-Rate Brachytherapy: Results From a Single Institution

Initial Report of Pencil Beam Scanning Proton Therapy for Posthysterectomy Patients With Gynecologic Cancer

“…Several randomized studies have demonstrated an overall survival and locoregional control benefit by the addition of concurrent chemotherapy to radiation therapy in women with locally advanced cervical cancer (2)(3)(4). The inability to deliver all intended chemotherapy can result in inferior outcomes, which has been previously demonstrated (4,5).…”

Risk assessment model for overall survival in patients with locally advanced cervical cancer treated with definitive concurrent chemoradiotherapy

“…To analyze the prognostic variables for overall survival, the following factors were included because previous studies have shown they may have some prognostic value [12][13][14][15][16][17]: age, FIGO stage, histological type, tumor size, parametrial involvement, pelvic lymph node metastasis, paraaortic lymph node metastasis, pretreatment serum SCC Ag, pretreatment hemoglobin, hydronephrosis, and bladder or rectal invasion. The tumor size, the parametrial involvement, and the pelvic/paraaortic lymph node metastases were determined by MRI.…”

“…However, it has been shown that the survival of individual patients with the same stage of disease varies [11,12]. Furthermore, other prognostic factors that are not included in FIGO staging system have been identified [13][14][15][16][17]. Therefore, to predict individual prognosis more accurately, it may be necessary to consider prognostic factors other than FIGO stage alone.…”

Long-term results and prognostic factors of patients with cervical carcinoma treated with concurrent chemoradiotherapy

“…Before the publication of the randomised studies by the NCI, the role of chemoradiation in advanced carcinoma of the cervix had already been evaluated in various meta-analyses and systematic reviews, confi rming the superiority of chemoradiation [7,8]. Further studies have shown that this modality of treatment improves overall survival and progression-free survival, although there is an increase in acute gastrointestinal and haematological toxicity [2,[9][10][11][12][13]. However, data on late toxicity are scarce [14].…”