2008
DOI: 10.1200/jco.2008.26.15_suppl.16034
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Five years survival and risk of death in a phase III study of intermmittent monotherapy versus continuous combined androgen deprivation

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“…The design of IAS studies has varied substantially; for example, employing GnRH agonists with or without a nonsteroidal antiandrogen, on-treatment cycles lasting 3–9^months, and different triggers for initiation of subsequent cycles 49. Several trials, including various phase II studies and interim analyses of phase III trials, suggest improvement in terms of quality of life, cardiovascular events and osteoporosis, among other benefits, with IAS 52,53. Rates of overall survival and progression to CRPC seem to be equivalent to those seen with continuous therapy, according to several phase II trials and early phase III data 18.…”
Section: Contemporary Approaches To Androgen Deprivation Therapymentioning
confidence: 99%
“…The design of IAS studies has varied substantially; for example, employing GnRH agonists with or without a nonsteroidal antiandrogen, on-treatment cycles lasting 3–9^months, and different triggers for initiation of subsequent cycles 49. Several trials, including various phase II studies and interim analyses of phase III trials, suggest improvement in terms of quality of life, cardiovascular events and osteoporosis, among other benefits, with IAS 52,53. Rates of overall survival and progression to CRPC seem to be equivalent to those seen with continuous therapy, according to several phase II trials and early phase III data 18.…”
Section: Contemporary Approaches To Androgen Deprivation Therapymentioning
confidence: 99%