Fixation Frame for Electronystagmography in the Rat

Fischer, Ann-Christin; Kuijpers, W.; Huygen, P.L.M.

doi:10.1159/000275485

ORL

1980

DOI: 10.1159/000275485

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Fixation Frame for Electronystagmography in the Rat

Ann-Christin Fischer¹,

W. Kuijpers²,

P.L.M. Huygen³

Abstract: This communication describes the design and method of use of an adjustable fixation frame especially designed to immobilize rats for experimental electronystagmography.

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1983

1985

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Physiological Abnormalities in Experimental Allergic Encephalomyelitis (EAE):I. Vestibular Hyperreactiuity (VH) in Rats with EAE

Huygen

Brinkman

1983

Acta Oto-Laryngologica

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Twelve Lewis rats were inoculated with a guinea pig spinal cord tissue preparation. They developed experimental allergic encephalomyelitis (EAE) after 12-14 days, manifested by weight loss, tail flaccidity, ataxia, hind limb paresis and incontinence. The CNS lesions are produced in this animal model on the basis of inflammatory demyelination, which provides a useful model for multiple sclerosis. Concomitantly with EAE, all animals developed vestibular hyperreactivity (VH) of otolith and canal reflexes. In surviving animals these reflexes renormalized after full clinical recovery. The major effect on the canal response was an increased duration of postrotatory nystagmus caused by an increase in time constant. These findings are similar in part to those previously reported in patients with multiple sclerosis. Acta Otolaryngol Downloaded from informahealthcare.com by McMaster University on 01/05/15For personal use only.

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Physiological Abnormalities in Experimental Allergic Encephalomyelitis (EAE):I. Vestibular Hyperreactiuity (VH) in Rats with EAE

Huygen

Brinkman

1983

Acta Oto-Laryngologica

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Virus-induced Central Positional Nystagmus in Mice

Koolen

Huygen

Calafat

et al. 1985

Acta Oto-Laryngologica

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Geotropic direction-changing nystagmus in lateral body positions was observed in 4-week-old BALB/c mice after intracerebral injection with a temperature-sensitive mutant of mouse hepatitis virus. The positional nystagmus was detected already 2 days after infection and it lasted half a year at least. The nystagmic responses of the semicircular canals were also evaluated before and after infection. They were unaltered during the disease, which was clinically manifested by general weakness, ataxia and tremor. Histopathological examination 2 weeks after infection revealed demyelination in various parts of the CNS.

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Fixation Frame for Electronystagmography in the Rat

Abstract: This communication describes the design and method of use of an adjustable fixation frame especially designed to immobilize rats for experimental electronystagmography.

Cited by 2 publications

References 1 publication

Physiological Abnormalities in Experimental Allergic Encephalomyelitis (EAE):I. Vestibular Hyperreactiuity (VH) in Rats with EAE

Physiological Abnormalities in Experimental Allergic Encephalomyelitis (EAE):I. Vestibular Hyperreactiuity (VH) in Rats with EAE

Virus-induced Central Positional Nystagmus in Mice

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