Fixation Location and Stability Using the MP-1 Microperimeter in Stargardt Disease

Schönbach, Etienne M; Ibrahim, Mohamed; Strauss, Rupert W.; Birch, David G.; Cideciyan, Artur V.; Hahn, Gesa Astrid; Ho, Alexander; Kong, Xiangrong; Nasser, Fadi; Sunness, Janet S.; Zrenner, Eberhart; Sadda, Srinivas R.; West, Sheila K.; Scholl, Hendrik P. N.

doi:10.1016/j.oret.2016.08.009

Cited by 39 publications

(56 citation statements)

References 34 publications

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“…Fixation stability was then quantified as a continuous variable, the BCEA. The BCEA offers clear advantages over categorical biomarkers of fixation stability in STGD1 [18]. The global BCEAs for 1, 2 and 3 standard deviations were calculated using the following equation:…”

Section: Grading Of Faf and Mp Examsmentioning

confidence: 99%

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Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1)

et al. 2018

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Purpose: To describe the study design and characteristics at first visit of participants in the longitudinal Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) study. Methods: Scotopic microperimetry (sMP) was performed in one designated study eye in a subset of participants with molecularly proven ABCA4-associated Stargardt disease (STGD1) enrolled in a multicenter natural history study (ProgStar). Study visits were every 6 months over a period ranging from 6 to 24 months, and also included fundus autofluorescence (FAF). Results: SMART enrolled 118 participants (118 eyes). At the first visit of SMART, the mean sensitivity in mesopic microperimetry was 11.48 (±5.05; range 0.00–19.88) dB and in sMP 11.25 (±5.26; 0–19.25) dB. For FAF, all eyes had a lesion of decreased autofluorescence (mean lesion size 3.62 [±3.48; 0.10–21.46] mm²), and a total of 76 eyes (65.5%) had a lesion of definitely decreased autofluorescence with a mean lesion size of 3.46 (±3.60; 0.21–21.46) mm². Conclusions: Rod function is impaired in STGD1 and can be assessed by sMP. Testing rod function may serve as a potential outcome measure for future clinical treatment trials. This is evaluated in the SMART study.

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Section: Grading Of Faf and Mp Examsmentioning

confidence: 99%

“…P is the chosen probability for the SD that the BCEA is based on, and the equation is solved for k [16][17][18]:…”

Section: Grading Of Faf and Mp Examsmentioning

confidence: 99%

Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1)

et al. 2018

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“…The distance from the PRL to the fovea can be calculated using the coordinates of the PRL centroid. 26,50…”

Section: Fixation Stabilitymentioning

confidence: 99%

Microperimetry for geographic atrophy secondary to age-related macular degeneration

Csaky

Patel

Sepah

et al. 2019

Survey of Ophthalmology

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Geographic atrophy (GA) is a progressive, advanced form of age-related macular degeneration leading to visual function impairment and irreversible vision loss. Standard clinical tests to evaluate visual function in patients with GA provide poor anatomic-functional correlation, whereas fundus imaging does not assess the visual function deficit. Microperimetry is a psychophysical visual function test that spatially maps retinal sensitivity and allows for identification of correlation of anatomic features with visual function. In this review, we present an overview of mesopic microperimetry for GA, including commercially available microperimetry devices, strategies to capture a mesopic microperimetry test, and strategies to assess and interpret microperimetry data in patients with GA. We demonstrate the importance of microperimetry data for assessing GA progression and for evaluating visual function loss through anatomic-functional

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“…Also the fixation stability is worse than foveal fixation . Poor fixation stability is correlated with poor visual acuity and poor reading speed . Studies indicate that individuals adapt typically within six months to using an eccentric locus for fixation, but efficient use of PRL requires extensive training .…”

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confidence: 99%

Visual rehabilitation using microperimetric acoustic biofeedback training in individuals with central scotoma

Ratra¹,

Gopalakrishnan

Dalan

et al. 2019

Clinical and Experimental Optometry

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Background: Patients with central scotoma have poor fixation stability and poor visual acuity. Acoustic biofeedback training can be an effective way to train such patients to eccentrically fixate. This study analyses the mean retinal sensitivity, saccadic velocity, and fixation stability after acoustic biofeedback training and shows correlation with age and scotoma size. Methods: Patients with irreversible central scotoma in both the eyes secondary to macular diseases were selected. After undergoing comprehensive low vision assessment, 19 patients who were willing were recruited for the acoustic biofeedback training to the better eye in 10 sessions, using the MP-1 Microperimeter. Mean retinal sensitivity, saccadic velocity, fixation stability before and after the acoustic biofeedback were recorded. Results: There were 17 men and two women. Ages ranged from 19-94 years (mean 54.63 AE 24.66). The scotoma size ranged from four to 20 degrees. Ten patients had agerelated macular degeneration, four had Stargardt disease, three had traumatic macular scar, two had scarred myopic choroidal neovascular membrane, and one had myopic macular degeneration. The vision improved from 1.06 AE 0.36 to 0.86 AE 0.33 logMAR (p < 0.0001). The mean retinal sensitivity improved from 2.1 AE 2.9 dB to 2.7 AE 3.1 dB (p = 0.01), with negative correlation with age (p = 0.01) and scotoma size (p = 0.02). Fixation stability improved with reduction in the bivariate contour ellipse area (p = 0.01). It showed negative correlation with age (p = 0.02) and scotoma size (p = 0.10). The saccadic velocity reduced from 0.34 /second to 0.26 /second but was not significant (p > 0.99). The majority (58 per cent) had their preferred retinal locus superior to the fovea. There was good agreement between bivariate contour ellipse area and MP-1 Microperimeter inbuilt fixation parameters. The effect was maintained at six months with slight reduction in fixation stability. Conclusion: Acoustic biofeedback can improve fixation behaviour, visual acuity and retinal sensitivity in patients with central scotoma. The results are better with younger age and smaller scotoma size.

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Fixation Location and Stability Using the MP-1 Microperimeter in Stargardt Disease

Cited by 39 publications

References 34 publications

Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1)

Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1)

Microperimetry for geographic atrophy secondary to age-related macular degeneration

Visual rehabilitation using microperimetric acoustic biofeedback training in individuals with central scotoma

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