Fixation sur cellulose de médicaments libérables par voie enzymatique

Lapicque, Françoise; Dellacherie, Édith

doi:10.1002/macp.1983.021840204

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…The pharmacon was slowly released only in the presence of a-chymotripsin. [42] Quinidine was linked to carboxymethylcellulose via an amide bond using L-phenylalanine spacer to form a polymeric prodrug, controlling and programming the release. [43] p-Toluenesulfonylcelluloses (tosylcellulose) with different degrees of substitution (DS) ranging from 0.5 to 2.0 were reacted with various acid anhydrides including acetic, propionic and even fatty acid anhydrides to give acylated cellulose.…”

Section: Polymer Reactions and Propertiesmentioning

confidence: 99%

“…A similar approach used cellulose as a carrier for pholcodine, an antitussive drug, which was linked covalently to cellulose using L ‐phenylalanine as a spacer. The pharmacon was slowly released only in the presence of α ‐chymotripsin 42. Quinidine was linked to carboxymethylcellulose via an amide bond using L ‐phenylalanine spacer to form a polymeric pro‐drug, controlling and programming the release 43…”

Section: Polysaccharidesmentioning

confidence: 99%

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Biomacromolecules and Bio‐Related Macromolecules

Kobayashi

Uyama

2003

Macro Chemistry & Physics

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The present article briefly reviews research developments in the area of biomacromolecules and bio‐related macromolecules, whose research papers have been published for several decades preferably in the Macromolecular Journals. The area covers the important classes of macromolecules, polysaccharides (cellulose, amylose, chitin, etc.), polyesters (poly(lactic acid), poly(hydroxyalkanoate)s, etc.), and phenolic polymers (lignin, urushi, etc.). These polymers and their derivatives are very important for scientific interests as well as for industrial applications. Their synthesis, structure, reactions, and properties are mainly mentioned, and important topics of the target polymers are selected and mostly chronologically reviewed.

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Section: Polymer Reactions and Propertiesmentioning

confidence: 99%

Section: Polysaccharidesmentioning

confidence: 99%

Biomacromolecules and Bio‐Related Macromolecules

Kobayashi

Uyama

2003

Macro Chemistry & Physics

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“…7). mitting the determination of the corresponding values of K. It must be mentioned that the hydrolysis reaction represented by equilibrium (3) and the diffusion of soluble products were supposedly so fast that the adsorption (1) and the conformational arrangement between enzyme and substrate (2) were rate-determining steps.…”

Section: (13)mentioning

confidence: 99%

Specific‐enzyme release of cellulose‐bound drugs, experimental and theoretical study

Lapicque¹,

Dellacherie²

1986

J of Applied Polymer Sci

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SynopsisVarious polymeric prodrugs of pholcodine were prepared by covalently linking a substrate ester of the hydroxylic drug to cellulosic derivatives. "he ester derivatives of the drug were chosen so that the resulting insoluble cellulosic prodrugs became substrates of achymotrypsin. The hydrolysis of such compounds was studied for various spacer arms in conditions simulating the intestinal medium. A theoretical model was developed to describe the enzymatic catalysis of this hydrolysis, taking into account the adsorption of the enzyme onto the polymer, the hydrolysis reaction, and the enzyme denaturation. The resulting equations using independent ly determined parameter values such as the Langmuir adsorption constants, the enzyme denaturation constants, and the initial hydrolysis rate constant successfully correlated with the experimental data.

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Chitin/chitosan transformation by thermo‐mechano‐chemical treatment including characterization by enzymatic depolymerization

Pelletier

Lemire

Sygusch

et al. 1990

Biotech & Bioengineering

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Chitosan, the deacetylated derivative of chitin, was until recently produced by hydrolysis in 50% (w/v) NaOH. Application of thermo-mechano-chemical technology to chitin deacetylation was evaluated as an alternative method of chitosan production. This process consists of a cascade reactor unit operating under reduced alkaline conditions of 10% (w/v) NaOH. Prior mercerization of chitin at 4 degrees C for 24 h was required for high deacetylation yields. Sudden decompression of the aqueous alkaline suspension of mercerized chitin resulted in near complete deacetylation of chitin. Reactor residence time was 90 s at 230 degrees C prior to decompression. The chitosan produced was characterized by elemental analysis, (13)C-NMR and enzymatic depolymerization. Enzymatic determination of the degree of acetylation of chitin/chitosan mixtures was also investigated. Relative chitinase and/or chitosanase digestibilities were shown to be strongly dependent on chitin deacetylation. Based on enzymatic digestibilities, the alkaline aqueous high shear process does not appear to produce significant secondary products. Correlation of chitosanase digestibility with percentage of deacetylation provides a simple biological assay to study chitosan composition.

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Fixation sur cellulose de médicaments libérables par voie enzymatique

Cited by 7 publications

References 9 publications

Biomacromolecules and Bio‐Related Macromolecules

Biomacromolecules and Bio‐Related Macromolecules

Specific‐enzyme release of cellulose‐bound drugs, experimental and theoretical study

Chitin/chitosan transformation by thermo‐mechano‐chemical treatment including characterization by enzymatic depolymerization

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