Background: There is still a lack of consensus on which internal fixation method can better maintain the stability of femoral neck fractures (FNF), promote fracture healing, and avoid and reduce postoperative complications such as femoral head necrosis and nonunion. Therefore, the purpose of this study was to evaluate the clinical efficacy of the novel dynamic compression locking system (DCLS) versus dynamic hip screw (DHS) in the treatment of FNF.Methods: Fifty cases of FNF admitted from July 2018 to December 2020 were retrospectively analyzed. According to different treatment methods, they were divided into DCLS group (26 cases) and DHS group (24 cases). Baseline data, intraoperative and postoperative clinical data, complications, and Harris score were collected to evaluate the clinical efficacy. Results: All patients were followed up for 24 months, all of which were caused by falls. The baseline data of the two groups were comparable (P>0.05). There were not significant differences in the length of hospital stay and mobility between the two groups (P>0.05). The operation time, blood loss, incision length, fluoroscopy times and the degree of femoral neck shortening in the DCLS group were significantly less than those in the DHS group (all P<0.05). Harris score in the DCLS group was significantly higher than that in the DHS group (P<0.05). Complications of femoral head necrosis and nonunion in the DHS group were slightly higher than those in the DCLS group, but there was not statistical significance (P>0.05). Conclusion: DCLS is superior to DHS in the treatment of FNF, with advantages of less surgical trauma, simplified surgical procedures, lower radiation exposure dose for patients, good stability of internal fixation and better control of femoral neck shortening. However, there is not significant difference in fracture healing complications, which requires further study.