Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

Shimizu, Risa; Tsushima, Fumihiko; Komiya, Ruri; Yamagata, Yuko; Harada, Hiroyuki

doi:10.1159/000520534

Cited by 1 publication

(1 citation statement)

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“…Fixed drug eruption (FDE) is a common CADR characterized by well‐demarcated erythematous patches or plaques that may present with overlying blistering. Medications associated with FDE are NSAIDs, paracetamol, antihistamines and antimicrobials 80 . Recreational use of codeine in adolescents is a well‐documented cause of FDE 56 .…”

Section: Classification Of Cadrsmentioning

confidence: 99%

Drugs and the skin: A concise review of cutaneous adverse drug reactions

Pozzo‐Magaña

Liy‐Wong

2022

Brit J Clinical Pharma

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Drug‐induced skin disease or cutaneous adverse drug reactions (CADRs) are terms that encompass the clinical manifestations of the skin, mucosae and adnexa induced by a drug or its metabolites. The skin is the organ most frequently affected by drug reactions, which may affect up to 10% of hospitalized patients and occur in 1–3% of multimedicated patients. Most CADRs are mild or self‐resolving conditions; however, 2–6.7% of could develop into potentially life‐threatening conditions. CADRs represent a heterogeneous field and can be diagnostically challenging as they may potentially mimic any dermatosis. Currently, there are between 29–35 different cutaneous drug‐reaction patterns reported ranging from mild dermatitis to an extensively burnt patient. The most frequently reported are maculopapular rash, urticaria/angioedema, fixed drug eruption and erythema multiforme. Less common but more severe patterns include erythroderma, drug reaction with eosinophilia and systemic symptoms, and Stevens–Johnson syndrome/toxic epidermal necrolysis spectrum. Almost any drug can induce a CADR, but antibiotics, nonsteroidal anti‐inflammatory drugs and antiepileptics are the most frequently involved. Different mechanisms are involved in the pathogenesis of CADRs, although in some cases, these remain still unknown. CADRs could be classified in different ways: (i) type A (augmented) or type B (bizarre); (ii) immediate or delayed; (iii) immune‐mediated or nonimmune‐mediated; (iv) nonsevere or life‐threatening; and (v) by their phenotype, including exanthematous, urticarial, pustular and blistering morphology. Recognizing a specific CADR will mostly depend on the ability of the physician to perform a detailed clinical examination, the proper description of the morphology of the skin lesions and supporting laboratory and/or skin biopsy findings.

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Section: Classification Of Cadrsmentioning

confidence: 99%