Fixed drug eruption induced by topical olopatadine ophthalmic solution

Abstract

Fixed drug eruption (FDE) usually develops after oral administration and is described as a cutaneous reaction recurring at the same location each time the drug is taken. Olopatadine is both a H1 histamine receptor antagonist and a mast cell stabilizer, indicated for the treatment of allergic conjunctivitis. Here, we report a 14-year-old male patient who developed FDE localised on the lateral side of periorbital rim bilaterally, whilst applying olopatadine 0.1% ophthalmic solution for the treatment of allergic conjunctivitis. As far as we know, FDE due to olopatadine has not been previously reported in the literature. We deem it appropriate to report this case because FDE that results from the application of topical drugs is a rare event in the literature.

Multiple widespread fixed drug eruption caused by in a transdermal therapeutic system

“…FDE is typically associated with the consumption of oral medication. To date, there have been few reported cases associated with topical agents: plaster with Chinese herbs, 6 intravaginal metronidazole ovules, 7 analgesic plaster containing piroxicam, 8 olopatadine ophthalmic solution 9 and phenobarbital‐containing suppositories 10 . This demonstrates that FDE can appear after exposure to topical medications but high individual sensitivity is probably necessary.…”

Generalised bullous fixed drug eruption induced by a topical plaster with Chinese herbs

“…Generalised FDE in a 56‐year‐old Korean man was caused by an analgesic plaster containing piroxicam, whereas intravaginal metronidazole ovules induced GBFDE in a 35‐year‐old Argentine woman 3,4 . A 14‐year‐old Turkish male patient presented with FDE localised on the lateral side of his periorbital rims after applying olopatadine 0.1% ophthalmic solution 5 . In addition, two Turkish children were presented with FDE after application of phenobarbital‐containing suppositories 6 …”

“…3,4 A 14-year-old Turkish male patient presented with FDE localised on the lateral side of his periorbital rims after applying olopatadine 0.1% ophthalmic solution. 5 In addition, two Turkish children were presented with FDE after application of phenobarbital-containing suppositories. 6 The pathomechanism of FDE has been extensively studied.…”

Dermatological reactions to ophthalmic preparations: More than meets the eye

“…He also avoided using the Visine eye‐drops and had no further recurrences on follow up. Bilgili and colleagues reported a case of a 14‐year‐old boy who developed erythema localised bilaterally to the lateral periorbital rim . This occurred following use of 0.1% olopatadine (anti‐histamine) eye‐drops to treat allergic conjunctivitis.…”