Fixed drug eruption to cetirizine with positive lesional patch tests to the three piperazine derivatives

Cravo, Mariana; Gonçalo, Margarida; Figueiredo, Américo

doi:10.1111/j.1365-4632.2007.03131.x

Cited by 49 publications

(40 citation statements)

References 12 publications

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“…Nadiren lezyonlar çok say›da eritemli viyole yamalar ve büyük büller ile karakterize olan generalize büllöz fiks ilaç erüpsiyonuna dönüflür 2 . Sülfonamidler, tetrasiklinler, penisilinler, barbütiratlar, pirazolonlar, aspirin, oral kontraseptifler ve nonsteroid antiinflamatuvar ilaçlar baflta olmak üzere 100'den fazla ilaçla iliflkili fiks ilaç erüpsiyonu bildirilmifltir 3 . Bu olgu sunumunda, alerjik rinit tan›s› ile takip edilen bir hastada deri yama testi ile do¤rulanm›fl piperazin grubu antihistaminiklere karfl› fiks ilaç erüpsiyonu sunulmaktad›r.…”

Section: Giriflunclassified

Generalized Bullous Fixed Drug Eruption Associated with Cetirizine and Hydroxyzine Demonstrated by Patch Test

Arslan¹,

Taşlı²,

Kaçar³

et al. 2011

TURKDERM

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ÖzetFiks ilaç erüpsiyonu, neden olan ilaçlar›n tekrar eden al›mlar› sonucunda ayn› bölgelerde, genellikle soliter eritematöz parlak ya da koyu k›rm›z› makül, ödematöz plak ya da büllöz lezyonlar ile karakterizedir. Yüzden fazla ilaç suçlanmakla birlikte özellikle tetrasiklinler, sülfonamidler, sulfonlar, penisilinler, barbütiratlar, fenolfitolein, pirazolonlar, aspirin, oral kontraseptifler ve nonsteroid antiinflamatuvar ilaçlar sorumlu tutulmaktad›r. Alerjik rinit, ekzema, ast›m, ürtiker gibi pek çok hastal›¤›n tedavisinde yayg›n flekilde kullan›lan setirizin, hidroksizin, loratadin, levosetrizin gibi antihistaminiklere karfl› da fiks ilaç erüpsiyon geliflimi bildirilmifltir. Sorumlu ajan›n ortaya ç›kar›lmas›nda deri yama testi, intradermal testler, deri prick testi ya da oral uyar› testleri kullan›labilmektedir. K›rk üç yafl›nda erkek hasta alerjik rinit nedeniyle setirizin al›m›ndan yar›m saat sonras›nda ayak s›rtlar›ndan bafllayarak tüm vücuda da¤›lan kafl›nt›l› yer yer su kabarc›klar› içeren k›zar›kl›klar ile baflvurdu. Döküntüleri bafllad›ktan sonra hidroksizin kullan›m›yla lezyonlar›nda art›fl oldu¤unu belirten hastan›n öyküsünde 1 y›l önce de setirizin al›m›ndan sonra benzer yak›nmalar›n›n daha hafif bir flekilde oldu¤u ö¤renildi. Deri bak›s›nda vücutta yayg›n eritemli, keskin s›n›rl›, yer yer büllöz makül ve plaklar gözlendi. Lezyonlar›n gerilemesinden dört ay sonra sekiz farkl› antihistaminikle yap›lan deri yama testinde setirizin, levosetirizin ve hidroksizine karfl› pozitiflik saptand›. (Türkderm 2011; 45: 49-52) Anahtar Kelimeler: Fiks ilaç erüpsiyonu, setirizin, levosetirizin, hidroksizin SummaryFixed drug eruption (FDE) is characterized by solitary erythematous macules, edematous plaques and bullous lesions that occur at the same place with recurrent exposure to a drug. Though more than 100 drugs have been implicated in leading to FDE, this side effect is more commonly caused by tetracyclines, sulfonamides, sulfone, penicillins, pyrazolones, barbiturates, phenolphthalein, pirazones, aspirin, oral contraceptives and nonsteroidal anti-inflammatory drugs. FDE occurrence has been reported in association with cetrizine, hydroxyzine, loratadine and levocetirizine, which are widely used in the treatment of allergic diseases, such as allergic rhinitis, eczema, asthma, urticaria. Patch, intradermal skin, prick tests or oral challenge test can be performed to identify the agent responsible for FDE. A 43-year-old male patient attended our outpatient clinic with itchy and erythematous rashes with sporadic blisters, starting from dorsum of his feet and spreading to other parts of his body, following oral intake of cetirizine for allergic rhinitis. He described that his eruptions exacerbated with hydoxyzin. Patient's history revealed that he had slightly suffered from the same cutaneous reactions one year ago, after oral administration of cetirizine. On physical examination, multiple, round, erythematoviolaceous, well-defined macules and plaques, with central blisters localized on the trunk, arms and legs wer...

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Section: Giriflunclassified

Generalized Bullous Fixed Drug Eruption Associated with Cetirizine and Hydroxyzine Demonstrated by Patch Test

Arslan¹,

Taşlı²,

Kaçar³

et al. 2011

TURKDERM

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“…2,3 There are drugs responsible for hypersensitivity reaction including angioedema with or without urticaria. 4 Some of the cases are reported on skin reaction due to cetirizine and other antihistamines [5][6][7][8][9] but not a single case on cetirizine induced angioedema neither reported nor documented anywhere. Here, we present the first case of isolated bilateral angioedema of eye with a single oral dose of cetirizine.…”

Section: Introductionmentioning

confidence: 99%

Bilateral angioedema of eye with single dose of cetirizine

Majhee

Khan

Gari

2015

Int J Basic Clin Pharmacol

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“…This is the first report of fixed drug eruption to cetirizine with positive patch testing for hydroxyzine, cetirizine and levocetirizine (69).…”

mentioning

confidence: 99%

Treatment of Chronic Urticaria

Tončić

Lipozenčić²,

Marinović³

2009

Urticaria and Angioedema, Second Edition

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Summary Urticaria is a disorder characterized by rapid onset of localized swelling of the skin or mucosa, called wheals or urtica. According to frequency and duration, urticaria can be divided into acute and chronic type. Chronic urticaria is any type of urticaria occurring every day or twice per week, lasting longer than 6 weeks. Chronic urticaria is a common disorder and estimated prevalence is 1% of the population. Also, it is not rare in childhood. The pathogenesis of chronic urticaria has not yet been completely understood. Chronic urticaria is a heterogeneous group of disorders, and according to the etiology and cause, several groups of chronic urticaria are distinguished, i.e. autoimmune, pseudoallergic, infection-related, physical urticaria, vasculitis urticaria and idiopathic urticaria. Treatment and management of chronic urticaria can be non-pharmacological and pharmacological, and sometimes it is not possible to control the disease with antihistamines only, which are considered to be the mainstay of treatment. In severe cases of chronic urticaria, especially if autoimmunity has been proven, several authors describe different modules of immunomodulation: cyclosporine, cyclophosphamide, mycophenolate-mofetil, omalizumab, plasmapheresis, systemic corticosteroids, and immunoglobulin therapy. This article primarily addresses the treatment of chronic idiopathic and autoimmune urticaria.

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Fixed drug eruption to cetirizine with positive lesional patch tests to the three piperazine derivatives

Cited by 49 publications

References 12 publications

Generalized Bullous Fixed Drug Eruption Associated with Cetirizine and Hydroxyzine Demonstrated by Patch Test

Generalized Bullous Fixed Drug Eruption Associated with Cetirizine and Hydroxyzine Demonstrated by Patch Test

Bilateral angioedema of eye with single dose of cetirizine

Treatment of Chronic Urticaria

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