Fixed drug eruption to fluconazole: A case report and review of literature

Abstract

Fixed drug eruption (FDE) is mainly characterized by skin lesions that recur at the same anatomic sites upon repeated exposures to an offending agent. It represents the most common cutaneous adverse drug reaction pattern in Indian patients. Here, we report an FDE to fluconazole.

Retrospective analysis of fixed drug eruptions among patients attending a tertiary care center in Southern India

“…All relevant information was obtained from patients' OPD notes. All patients with a history of drug intake followed by classical FDE lesions and those who had a definite or probable adverse drug reaction according to the Naranjo probability score [2] were included in this study.…”

“…Complete blood counts Our case series also provided some interesting findings such as two cases of recurrent FDE to fluconazole, one of which we have already reported. [2] The high proportion of patients with recurrent episodes (58%) may be attributed to polypharmacy, the low rate of recognition of FDE in general practice or the attitude of patients.…”

“…[2] With the increasing use of fluoroquinolones, ciprofloxacin has now overtaken other drugs in more recent studies of FDE. [5] In our study, fluoroquinolones, and in particular the ofloxacin-ornidazole fixed dose combination was responsible for the greatest number of cases of FDE.…”

Doxycycline induced generalized bullous fixed drug eruption – A case report

“…Predisposing genetic background probably reflects this adverse drug reaction. 3 It is characterized by pruritic, well-circumscribed, erythematous patches at the same site with reexposure to an offending drug. Subsequent exposure may increase the number of sites.…”

“…More T cells and neutrophils are recruited to the FDE site causing tissue damage. 3 The commonly used drugs causing FDE are antibiotics such as trimethoprim-sulfamethoxazole, penicillin, tetracycline and erythromycin followed by non-steroidal anti-inflammatory drugs (NSAIDS) like diclofenac sodium, aspirin, ibuprofen and naproxen and also some of the antiepileptics. 5 In this case, patient developed adverse reaction within one day following administration of doxycycline.…”