Fixed Drug Eruption to Ingested Propolis

Ramien, Michele; Pratt, Melanie D.

doi:10.1097/der.0b013e318262cac2

Cited by 13 publications

(7 citation statements)

References 21 publications

(9 reference statements)

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“…FDEs are almost always associated with new medication. However, a small body of literature describes FDE with confirmed non-medication sources [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. These sources are either food or chemical additives found in food, leading to the proposition of the term ‘fixed food eruption’ to describe this subset of localized hypersensitivity reaction [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Fixed Drug Eruption due to Achiote Dye

Tattersall

Reddy²

2016

Case Rep Dermatol

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Fixed drug eruption (FDE) is a localized type IV sensitivity reaction to a systemically introduced allergen. It usually occurs as a result of new medication, making identification and avoidance of the trigger medication straightforward; however, in a rare subset of cases no pharmacological source is identified. In such cases, the causative agent is often a food or food additive. In this report we describe a case of a FDE in a 12-year-old girl recently immigrated to the United States from Ecuador who had no medication exposure over the course of her illness. Through an exhaustive patient history and literature review, we were able to hypothesize that her presentation was caused by a dietary change of the natural achiote dye used in the preparation of yellow rice to a locally available commercial dye mix containing tartrazine, or Yellow 5, which has previously been implicated in both systemic hypersensitivity reactions and specifically in FDE. This report adds to the small body of available literature on non-pharmacological fixed hypersensitivity eruptions and illustrates an effective approach to the management of such a presentation when history is not immediately revealing.

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Section: Discussionmentioning

confidence: 99%

Fixed Drug Eruption due to Achiote Dye

Tattersall

Reddy²

2016

Case Rep Dermatol

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“…107,120Y127 Oral administration of honey or propolis-containing products (capsules, tablet, powders, sprays) by patients allergic to propolis may cause generalized skin eruptions, 128,129 fixed drug eruption, 130 and erythroderma. 107,120Y127 Oral administration of honey or propolis-containing products (capsules, tablet, powders, sprays) by patients allergic to propolis may cause generalized skin eruptions, 128,129 fixed drug eruption, 130 and erythroderma.…”

Section: Contact Allergy and Allergic Contact Dermatitismentioning

confidence: 99%

Propolis

Groot¹

2013

Dermatitis

179

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Propolis (bee glue) is the resinous substance that bees collect from living plants for the construction and adaptation of their nests. It has antibacterial, antifungal, and antiviral properties and may have a wide range of other beneficial biological activities. Propolis is available as a dietary supplement, in products for the protection of health and prevention of diseases, in biopharmaceuticals, and as a constituent of (bio)cosmetics. In this article, the following aspects of propolis are reviewed: the nature and chemical composition, its biological properties and applications, contact allergy and allergic contact dermatitis (sensitizing potential, products causing contact allergy, clinical picture, frequency of sensitization, coreactivity and cross-reactivity, the allergens in propolis), and other adverse effects.

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“…In addition to allergic contact dermatitis, there are also reported cases of systemic reactions or fixed drug eruptions after propolis ingestion. To our knowledge, a case of propolis‐induced erythema multiforme‐like contact dermatitis has hitherto not been described.…”

Section: Discussionmentioning

confidence: 99%