To intercept the maneuvering target through multimissile cooperation, predefined-time cooperative guidance (PTCG) law is presented with constraints including the impact time and the line-of-sight (LOS) angle. In order to achieve simultaneous interception, we propose a PTCG law in the LOS direction based on a predefined-time consensus protocol, which guarantees the achievement of consensus on each missile’s impact time within the predefined time. Furthermore, to ensure the predefined-time convergence of the LOS angle and the predefined-time convergence of the LOS angular rate, a PTCG law with a fixed-time disturbance observer (FxTDO) is presented in the normal direction of the LOS. Compared with the traditional finite-time or fixed-time cooperative guidance laws, the proposed PTCG law predefines the upper bound of the settling time as an explicit parameter. Finally, the simulation results of the PTCG law verify the efficiency of the proposed method.