Fixel-based Analysis of Diffusion MRI: Methods, Applications, Challenges and Opportunities

Dhollander, Thijs; Clemente, Adam; Singh, Mervyn; Boonstra, Frederique; Civier, Oren; Duque, Juan Dominguez; Egorova, Natalia; Enticott, Peter G.; Fuelscher, Ian; Gajamange, Sanuji; Genc, Sila; Gottlieb, Elie; Hyde, Christian; Imms, Phoebe; Kelly, Claire E.; Kirkovski, Melissa; Kolbe, Scott; Liang, Xiaoyun; Malhotra, Atul; Mito, Remika; Poudel, Govinda; Silk, Tim; Vaughan, David N.; Zanin, Julien; Raffelt, David; Caeyenberghs, Karen

doi:10.1016/j.neuroimage.2021.118417

Cited by 174 publications

(219 citation statements)

References 111 publications

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“…This is the first application of a fixel-based analysis in preHD. Fixel-based analysis offers an improvement over previously studied DTI methods by accounting for crossing fibre populations to provide more reliable tractograms and account for the differing ways in which changes to intra-axonal volume may occur by quantifying both a measure of fibre density and a measure of fibre bundle cross section ( Raffelt et al, 2017 , Dhollander et al, 2021 ). Two studies have previously studied fixel-based analysis in manifest HD cohorts ( Adanyeguh et al, 2021 , Oh et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Timing of selective basal ganglia white matter loss in premanifest Huntington’s disease

Zeun

McColgan

Dhollander

et al. 2022

NeuroImage: Clinical

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Highlights Limbic and caudal motor cortico-striatal tracts appear to be selectively vulnerable to degeneration in the early premanifest Huntington’s disease (preHD), approximately 11 years from predicted onset. Similarly of cortico-thalamic connections, pre-motor and primary motor-thalamic connections appear selectively vulnerable to early degeneration. However these connections appear preserved in a preHD cohort 25 years from predicted onset. This highlights vulnerable subregions of the striatum and thalamus that may be important targets for future therapies that seek to prevent early neurodegeneration in preHD.

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Section: Discussionmentioning

confidence: 99%

Timing of selective basal ganglia white matter loss in premanifest Huntington’s disease

Zeun

McColgan

Dhollander

et al. 2022

NeuroImage: Clinical

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“…Comparatively, FC is a measure of white matter macrostructure and can be used to determine changes within the cross-sectional distribution of axons within a fiber bundle. 23 …”

Section: Methodsmentioning

confidence: 99%

Auditory Dysfunction Among Individuals With Neurofibromatosis Type 1

et al. 2021

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Key Points Question Is neurofibromatosis type 1 (NF1) associated with auditory neural dysfunction and functional hearing consequences? Findings In this case-control study of 44 individuals with NF1 and 44 matched control participants, 1 in 4 participants with NF1 showed evidence of auditory neural dysfunction, and 1 in 3 presented with abnormal functional hearing (speech perception). Diffusion-weighted magnetic resonance imaging analysis showed that participants with NF1 had significantly lower apparent fiber density within the ascending tracts of the brainstem. Meaning The findings of this study suggest that auditory dysfunction severe enough to impede developmental progress in children and restrict communication in older participants is a common neurobiological feature of NF1.

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“…The FOD can be segmented into discrete elements based on peaks, or lobes, that are considered to be representative of a specific orientation of a set of axons within each voxel. These fiber elements are referred to as fixels (Dhollander et al, 2021;D. A. Raffelt et al, 2017), and are parameterized by the mean orientation of fibers within the lobe of the FOD.…”

Section: Nomenclaturementioning

confidence: 99%

“…Thus, there can be multiple fixels in a single voxel, with the advantage that we can now assign a specific property or index to each fixel, or orientation, within a voxel. It is important to note that segmentation of a continuous FOD is just one way in which fixels can be obtained, and there are several descriptions of axon directionality that can be used to characterize fixels within voxels (Dhollander et al, 2021).…”

Section: Nomenclaturementioning

confidence: 99%

Prevalence of white matter pathways coming into a single white matter voxel orientation: The bottleneck issue in tractography

Schilling

Tax

Rheault

et al. 2021

Human Brain Mapping

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Characterizing and understanding the limitations of diffusion MRI fiber tractography is a prerequisite for methodological advances and innovations which will allow these techniques to accurately map the connections of the human brain. The so-called "crossing fiber problem" has received tremendous attention and has continuously triggered the community to develop novel approaches for disentangling distinctly oriented fiber populations. Perhaps an even greater challenge occurs when multiple

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Fixel-based Analysis of Diffusion MRI: Methods, Applications, Challenges and Opportunities

Cited by 174 publications

References 111 publications

Timing of selective basal ganglia white matter loss in premanifest Huntington’s disease

Timing of selective basal ganglia white matter loss in premanifest Huntington’s disease

Auditory Dysfunction Among Individuals With Neurofibromatosis Type 1

Prevalence of white matter pathways coming into a single white matter voxel orientation: The bottleneck issue in tractography

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