Flagellar length control in monoflagellates by motorized transport: Growth kinetics and correlations of length fluctuations

Flagellar length fluctuations: quantitative dependence on length control mechanism

“…An alternative supply of large quantities tubulins, adequate for positive correlation, may come from translational bursting. The length fluctuations of the pair of daughter flagella undergoing ciliogenesis prior to cell division in the monoflagellates, are also positively correlated [6].…”

“…(i) Anticorrelated: During the regeneration of a selectively amputated flagellum [5] or the replication of a daughter flagellum [6], the pool can get get severely depleted. The negative correlation observed [4] indicates that, in such situations, one flagellum can elongate only if the other shortens simultaneously because the limited resources in the shared pool of precursors is inadequate to support sustained growth of a flagellum (Fig.…”

“…Here we summarize the key questions and the fundamental importance of the recent developments. Although our attention is focussed here mainly on the experimental [2] and theoretical [2][3][4][5][6][7] works on eukaryotic flagellum, the ideas are general and applicable to wide varieties of cell organelle.…”

Flagellar length control in multiflagellated eukaryotes: a case study with Giardia

“…In this section we summarize the general modeling strategy that we have developed recently for flagellar length control and applied to monoflagellates [23] and biflagellates [25]. In this approach, a flagellum is represented as a pair of antiparallel lattices, where each lattice represents a MT of the doublet.…”

“…Fourth, in case of multiflagellates or monoflagellates which become transiently multiflagellated [23], the multiple flagella coordinate their growing and shortening dynamics. So, the fourth question is: how do the two flagella communicate with each other through a common shared pool of resources like structural proteins and transport vehicles [24,25]?…”