FLAIR with Contrast Linked to Better Correlation with Stroke Symptoms than Diffision-Weighted Imaging in a Patient: Detecting Hyperintense Acute Reperfusion Injury Marker and Cortical Enhancement

Karageorgiou, Elissaios; Schwab, Daniel; Ezzeddine, Mustapha A.

doi:10.1159/000342759

Cited by 2 publications

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“…This finding may be attributable to other causes or TIA rather than acute lacunar infarction itself. Recent studies have shown that TIA and imaging-negative strokes might be HARM positive and associated with focal BBB disruption ( 40 , 42 ). Lee et al ( 43 ) suggested that a finding of HARM without diffusion abnormalities represents a specific type of TIA with favorable short-term neurologic outcomes, compared with imaging-negative stroke.…”

Section: Discussionmentioning

confidence: 99%

Role of Hyperintense Acute Reperfusion Marker for Classifying the Stroke Etiology

et al. 2017

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PurposeThe hyperintense acute reperfusion marker (HARM) is a delayed enhancement of the subarachnoid or subpial space observed on post-contrast fluid-attenuated inversion recovery (FLAIR) images and is associated with permeability changes to the blood–brain barrier in acute stroke. We investigated the relationship between HARM and stroke etiology based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification. In addition, we evaluated the relationship between HARM and stroke locations with respect to vascular territories and anatomic compartments.Materials and methodsWe recruited 264 consecutive patients (109 women; mean age 68.63 years) who were diagnosed with acute ischemic stroke and underwent brain magnetic resonance imaging (MRI) including post-contrast FLAIR and DWI within 7 days of symptom onset from May 2015 to March 2016 for this retrospective study. Post-contrast FLAIR images were obtained 5 min after gadolinium administration. The mean time interval between the onset of stroke symptoms and MRI acquisition in total included patients was 18 h and 7 min (median 12 h and 57 min, range 2–127 h). We analyzed the overall incidence and distribution patterns of HARM in acute ischemic stroke cases and compared the relative incidence and distribution patterns of HARM between the subgroups of stroke etiology based on conventional TOAST classification. We obtained odds ratio (OR) of HARM in different stroke locations based on vascular territories and anatomical compartments. This study was approved by our institutional review board.ResultsAmong the 264 patients, 67 (25.38%) patients were HARM positive and 197 (74.62%) patients were HARM negative. There was significant difference in HARM incidence among the stroke subgroups (p < 0.001). Small vessel occlusion (SVO) was associated with the HARM-negative group (p < 0.001), while large artery atherosclerosis (LAA) and cardioembolism (CE) were associated with the HARM-positive group (p = 0.001). Also, regional pattern of HARM on the same vascular territory as the acute infarction was dominantly demonstrated regardless of stroke etiology. The OR for HARM from middle cerebral artery (MCA) infarction was 1.868 [95% confidence interval (CI): 1.025–3.401]. The OR for HARM from cortical infarction was 9.475 (95% CI: 4.754–18.883) compared to other anatomic compartments.ConclusionThe presence of the HARM was significantly associated with embolic infarctions including LAA and CE. Conversely, SVO was exclusively associated with the absence of the HARM. Second, MCA and cortical infarction showed a more pronounced HARM compared to infarctions at other vascular territories and anatomic compartments. According to the results in the current study, we speculate that the presence of HARM on post-contrast FLAIR images was associated with specific stroke causes especially in embolic causes.

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Section: Discussionmentioning

confidence: 99%

Role of Hyperintense Acute Reperfusion Marker for Classifying the Stroke Etiology

et al. 2017

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Neglect and extinction in kinesthesia and thesesthesia: understanding proprioceptive inattention

Karageorgiou

2015

Neurocase

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This paper describes a new observation of neglect and extinction of kinesthesia and thesesthesia (movement and position imperception), jointly reflecting proprioceptive inattention, in a series of patients with parietal lesions. A prototypical case is discussed in detail and unaddressed aspects of proprioceptive inattention are discussed through findings from four additional cases. Thesesthetic and kinesthetic extinction were tested through simultaneous antidromic vertical displacement of index fingers, while having patients report on finger proprioceptive perception with eyes closed. Patients had variable degrees of proprioceptive inattention affecting a specific limb, but without pallesthetic inattention or somatoagnosia, whereas symptoms often resolved with visual feedback or active limb movements. Findings support that kinesthesia and thesesthesia (a) are subserved by near-identical brain networks, (b) relate more to tactile perception than pallesthesia in higher order cortical areas, and (c) have a somatotopic cortical organization even in association brain areas. Furthermore, proprioceptive extinction and neglect involve (i) "attention network" structures, (ii) either hemisphere, (iii) gray or subcortical white matter damage, (iv) defective vigilance mechanisms possibly through premature habituation of spatiotemporally saturated neural capacitor circuits, and (v) are not the result of somatoagnosia, while (vi) their resolution is observed through reafferent motor-sensory or visual feedback.

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FLAIR with Contrast Linked to Better Correlation with Stroke Symptoms than Diffision-Weighted Imaging in a Patient: Detecting Hyperintense Acute Reperfusion Injury Marker and Cortical Enhancement

Cited by 2 publications

References 14 publications

Role of Hyperintense Acute Reperfusion Marker for Classifying the Stroke Etiology

Role of Hyperintense Acute Reperfusion Marker for Classifying the Stroke Etiology

Neglect and extinction in kinesthesia and thesesthesia: understanding proprioceptive inattention

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