The flat-spectrum radio quasar 3C 454.3 throughout the years has presented very high activity phases (flares) in which the different wavebands increase their flux dramatically. In this work, we perform multiwavelength analysis from radio to gamma-rays and study the Mg II λ2798 Å emission line and the UV Fe II band from 2008-2018. We found that an increase in the 43 GHz flux density of the quasi-stationary component C, coincides with the estimated time at which a superluminal blob ejected from the radio core (which caused the brightest flare of 2010) collides with the quasi-stationary component (at a projected distance of ∼ 4.6 pc from the radio core). The spectral index different behavior in the first (5000 < JD − 2450000 < 5600) and second (6600 < JD − 2450000 < 7900) flaring periods suggest changes in the physical conditions. The complex nature of the second period can be a result of a superposition of multiple events at different locations. The Mg II has an anti-correlation with the UV-continuum while Fe II correlates positively. Except by the time of the brightest flare of 2010, when both have a strong response at high continuum luminosities. Our results suggest that the dominant gamma-ray emission mechanism for the first flaring period is External Compton. For the second flaring period the seed photons emission region is co-spatial with the gamma-ray emission region. However, a SED study using a multizone jet emission model is required to confirm the nature of each significant flare during the second period.