Flash Photolysis in Aqueous Nitrite Solutions

Strehlow, H.; Wagner, I.

doi:10.1524/zpch.1982.132.2.151

Cited by 56 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, the reaction of ·NO • with LOO • species predominates over the slower initiation of secondary peroxidation propagation reactions by LOO • with vicinal unsaturated lipids (29,30). (6)(7)(8)(9). In accordance with the prevailing opinion, in aqueous solutions the N-O bond of the nitrite ion will be cracked by the energy of light at a wavelength of 340-360 nm.…”

Section: Discussionmentioning

confidence: 79%

“…This effect is markedly potentiated by solutions containing nitrite (4,5), indicating that under certain circumstances, nitrite may exhibit relaxing activities comparable to NO. Indeed, studies in environmental chemistry revealed that both the nitrite anion and nitrous acid (HNO 2 ) in aqueous solutions undergo photodecomposition when irradiated with UV light at 200-400 nm, resulting in the formation of NO (6)(7)(8)(9).…”

mentioning

confidence: 99%

See 1 more Smart Citation

The presence of nitrite during UVA irradiation protects from apoptosis

Suschek¹,

Schröeder

Aust

et al. 2003

FASEB j.

View full text Add to dashboard Cite

Nitrite occurs ubiquitously in biological fluids such as blood and sweat, representing an oxidation product of nitric oxide. Nitrite has been associated with a variety of adverse effects such as mutagenicity, carcinogenesis, and toxicity. In contrast, here we demonstrate that the presence of nitrite, but not nitrate, during irradiation of endothelial cells in culture exerts a potent and concentration-dependent protection against UVA-induced apoptotic cell death. Protection is half-maximal at a concentration of 3 mM, and complete rescue is observed at 10 mM. Nitrite-mediated protection is mediated via inhibition of lipid peroxidation in a similar manner as seen with butylated hydroxytoluene, a known inhibitor of lipid peroxidation. Interestingly, nitrite-mediated protection is completely abolished by coincubation with the NO scavenger cPTIO. Using electron paramagnetic resonance (EPR) spectroscopy or Faraday modulation spectroscopy, we directly prove UVA-induced NO formation in solutions containing nitrite. In conclusion, evidence is presented that nitrite represents a protective agent against UVA-induced apoptosis due to photodecomposition of nitrite and subsequent formation of NO.

show abstract

Section: Discussionmentioning

confidence: 79%

mentioning

confidence: 99%

The presence of nitrite during UVA irradiation protects from apoptosis

Suschek¹,

Schröeder

Aust

et al. 2003

FASEB j.

View full text Add to dashboard Cite

show abstract

“…However the production of NO 2 · via the oxidation of nitrosothiols by H 2 O 2 is likely to be in most cases a delayed reaction that would prevent any efficient recombination with the short-life tyrosyl radical. Alternatively, tyrosine could be nitrated directly by radicals generated by the decomposition of cellular NO 2 − 42, which is highly probable at conditions allowing water radiolysis, since the O-N-O bond energy (93.3 KJ mol −1 ≈ 0.93 eV) is approximately five time lower than that of O-H in water (450 KJ mol −1 ≈ 4.5 eV)434445. However, generation of 3-nitrotyrosine by this reaction would require that both tyrosyl and NO 2 · radicals are generated in a very close vicinity, which seems a rather unlikely event.…”

Section: Discussionmentioning

confidence: 99%

Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams

Raschke

Spickermann

Toncian

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Ultra-short proton pulses originating from laser-plasma accelerators can provide instantaneous dose rates at least 107-fold in excess of conventional, continuous proton beams. The impact of such extremely high proton dose rates on A549 human lung cancer cells was compared with conventionally accelerated protons and 90 keV X-rays. Between 0.2 and 2 Gy, the yield of DNA double strand breaks (foci of phosphorylated histone H2AX) was not significantly different between the two proton sources or proton irradiation and X-rays. Protein nitroxidation after 1 h judged by 3-nitrotyrosine generation was 2.5 and 5-fold higher in response to conventionally accelerated protons compared to laser-driven protons and X-rays, respectively. This difference was significant (p < 0.01) between 0.25 and 1 Gy. In conclusion, ultra-short proton pulses originating from laser-plasma accelerators have a similar DNA damaging potential as conventional proton beams, while inducing less immediate nitroxidative stress, which probably entails a distinct therapeutic potential.

show abstract

“…The OH-quantum yield in the photolysis of nitrite (Treinin and Hayon, 1970;Strehlow and Wagner, 1982) viz.…”

Section: No2 Photolysismentioning

confidence: 99%

Absolute OH quantum yields in the laser photolysis of nitrate, nitrite and dissolved H2O2 at 308 and 351 nm in the temperature range 278?353 K

1990

View full text Add to dashboard Cite

Absolute quantum yields for the formation of OH radicals in the laser photolysis of aqueous solutions of NO], NO2 and H202 at 308 and 351 nm and as a function ofpH and temperature have been measured. A scavenging technique involving the reaction between OH and SCN-ions and the time resolved detection by visible absorption of the (SCN)~ radical ion was used to determine the absolute OH yields. The following results were obtained:(1) NO] -photolysis: 308 nm: ~OH(298 K)=0.017 +_0.003 for 4~

show abstract

Flash Photolysis in Aqueous Nitrite Solutions

Cited by 56 publications

References 12 publications

The presence of nitrite during UVA irradiation protects from apoptosis

The presence of nitrite during UVA irradiation protects from apoptosis

Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams

Absolute OH quantum yields in the laser photolysis of nitrate, nitrite and dissolved H2O2 at 308 and 351 nm in the temperature range 278?353 K

Contact Info

Product

Resources

About