2024
DOI: 10.3390/ijms252312506
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FLASH Radiotherapy: Benefits, Mechanisms, and Obstacles to Its Clinical Application

Lina Alhaddad,
Andreyan N. Osipov,
Sergey Leonov

Abstract: Radiotherapy (RT) has been shown to be a cornerstone of both palliative and curative tumor care. RT has generally been reported to be sharply limited by ionizing radiation (IR)-induced toxicity, thereby constraining the control effect of RT on tumor growth. FLASH-RT is the delivery of ultra-high dose rate (UHDR) several orders of magnitude higher than what is presently used in conventional RT (CONV-RT). The FLASH-RT clinical trials have been designed to examine the UHDR deliverability, the effectiveness of tum… Show more

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