Flat and valgus deformation of feet in children: ways of treatment (literature review)

Ryzhov, Pavel V.; Викторович, Рыжов Павел; Pirogova, Nataliya V.; Владимировна, Пирогова Наталья; Bagdulina, Olga D.; Дмитриевна, Багдулина Ольга; Shmelkov, Andrey V.; Владимирович, Шмельков Андрей

doi:10.17816/2072-2354.2020.20.3.114-118

Cited by 1 publication

(1 citation statement)

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“…Children who are overweight or obese have an increased risk of developing type 2 diabetes and cardiovascular disease in adulthood. In addition, excess weight in children is associated with musculoskeletal problems, as well as valgus misalignment of the knees or flat feet (Ratu Alicia, 2023;Ryzhov et al, 2020). It can also affect balance, posture, and the ability to move efficiently, and may even increase the risk of osteoarthritis at an early age (Calcaterra et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

The relationship between body mass index and lower extremity biomechanics in children aged 10-12 years: a comprehensive analysis

Lahoz,

Pérez-Rey,

González

et al. 2024

EJA

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Adipose-derived mesenchymal stem cells are a great alternative to other types of stem cells obtained from other tissues since they are found in large numbers; they are easy to obtain by liposuction and do not have ethical connotations. These cells can differentiate into neuronal lineage using induction media, although the efficacy of these media is determined by their composition. In previous studies, we have demonstrated the differentiation of human adipose-derived mesenchymal stem cell to neuronal lineage by using three induction media Neu1, Neu2 and Neu3, each one showing a series of neuronal markers in the treated cells. In the present study, a further step is taken since once a neuronal differentiation is obtained with these three induction media, they are removed from the medium and both morphology and neuronal markers and the ability to maintain neurosphere formation are analysed. The results obtained show that when these induction media are withdrawn in the three cases, both the neuronal morphological characteristics and the neuronal markers are lost at different times depending on the medium used. In the case of neurospheres, the ability to maintain this shape is also lost when they are not in contact with neuronal induction factors. Therefore, although the neuronal differentiation mechanism is very promising in this type of cells, it is necessary to carry out more studies to elucidate an induction medium that allows cells differentiated into neurons to maintain neuronal characteristics over time without the need to continue applying neuronal differentiation factors.

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Section: Introductionmentioning

confidence: 99%