Flavan-3-ols and Flavonoids fromPotentilla anserina

Abstract

Roots/rhizomes and aerial parts of Potentilla anserina L. (Rosaceae) contain two flavan-3-ols: (+)-catechin and (+)-gallocatechin. The flavonol glycosides and glucuronides isolated from the herb were kaempferol 3- O-beta- D-glucoside, kaempferol 3- O-beta- D-(6''- O-( E)- P-coumaroyl)glucopyranoside, quercetin 3- O-beta- D-glucoside, quercetin 3- O-beta- D-xyloside, quercetin 3- O-alpha- L-rhamnoside, quercetin 3- O-beta- D-sambubioside, quercetin 3- O-beta- D-glucuronide, isorhamnetin 3- O-beta- D-glucuronide, myricetin 3- O-alpha- L-rhamnoside, and myricetin 3- O-beta- D-glucuronide. Herbacetin 8-methyl ether-3- O-beta- D-sophoroside (8-methoxykaempferol 3-sophoroside) was identified in the flowers. The 6''-methyl ester of quercetin 3- O-beta- D-galacturonide, which may be an artifact, was isolated from the herb. The total flavonoid content calculated as quercetin-3- O-beta- D-glucuronide was 1% in the lyophilized herb used in this study and 0.5% in a commercial drug, meeting DAC standards.

Potentilla—A review of its phytochemical and pharmacological profile

“…Potentilla anserina Kombal and Glasl (1995) Bate-Smith (1961) Krzaczek ( logical and histopathological studies confirmed the effectiveness of an orally administered extract of the leaves of this species for ethanol-induced peptic ulcers in rats (Gürbüz et al, 2005). Russian authors (Popov et al, 2006) obtained interesting results when testing the influence of comaruman, a pectin isolated from aerial parts of Comarum palustre (syn.…”

“…Potentilla anserina Kombal and Glasl (1995) Quercetin-3-O-␣-l-rhamnoside (quercitrin) Potentilla anserina; Potentilla fruticosa; Potentilla fragarioides Fedoseeva (1979) Kombal and Glasl (1995) Choi et al (1998) Quercetin-3-O-␣-l-arabinofuranoside Potentilla areata; Potentilla fruticosa d ; Potentilla discolor Klyshev and Pershukova (1989) Miliauskas et al (2004) Xue et al (2006) Quercetin-3-O-␣-l-arabinopyranoside Potentilla fruticosa Ganenko et al (1988) Quercetin-3 -glucoside Potentilla erecta; Potentilla reptans Harborne and Nash (1984) …”

“…Potentilla anserina Kombal and Glasl (1995) Quercetin Miliauskas et al (2004) Tomczyk (2006) Quercetin-3-O-␤-d-glucuronide Potentilla anserina; Potentilla fruticosa d Harborne and Nash (1984) Kombal and Glasl (1995) Miliauskas et al (2004) Quercetin-3,7-diglucuronide Potentilla reptans Harborne (1965) Harborne and Baxter (1999) …”

“…Condensed tannins (proanthocyanidins) and their precursors (+)-CatechinPotentilla erecta,Vennat et al (1992) Potentilla anserinaKombal and Glasl (1995) Potentilla albaGritsenko and Smik (1977) Potentilla viscosaZhang et al (1988) (+)-Catechin 3-O-glucoside Potentilla viscosa Zhang et al (1988) (−)-Epicatechin Potentilla erecta Vennat et al (1992) Potentilla alba Oszmiański et al (2007) (+)-Gallocatechin Potentilla erecta, Vennat et al (1992) Potentilla chrysantha TREV. Omurkamzinova and Erzhanova (1986) Potentilla anserina Kombal and Glasl (1995) (−)-Epigallocatechin Potentilla erecta Selenina et al (1973) (−)-Epigallocatechingallate Dimers [6 ,6]-All-trans-bi-(+)-catechin Potentilla erecta Ahn (1974) potentillanin Potentilla viscosa Zhang et al (1988) [4,8]-All-trans-bi-(+)-catechin (procyanidin B3) Potentilla erecta Schleep et al (1986) Potentilla viscosa Zhang et al (1988) [4,6]-All-trans-bi-(+)-catechin (procyanidin B6) Potentilla erecta Schleep et al (1986) [4,8]-All-trans-bi-(+)-catechin 3 -O-glucoside Potentilla viscosa Zhang et al (1988) [4,8]-2,3-trans-3,4-cis-bi-(+)-catechin Potentilla erecta Schleep et al (1986) Procyanidin B1 (traces) Potentilla erecta Vennat et al (1992) Procyanidin B2 (traces) Procyanidin B5 (traces) Trimers (+)-Catechin-[6 ,8]-(+)-catechin-[4,8]-(+)-catechin Potentilla erecta Ahn (1974) (+)-Catechin-[4,8]-(+)-catechin-[4,8]-(+)-catechin Afzelechin-[4,8]-all-trans-bi-(+)-catechin Potentilla viscosa Zhang et al (1988) • Triterpenoids Ursolic acid Potentilla anserina Li et al (2003) Pomolic acid 3-Epi-pomolic acid 28-O-␤-d-glucoside Potentilla erecta Bilia et al (1992) Tormentic acid Potentilla erecta Potier et al (1966) Potentilla anserina Li et al (2003) Arjunetin Potentilla erecta Stachurski et al (1995) Euscaphic acid Potentilla anserina Li et al (2003) Euscaphic acid 28-O-␤-d-glucoside (kaji-ichogoside F1) Potentilla erecta Stachurski et al (1995) Potentilla anserina Li et al (2003) Chinovic acid…”

Anti-inflammatory, antioxidant and anti-acetylcholinesterase activities of Bouvardia ternifolia: potential implications in Alzheimer’s disease

“…Regarding the BtFlav3 fraction, its principally content was the flavonol 3-O-quercetin rhamnopyranoside (4), following by 3-O-quercetin glucopyranoside (5), and rutin (6). In the case of compounds 4 and 5, the identification was achieved by comparison between the experimental data obtained by spectroscopic and spectrometric data of the isolated compounds and the literature (Kombal and Glasl 1995;Yen et al 2009). The identification of compound 6 was determined by HPLC analysis when experimental peak overlapped with the commercial standard, although the detection wavelength was scanned at 190-400 nm.…”