Flavanol Molluscicides from the Sudan Acacias

Ayoub, Saad Mohamed Hussein

doi:10.3109/13880208509069007

Cited by 17 publications

(4 citation statements)

References 5 publications

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“…From other species of Acacia, methanol extract from Acacia ampliceps bark showed significant to moderate inhibition against Trichoderma spp., Rhizopus and Acremonium spp. and less activity against Aspergillus niger [ 99 ]. Fruits and bark ethyl acetate extracts of A. nilotica (L.) Willd.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Phytoconstituents from Alcoholic Extracts of Four Woody Species and Their Potential Uses for Management of Six Fusarium oxysporum Isolates Identified from Some Plant Hosts

Salem

Mohamed²,

Ali

et al. 2021

Plants

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Background: Trees are good sources of bioactive compounds as antifungal and antioxidant activities. Methods: Management of six molecularly identified Fusarium oxysporum isolates (F. oxy 1, F. oxy 2, F. oxy 3, F. oxy 4, F. oxy 5 and F. oxy 6, under the accession numbers MW854648, MW854649, MW854650, MW854651, and MW854652, respectively) was assayed using four extracts from Conium maculatum leaves, Acacia saligna bark, Schinus terebinthifolius wood and Ficus eriobotryoides leaves. All the extracts were analyzed using HPLC-VWD for phenolic and flavonoid compounds and the antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and β-carotene-linoleic acid (BCB) bleaching assays. Results: In mg/kg extract, the highest amounts of polyphenolic compounds p-hydroxy benzoic, benzoic, gallic, and rosmarinic acids, with 444.37, 342.16, 311.32 and 117.87, respectively, were observed in C. maculatum leaf extract; gallic and benzoic acids with 2551.02, 1580.32, respectively, in A. saligna bark extract; quinol, naringenin, rutin, catechol, and benzoic acid with 2530.22, 1224.904, 798.29, 732.28, and 697.73, respectively, in S. terebinthifolius wood extract; and rutin, o-coumaric acid, p-hydroxy benzoic acid, resveratrol, and rosmarinic acid with 9168.03, 2016.93, 1009.20, 1156.99, and 574.907, respectively, in F. eriobotryoides leaf extract. At the extract concentration of 1250 mg/L, the antifungal activity against the growth of F. oxysporum strains showed that A. saligna bark followed by C. maculatum leaf extracts had the highest inhibition percentage of fungal growth (IPFG%) against F. oxy 1 with 80% and 79.5%, F. oxy 2 with 86.44% and 78.9%, F. oxy 3 with 86.4% and 84.2%, F. oxy 4 with 84.2, and 82.1%, F. oxy 5 with 88.4% and 86.9%, and F. oxy 6 with 88.9, and 87.1%, respectively. For the antioxidant activity, ethanolic extract from C. maculatum leaves showed the lowest concentration that inhibited 50% of DPPH free radical (3.4 μg/mL). Additionally, the same extract observed the lowest concentration (4.5 μg/mL) that inhibited BCB bleaching. Conclusions: Extracts from A. saligna bark and C. maculatum leaves are considered potential candidates against the growth of F. oxysporum isolates—a wilt pathogen—and C. maculatum leaf as a potent antioxidant agent.

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Section: Discussionmentioning

confidence: 99%

Characterization of Phytoconstituents from Alcoholic Extracts of Four Woody Species and Their Potential Uses for Management of Six Fusarium oxysporum Isolates Identified from Some Plant Hosts

Salem

Mohamed²,

Ali

et al. 2021

Plants

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“…In contrast, it was reported (Martinez and Moyano, 2003) that enzymatic hydrolysis of the protein of casein, pea meal and soybean meal increased in the presence of tannic acid (1 to 5% w/w). However, tannins of Acacia nilotica pods differ from tannic acid as they contain epigallocatechin gallate (Ayoub, 1985;Barman and Rai, unpublished report). Decreased (p<0.05) digestibility of other nutrients was observed with increased level of tannin which was reflected through decreased (p<0.05) IVGP (ml/g) during the first 24 h (Table 4).…”

Section: Discussionmentioning

confidence: 99%

In vitro Nutrient Digestibility, Gas Production and Tannin Metabolites of Acacia nilotica Pods in Goats

Barman¹,

N.²

2008

Asian Australas. J. Anim. Sci

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Six total mixed rations (TMR) containing 0, 4, 6, 8, 10, 12% tannin (TMR I-VI), using Accacia nilotica pods as a source of tannin, were used to study the effect of Acacia tannin on in vitro nutrient digestibility and gas production in goats. This study also investigated the degraded products of Acacia nilotica tannin in goat rumen liquor. Degraded products of tannins were identified using high performance liquid chromatography (HPLC) at different hours of incubation. In vitro digestibility of dry matter (IVDMD) and organic matter (IVOMD) were similar in TMR II, and I, but declined (p<0.05) thereafter to a stable pattern until the concentration of tannin was raised to 10%. In vitro crude protein digestibility (IVCPD) decreased (p<0.05) with increased levels of tannins in the total mixed rations. Crude protein digestibility was much more affected than digestibility of dry matter and organic matter. In vitro gas production (IVGP) was also reduced (p<0.05) with increased levels of tannins in the TMR during the first 24 h of incubation and tended to increase (p>0.05) during 24-48 h of incubation. Gallic acid, phloroglucinol, resorcinol and catechin were identified at different hours of incubation. Phloroglucinol and catechin were the major end products of tannin degradation while gallate and resorcinol were produced in traces. It is inferred that in vitro nutrient digestibility was reduced by metabolites of Acacia nilotica tannins and ruminal microbes of goat were capable of withstanding up to 4% tannin of Acacia nilotica pods in the TMR without affecting in vitro nutrient digestibility.

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“…Its different parts are used in the treatment of different diseases like floral parts for gastrointestinal disorders 14 , leaves extracts for cancer and microbial infections 15,16 , roots extract for tuberculosis and liver disorders 17 bark for bacterial infections including cold, bronchitis, dysentery, biliousness, cholera, bleeding piles. 12,[18][19][20] The extract of bark contains the different form of tannins ((-)epigallocatechin-7-gallat, (-)epigallocatechin-5,7-digallat, dicatechin) 21,22 , flavonoids ( (+)-catechin-5-gallate, (+)-catechin-5,7-digallate, (+)-catechin-3′,5digallate, (+)-catechin-4′,5-digallate, (+)-mollisacacidin, apigenin-6,8-bis-C-β-D-glucopyranoside (vicenin), leucocyanadin, kaempferol-7-glucoside, acacetin, umbelliferon, caffeic acid, protocatechuic acid and m-catechol. 12,23,24 Keeping the rich antimicrobial bioactive collection of bark of A. nilotica, in mind, we planned to study its antileishmanial potential here.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis of Acacia nilotica and evaluation of its antileishmanial potential

Ali

Tabrez

Rahman

et al. 2021

Preprint

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Acacia nilotica is an important medicinal plant, found in Africa, the Middle East, and the Indian subcontinent. Every part of the plant possesses a wide array of biologically-active and therapeutically important compounds and has been used in the traditional system of medicine. We reported the antileishmanial activity of Acacia nilotica (A. nilotica) bark methanolic extract through in vitro assays and dissected the mechanism of its action through in silico studies. Bark methanolic extract exhibited anti-promastigote and anti-amastigote potency with IC50 value of 19.6 ± 0.9037 μg/ml and 77.52 ± 5.167 μg/ml respectively in time and dose-dependent manner.It showed very low cytotoxicity having a CC50 value of 432.7 ± 7.71 μg/ml on the human-macrophage cell line, THP-1. The major constituents identified by GC-MS analysis are 13-docosenoic acid (34.06%), lupeol (20.15 %), 9,12-octadecadienoic acid (9.92 %), and 6-octadecanoic acid (8.43 %) bind effectively with the potential drug-targets of Leishmania donovani (L. donovani) including sterol 24-c-methyltransferase (SMT), trypanothione reductase (TR), pteridine reductase (PTR1) and adenine phosphoribosyltransferase (APRT); suggest the possible mechanism of its antileishmanial action. The highest affinity with all these targets was shown by lupeol. The pharmacokinetic studies, predicted bioactivity scores, and acute toxicity studies of major extract constituents support safe antileishmanial drug candidates. This study proved the antileishmanial potential of bark-methanolic extract A. nilotica and its mechanism of action through the inhibition of potential drug targets of L. donovani.

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Flavanol Molluscicides from the Sudan Acacias

Cited by 17 publications

References 5 publications

Characterization of Phytoconstituents from Alcoholic Extracts of Four Woody Species and Their Potential Uses for Management of Six Fusarium oxysporum Isolates Identified from Some Plant Hosts

Characterization of Phytoconstituents from Alcoholic Extracts of Four Woody Species and Their Potential Uses for Management of Six Fusarium oxysporum Isolates Identified from Some Plant Hosts

In vitro Nutrient Digestibility, Gas Production and Tannin Metabolites of Acacia nilotica Pods in Goats

Phytochemical analysis of Acacia nilotica and evaluation of its antileishmanial potential

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Flavanol Molluscicides from the Sudan Acacias

Cited by 17 publications

References 5 publications

Characterization of Phytoconstituents from Alcoholic Extracts of Four Woody Species and Their Potential Uses for Management of Six Fusarium oxysporum Isolates Identified from Some Plant Hosts

Characterization of Phytoconstituents from Alcoholic Extracts of Four Woody Species and Their Potential Uses for Management of Six Fusarium oxysporum Isolates Identified from Some Plant Hosts

In vitro Nutrient Digestibility, Gas Production and Tannin Metabolites of Acacia nilotica Pods in Goats

Phytochemical analysis of Acacia nilotica and evaluation of its antileishmanial&nbsp;potential

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Phytochemical analysis of Acacia nilotica and evaluation of its antileishmanial potential