Flaviphenalenones A–C, three new phenalenone derivatives from the fungus Aspergillus flavipes PJ03-11

Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa

“…In conclusion, pycnidiophorones A-D (1-4), four new cytochalasans possessing a rare 6/5/6/6/5 pentacyclic skeleton, which was incorporated in a 12-oxatricyclo[6.3.1.0 2,7 ]dodecane core, and six known depsidones have been isolated from the crude extract of P. dispersa. Their structures were elucidated based on NMR spectroscopic data and ECD calculations.…”

“…Moreover, secondary metabolites from wetland-derived fungi showed a wide range of bioactivities including antibacterial, antifungal, cytotoxic, and a-glucosidase inhibitory activities. [7][8][9][10][11][12][13][14] Our prior investigations of the wetland-derived fungus Paraconiothyrium sporulosum grown in liquid-substrate fermentation cultures led to isolation of a series of bioactive metabolites. 15 As part of our program to discover structurally unique and biologically active secondary metabolites from wetland-derived fungi, a strain of Pycnidiophora dispersa, isolated from the Baiyangdian Lake, Hebei Province, People's Republic of China, was subjected to scale-up fermentation on rice.…”

Natural Products Research in China From 2015 to 2016

“…The wetland mud-derived fungus Aspergillus flavipes PJ03-11 (Red Beach National Nature Reserve, Liaoning, China) produced three novel butenolides (Zhang et al, 2016f ) and three new phenalenone derivatives, flaviphenalenones A–C (Zhang et al, 2016e ). Aspulvinones P ( 168 ), Q ( 169 ), and methybutyrolactone III ( 170 ), as well as flaviphenalenones B ( 171 ) and C ( 172 ) showed more potent α-glucosidase inhibitory activities than acarbose (0.685 mM) with IC 50 values of 0.079, 0022, 0.016, 0.095, and 0.079 mM, respectively.…”

Study on Secondary Metabolites of Endophytic Fungus, Aspergillus fumigatus, from Crocus sativus L. Guided byUHPLC-HRMS/MS-Based Molecular Network

“…It is also utilized in processing agricultural products, like biological fertilizers and as a biological control agent. Studies have shown that the genus Aspergillus is a rich source of biologically active secondary metabolites such as alkaloids [ 1 , 2 ], steroids [ 1 , 3 ], terpenes [ 4 ], quinones [ 5 ], and polyketides [ 6 ], with antimicrobial [ 1 , 7 , 8 ], antitumor [ 9 ], antioxidant [ 10 ], and anti-inflammatory [ 11 ] activities.…”