Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo

Quantitative Structure–Cytotoxicity Relationship of Chalcones

“…Chalcones are promising lead antitumor/chemopreventive drugs due to three different activities: antioxidant, cytotoxic, and apoptosis induction (2). Several studies with murine xenograft models have shown that administration of chalcones significantly reduced the tumor volume by inducing apoptosis (3)(4)(5)(6)(7)(8)(9)(10). The tumor specificity of chalcones has been reported in comparing sensitivity of hepatocarcinoma HepG2 cells to normal liver AML12 cells (11); osterosarcoma to bone marrow and smallintestinal epithelial cells (12); murine acute lymphoblastic leukemia cells L-1210 to normal human lymphocytes (13); and human prostate cancer cells PC3 and DU145 to normal human prostate epithelial cells (14).…”

An Overview on Cardamonin

“…3 Cardamonin's name comes from the fact that it can be found in cardamom spice (Fig. 4), but since the first article where it was described, 22 it has been found in many other (some of them edible) plant species, such as Alpinia blepharocalyx, 23,24 Alpinia gagnepainii, 25 Alpinia conchigera, 26,27 Alpinia hainanensis, [28][29][30][31][32][33][34][35][36][37][38][39][40] Alpinia malaccensis, 41 Alpinia mutica, 42,43 Alpinia pricei, 44 Alpinia rafflesiana, [45][46][47][48] Alpinia speciosa, 22,49,50 Amomum subulatum, 51 Artemisia absinthium, 52 Boesenbergia pandurata, [53][54][55][56][57][58][59][60] Boesenbergia rotunda, 61,62 Carya cathayensis, 63 Cedrelopsis grevei, 64 Combretum apiculatum, 65 Comptonia pere...…”

“…67 Lin et al 44 tested some chalcones effects, including cardamonin, upon cell death of human squamous carcinoma KB cells. With solutions of 74 lM, a viability of ca.…”

Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo) Plants

“…[67] In addition, flavokawain B treatment (0.75 mg/kg/day) significantly inhibited in vivo growth of human KB cell-derived tumor xenografts in nude mice. [68]…”

“…[66] In KB cells, the induction of apoptosis by flavokawain B may involve both the death receptor and mitochondrial pathway. [68] Flavokawain B also has a pro-apoptotic effect on synovial sarcomas cell lines. [85] Flavokawain B induces apoptosis of non-small cell lung cancer H-460 cells via Bax-initiated mitochondrial and c-Jun N-terminal kinase (JNK) pathways.…”