Flavone Composition and Antihypercholesterolemic and Antihyperglycemic Activities of Chrysanthemum coronarium L.

Abd‐Alla, Howaida I.; Albalawy, Marzougah A; Aly, Hanan F.; Shalaby, Nagwa M. M.; Shaker, Kamel H.

doi:10.5560/znc.2013-0115

Cited by 22 publications

(13 citation statements)

References 38 publications

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“…It has long been prescribed for the treatment of eye diseases in Chinese traditional preparations. Recent studies have shown that flavonoids in chrysanthemum are more likely to contribute to curing eye diseases [1] , [21] , [23] , [30] , [41] . Despite of recent progress, the definite component of chrysanthemum and the mechanism of action in the way chrysanthemum contributes to vision remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Diosmetin protects against retinal injury via reduction of DNA damage and oxidative stress

et al. 2016

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Visual impairment is a global public health problem that needs new candidate drugs. Chrysanthemum is a traditional Chinese drug, famous for its eye-protective function, with an unclear mechanism of action. To determine how chrysanthemum contributes to vision, we identified, for the first time, the component of chrysanthemum, diosmetin (DIO), which acts in protecting the injured retina in an adriamycin (ADR) improving model. We observed that DIO could attenuate the apoptosis of retinal cells in Sprague–Dawley rats and verified this effect in cultured human retinal pigment epithelium (RPE) cells, ARPE-19. Our further study on the mechanism revealed the counteractive effect of DIO on the attenuation of DNA damage and oxidative stress, which occurs in a wide range of retinal disorders. These results collectively promise the potential value of DIO as a retinal-protective agent for disorders that lead to blindness. In addition, we identified, for the first time, the component of chrysanthemum, DIO, which acts in protecting the injured retina.

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Section: Introductionmentioning

confidence: 99%

Diosmetin protects against retinal injury via reduction of DNA damage and oxidative stress

et al. 2016

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“…After injection, animals had free access for food, water and were given 5% glucose solution to drink overnight to encounter hypoglycemic shock. Animals were checked daily for the presence of glycosuria [14]. Animals were considered to be diabetic if glycosuria was present for 3 consecutive days.…”

Section: Induction Of Hyperglycemiamentioning

confidence: 99%

“…Group 4: Rats were considered as hyperglycemic (HG)-HC which classified as follows: Groups 5 and 6: HG-HC group rats oral administered 250 mg/kg BW crude ethanol extracts of MGE and NPE for 30 days, respectively. Group 7: HG-HC rats orally administered 2 mg/kg BW of the anti-HC reference drug; atorvastatin [4,14] and the anti-HG glibenclamide reference drug at the dose of 10 mg/kg BW daily for 30 days [13,14].…”

Section: Dose Regimens and Route Of Administrationmentioning

confidence: 99%

Bioinformatics: Inflammatory Cytokines and Attenuation of Diabetes Hypercholesterolemia-Induced Renal Injury Using Morning Glory and Necklace Pod Extracts

Aly

Abd‐Alla²,

Ali³

et al. 2017

Asian J Pharm Clin Res

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Objective: The present research in bioinformatics focuses on pharmacological effects of morning glory and necklace pod ethanolic extracts (MGE and NPE) on some biochemical parameters in high fat diet-induced hypercholesterolemia and streptozotocin-induced hyperglycemia in rats.Methods: Compared to atorvastatin; an anti-hypercholesterolemic (HC) and glibenclamide; an antidiabetic drug. Endothelium activation markers of soluble vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1 were determined using enzyme-linked immunosorbent assay. Creatinine, urea, and inflammatory biomarkers; C-reactive protein (CRP) and pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin (IL)-10 levels were also measured in serum of different therapeutic groups.Results: Significant decrease in ICAM-1 level with MGE and NPE supplemented to normal rats as compared to untreated control with percentages decrease 17.80 and 12.00% was observed. Insignificant change was detected in VCAM-1 level. Profound amelioration in CRP, total urea and creatinine levels by NPE treatment. Creatinine, urea, CRP, and TNF-α level were significantly increased in hyperglycemic (HG)-HC rats. However, IL-10 level showed a significant decrease. Meanwhile, histopathological investigation of the kidney and heart was carried out. Image recognition system for kidney and heart images was developed to diagnose their diseases. Tested extract attenuated creatinine, urea, CRP, and TNF-α level. Hyperglycemia and hypercholesterolemia linked kidney disorders were relieved. Conclusion:In vivo oral administration with each extract declared suppression of cytokines mediated inflammation, vascular function leading to infiltration reduction of renal macrophage together with lowering in kidney indices and ameliorate renal tissues architectures in HG-HC rats.

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“…Flavanols and flavonols, condensed tannins (proanthocyanidins), hydrolysable tannins (ellagitannins and gallotannins), stilbenes, anthocyanins, and phenolic acids were reported as the most commonly found polyphenols in Morus fruits [13]. Polyphenols content may reduce plasma TG, TC, and LDL-C in hyperlipidemic rats [15,44].…”

Section: Discussionmentioning

confidence: 99%

Berries Supplementation Modulates Body Weight and Metabolic Deteriorations in Obese Rats

Baz

Aly

2018

Asian J Pharm Clin Res

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Objective:The aim of the present work is to investigate the potential of purple (Morus rubra [MR]) and white (Morus alba [MA]) berry supplementation to modulate body weight (BW) and metabolic deteriorations in obese Wistar male rats.Methods: Seventy rats weighing 150.00±10 g (mean±standard deviation) were used; the rats were randomly divided into seven groups of 10 rats each. Obesity was induced by feeding animals high-fat diet (HFD), for 6 consecutive weeks then treated with the purple (MR) and white (MA) berry ethanol extracts for 6 weeks in a dose 300 mg/Kg BW. BW gain, food intake fecal fat content, food consumptions were determined. The fats and organs such as liver, kidney, and heart were also weighed. Lipid profiles included triglyceride, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, as well as liverenzymes; alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, γ-glutamyltransferase (γ-GGT), and leptin were also determined.Results: Treatment of obese rats with white and purple berries showed significant reduction in BW reached to 23.68% with MR and 21.19% with MA berries compared to Orlistat (31.16%). Liver weight, visceral fat, and liver enzyme activities were also markedly ameliorated. In addition, lipid profile biomarkers were improved on treated obese rats with both Morus species. In addition, increase in fecal fat (250.73% and 256.25%, for MR and MA, respectively) was noticed while blood glucose, insulin, leptin levels, and pancreatic lipase activity was improved. In addition, supplementing obese rats with both Morus species extract significantly increase food intake reached 33.33% and 36.66%, for MR and MA, respectively. Conclusion:The ameliorating effect of both Morus extracts may be attributed to polyphenolic rich compounds which have antioxidant properties, suppressed lipid synthesis in hepatic tissue and inhibited pancreatic lipase activity which consequently recommended using as a promising antiobesity agents. El-Baz et al.different physiological biomarkers related metabolic changes including liver function enzyme activities, BW gain percentage, organ weight, food intake, visceral and fecal fats percentages, blood glucose, insulin, and leptin levels as well as pancreatic lipase activity. MATERIALS AND METHODS Collection of plant materialFresh fruits of white Morus alba (MA) and purple Morus rubra (MR) were collected in the Delta region, Egypt. The berries were selected according to uniformity of shape and color. The identification of the plant was confirmed by Therese Labib, Herbarium Section, El-Orman Botanical Garden, Giza, and Egypt. The fresh fruit samples were cleaned, stored in polyethylene bags and frozen at −20°C, till further use.

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Flavone Composition and Antihypercholesterolemic and Antihyperglycemic Activities of Chrysanthemum coronarium L.

Cited by 22 publications

References 38 publications

Diosmetin protects against retinal injury via reduction of DNA damage and oxidative stress

Diosmetin protects against retinal injury via reduction of DNA damage and oxidative stress

Bioinformatics: Inflammatory Cytokines and Attenuation of Diabetes Hypercholesterolemia-Induced Renal Injury Using Morning Glory and Necklace Pod Extracts

Berries Supplementation Modulates Body Weight and Metabolic Deteriorations in Obese Rats

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