Flavone glycosides of Salvia triloba

Abdalla, Mohamed F.; Saleh, Nabiel A.M.; Gabr, S.; Abu-Eyta, Ahmed M.; El-Said, Hani

doi:10.1016/0031-9422(83)80044-2

Cited by 20 publications

(7 citation statements)

References 12 publications

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“…These features allowed identifying it as chrysoeriol hexuronide (methylluteolin hexuronide) [ 19 , 20 ]. The glycosides derivative of the methylated flavone was previously been described in other species of Salvia [ 21 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

Determination of the Phenolic Profile and Antioxidant Properties of Salvia viridis L. Shoots: A Comparison of Aqueous and Hydroethanolic Extracts

Grzegorczyk-Karolak

Kiss

2018

Molecules

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Salvia viridis L. is an annual herb used in Mediterranean medicine. The purpose of this study was to determine the polyphenol profile of aqueous (decoction and infusion) and hydroethanolic extracts of aerial parts of field-grown S. viridis and to evaluate their antioxidant activity. The polyphenol profiling was performed via UPLC-DAD/ESI-MS. Additionally, the total polyphenol content in extracts tested were determined by UV-Vis spectrophotometry using the Folin-Ciocalteu assay. The antioxidant effect was evaluated by the FRAP, DPPH, ABTS, O2•− scavenging and TBARS methods. The hydroethanolic extract gave the highest content of total phenolic compounds, followed by the infusion. The UPLC-DAD/ESI-MS analysis of extracts showed a total of 19 phenolic compounds identified as flavonoids (four compounds), phenylethanoids (eight compounds) and phenolic acids (seven compounds). Rosmarinic acid was the predominant phenolic acid, verbascoside was the predominant phenylethanoid, while apigenin glucuronide or methylluteolin glucuronide, depending on the sample, were the predominant flavonoids in the analyzed extracts. The presence of a high polyphenol level indicated a high antioxidant activity of both the infusion and the hydroalcoholic extract. These results indicate that S. viridis is a rich resource of phenolic compounds and can be used in dietary applications with the potential to reduce oxidative stress.

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Section: Resultsmentioning

confidence: 99%

Determination of the Phenolic Profile and Antioxidant Properties of Salvia viridis L. Shoots: A Comparison of Aqueous and Hydroethanolic Extracts

Grzegorczyk-Karolak

Kiss

2018

Molecules

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“…However, specific plant lineages have characteristic flavonoids conjugated with specific sugar moieties as their specialized metabolites. Flavonoid 7-Oglucuronide is commonly observed with flavonoid 7-O-glucoside in plants within the Lamiales order, such as Perilla frutescens (dietary herb), Antirrhinum majus (snapdragon flower), and Scutellaria baicalensis (a plant whose dried roots are used in Chinese natural medicine) (Figure 1) (Harborne, 1963;Asen et al, 1972;Subramanian and Nair, 1973;Abdalla et al, 1983;Tomimori et al, 1984;Kawasaki et al, 1988;Yoshida et al, 1993;Zhang et al, 1997;Hirotani et al, 1998;Harborne and Baxter, 1999;Huang et al, 1999;Yamazaki et al, 2003;Bremer et al, 2003;APG II, 2003, Wortley et al, 2005. Baicalin, a flavone 7-Oglucuronide, is predominantly accumulated in Scutellaria roots and has been well studied due to its beneficial effects on human health, such as its anti-allergic, antiviral, anti-inflammatory, and intestinal a-glucosidase inhibitory properties (Shibata and Hattori, 1931;Kida et al, 1982;Nishioka et al, 1998;Gao et al, 1999;Chou et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Local Differentiation of Sugar Donor Specificity of Flavonoid Glycosyltransferase in Lamiales

et al. 2009

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Flavonoids are most commonly conjugated with various sugar moieties by UDP-sugar:glycosyltransferases (UGTs) in a lineage-specific manner. Generally, the phylogenetics and regiospecificity of flavonoid UGTs are correlated, indicating that the regiospecificity of UGT differentiated prior to speciation. By contrast, it is unclear how the sugar donor specificity of UGTs evolved. Here, we report the biochemical, homology-modeled, and phylogenetic characterization of flavonoid 7-Oglucuronosyltransferases (F7GAT), which is responsible for producing specialized metabolites in Lamiales plants. All of the Lamiales F7GATs were found to be members of the UGT88-related cluster and specifically used UDP-glucuronic acid (UDPGA). We identified an Arg residue that is specifically conserved in the PSPG box in the Lamiales F7GATs. Substitution of this Arg with Trp was sufficient to convert the sugar donor specificity of the Lamiales F7GATs from UDPGA to UDPglucose. Homology modeling of the Lamiales F7GAT suggested that the Arg residue plays a critical role in the specific recognition of anionic carboxylate of the glucuronic acid moiety of UDPGA with its cationic guanidinium moiety. These results support the hypothesis that differentiation of sugar donor specificity of UGTs occurred locally, in specific plant lineages, after establishment of general regiospecificity for the sugar acceptor. Thus, the plasticity of sugar donor specificity explains, in part, the extraordinary structural diversification of phytochemicals.

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“…Mints also have antibacterial and antiviral activities. Lamiaceae is rich in flavonoids and have been reported to contain flavanones (Ulubelen & Brieskorn, 1977), flavone-C-glycosides (Abdallah et al, 1983), flavonoles and flavones (Wollenweber, 1974).…”

Section: Introductionmentioning

confidence: 99%