Flavones in Extracts of<i>Cimicifuga racemosa</i>

Struck, D.; Tegtmeier, M.; Harnischfeger, G.

doi:10.1055/s-2006-957682

Cited by 48 publications

(29 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent reports on the presence of formononetin, an estrogenic isoflavone, remain controversial. While we and others could not confirm its presence in black cohosh [14][15][16], there is one recent positive report [17]. Actein, 23-epi-26-deoxyactein (syn.…”

Section: Introductioncontrasting

confidence: 81%

“…The phenolic constituents were cimicifugic acids A (10) and B (11), cimifugin (12), cimiracemates A (13) and B (14), caffeic acid (15), ferulic acid (16), and isoferulic acid (17). Compounds 1-7 and 10-12 were isolated from the Cimicifuga species by procedures described in the literature [3,24], and were identified by NMR spectroscopy.…”

Section: Plant Materials and Standardsmentioning

confidence: 99%

See 1 more Smart Citation

Cimicifuga species identification by high performance liquid chromatography–photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products

He¹,

Pauli

Zheng³

et al. 2006

Journal of Chromatography A

107

View full text Add to dashboard Cite

Black cohosh has become one of the most important herbal products in the U.S. dietary supplements market. It is manufactured from roots and rhizomes of Cimicifuga racemosa (Ranunculaceae). Botanical identification of the raw starting material is a key step in the quality control of black cohosh preparations. The present report summarizes a fingerprinting approach based on HPLC-PDA/MS/ ELSD that has been developed and validated using a total of ten Cimicifuga species. These include three North American species, C. racemosa, C. americana, C. rubifolia, and seven Asian species, C. acerina, C. biternat, C. dahurica, C. heracleifolia, C. japonica, C. foetida, and C. simplex. The chemotaxonomic distinctiveness of the HPLC fingerprints allows identification of all ten Cimicifuga species. The triterpene glycosides cimigenol-3-O-arabinoside (3), cimifugin (12), and cimifugin-3-O-glucoside (18) were determined to be suitable species-specific markers for the distinction of C. racemosa from the other Cimicifuga species. In addition to identification, the fingerprint method provided insight into chemical interconversion processes occurring between the diverse triterpene glycosides contained in black cohosh. The reported method has proven its usefulness in the botanical standardization and quality control of black cohosh products.

show abstract

Section: Introductioncontrasting

confidence: 81%

Section: Plant Materials and Standardsmentioning

confidence: 99%

Cimicifuga species identification by high performance liquid chromatography–photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products

He¹,

Pauli

Zheng³

et al. 2006

Journal of Chromatography A

107

View full text Add to dashboard Cite

show abstract

“…The authors speculated that black cohosh may work through estrogen-like compounds , but to date this has not been established. Others have looked for and not found formononetin in black cohosh extracts (Struck et al, 1997;Kennelly et al, 2002).…”

Section: Black Cohoshmentioning

confidence: 99%

Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

407

278

View full text Add to dashboard Cite

Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. The number of articles published on phytoestrogens has risen dramatically in the past couple decades. Further research continues to demonstrate the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. This paper discusses the classification of phytoestrogens, methods of identification, their proposed mechanisms of action and botanical sources for phytoestrogens. The effects of phytoestrogens on breast and prostate cancers, cardiovascular disease, menopausal symptoms and osteoporosis will also be examined including research on benefits and risks.

show abstract

“…However, the details of its actions remain unclear. Investigations into the chemical constituents of CR revealed alkaloids (19), isoflavones (52), phenylpropanoids (8), and more than 20 highly oxygenated triterpene glycosides with cycloartane skeletons, which are secondary metabolites believed to have biological effects (28,56). We recently observed anti-stress activities of CR extract in mice (31): a single oral administration of CR extract (200-1,000 mg/kg) significantly attenuated plasma corticosterone and aspartate aminotransferase (AST) levels that had been increased as a result of enforced immobilization.…”

mentioning

confidence: 99%