Flavonoid Components, Distribution, and Biological Activities in Taxus: A review

Abstract

Taxus, also known as “gold in plants” because of the famous agents with emphases on Taxol and Docetaxel, is a genus of the family Taxaceae, distributed almost around the world. The plants hold an important place in traditional medicine in China, and its products are used for treating treat dysuria, swelling and pain, diabetes, and irregular menstruation in women. In order to make a further study and better application of Taxus plants for the future, cited references from between 1958 and 2022 were collected from the Web of Science, the China National Knowledge Internet (CNKI), SciFinder, and Google Scholar, and the chemical structures, distribution, and bioactivity of flavonoids identified from Taxus samples were summed up in the research. So far, 59 flavonoids in total with different skeletons were identified from Taxus plants, presenting special characteristics of compound distribution. These compounds have been reported to display significant antibacterial, antiaging, anti-Alzheimer’s, antidiabetes, anticancer, antidepressant, antileishmaniasis, anti-inflammatory, antinociceptive and antiallergic, antivirus, antilipase, neuronal protective, and hepatic-protective activities, as well as promotion of melanogenesis. Flavonoids represent a good example of the utilization of the Taxus species. In the future, further pharmacological and clinical experiments for flavonoids could be accomplished to promote the preparation of relative drugs.

Mass Spectrometry-Imaging Analysis of Active Ingredients in the Leaves of Taxus cuspidata

“…So far, a large number of flavonoids with different skeletons were isolated from Taxus plants. Flavonoids have potential benefits for human health and were reported to be play significant antibacterial, anti-aging, anti-Alzheimer’s, antidiabetic and anticancer . Our data suggest that the leaves of T.…”

“…Ascorbic acid, carotenoids, and polyphenols extracted from Taxus baccata red arils exhibit strong antioxidant activities . A number of flavonoids with diverse skeleton structures were reported to exhibit significant antibacterial, antiaging, and antiviral activities . Using the high-performance liquid chromatography with diode-array detection method, several phenolic compounds with antioxidant and anticancer activities were determined in the Taxus cuspidata bark extracts .…”

“… 9 A number of flavonoids with diverse skeleton structures were reported to exhibit significant antibacterial, antiaging, and antiviral activities. 10 Using the high-performance liquid chromatography with diode-array detection method, several phenolic compounds with antioxidant and anticancer activities were determined in the Taxus cuspidata bark extracts. 11 α-Conidendrin, a polyphenolic compound extracted from Taxus yunnanensis , exhibits significant anticancer activity on human breast cancer cell lines.…”

Composition and Antioxidative and Antibacterial Activities of the Essential Oil from Farfugium japonicum

“…According to previous studies [ 12 , 13 ], the terpenoids and phenols in volatiles are recognized for their antioxidant and antibacterial components. However, there are some important factors affecting the quality and ingredient composition in terpenoids and phenols, such as the extraction methods used, plants organs, and compounds ingredients etc.…”

Sinensetin Attenuated Macrophagic NLRP3 Inflammasomes Formation via SIRT1-NRF2 Signaling

“…Flavonoid derives from various vegetables and fruits, at least including green tea, citrus fruits, and even onion. Accumulating evidence indicated that flavonoid plays important roles in antivirus and antitumor response and in improving cardiovascular diseases . Recently, emerging studies highlighted that sinensetin (SNS), one of the flavone aglycones, exhibits various bioactivities on anti-inflammation, antioxidant, antitumor antimicrobial, and antiobesity. , SNS served as an inhibitor to target GLUT1 to facilitate sorafenib-induced cytotoxicity of cancer cells, which might contribute to overcoming chemoresistance in cancer treatment .…”