Flavonoid Compounds from the Leaves of<i>Kalanchoe prolifera</i>and Their Cytotoxic Activity against P-388 Murine Leukimia Cells

Aisyah, Lilis Siti; Yun, Yenny Febriani; Herlina, Tati; Julaeha, Euis; Zainuddin, Achmad; Nurfarida, Ida; Hidayat, Ace Tatang; Supratman, Unang; Shiono, Yoshihito

doi:10.20307/nps.2017.23.2.139

Cited by 45 publications

(25 citation statements)

References 26 publications

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“…The molecular weight (MW) of 1 was determined to be 302 amu based on the molecular ion peak ( ; one conjugated ketone carbon signal at δ C 177.12 (C-4) suggested that 1 was a flavonol. 1 was identified to be quercetin through intensive analysis of 2D-NMR (i.e., gHSQC and gHMBC) data as well comparison of the spectroscopic data with reported literature [16].…”

Section: Resultsmentioning

confidence: 99%

Pharmacological activity and quantitative analysis of flavonoids isolated from the flowers of Begonia semperflorens Link et Otto

Kwon

Lee

et al. 2019

Appl Biol Chem

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Begonia semperflorens Link et Otto has been broadly raised up for ornamental purpose as well comestible blossom. As the reproductive structures of phanerogams, flowers contain various secondary metabolites and have many biological activities. Accordingly, we began the contrivance for isolation and analysis of flavonoids contained in B. semperflorens flowers. MeOH extraction of B. semperflorens followed solvent fractionation was prosecuted. Column chromatography of non-polar fraction gave four flavonoids using several resins. Identification of the flavonols were established as quercetin (1), kaempferol (2), astragalin (3), and isoquercetin (4) by interpreting a variety of spectral information. Quercetin (1) and kaempferol (2) inhibited NO production and protected against t-BHP-induced oxidative stress. Kaempferol (2) also protected cell death of glutamate-treated HT22. Quantitative analysis of flavonoid content in B. semperflorens flowers was also performed using HPLC experiment.

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Section: Resultsmentioning

confidence: 99%

Pharmacological activity and quantitative analysis of flavonoids isolated from the flowers of Begonia semperflorens Link et Otto

Kwon

Lee

et al. 2019

Appl Biol Chem

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“…for C 30 H 39 O 7 m/z 511.2696) and nuclear magnetic resonance (NMR) data (Table 1), indicating the presence of twelve degrees of unsaturation. The ultraviolet (UV) spectrum showed maximum absorption at 284 nm, indicating the presence of an α, β-unsaturated ketone [13,14]. Infrared (IR) absorptions spectra suggested the presence of hydroxyl (3509 cm −1 ), aliphatic (2929 cm −1 ), carbonyl ester (1744 cm −1 ), α, β-unsaturated carbonyl (1670 cm −1 ), olefinic (1502 cm −1 ), gem-dimethyl (1366 and 1386 cm −1 ) and ether groups (1248 cm -14).…”

Section: Resultsmentioning

confidence: 99%

A new havanensin-type limonoid from Chisocheton macrophyllus

et al. 2021

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A new havanensin-type limonoid, 16β-hydroxydysobinin (1), along with four known limonoids (2–5), have been isolated from the seeds of Chisocheton macrophyllus. The chemical structure of the new compound was determined by referencing spectroscopic data, and by comparison to those related spectra previously reported. Each compound was evaluated for their cytotoxic effects against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and display no significant activity.

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“…The NMR profiling of these fractions suggested the presence of flavonoids and iridoids. In fact, the known flavonoids, rutin ( 8 ) [ 28 ], kaempferol-7- O -rhamnosyl-3- O -glucopyranoside ( 9 ) [ 29 ], kaempferol-3- O -rutinoside ( 10 ) [ 30 ], and kaempferol-3- O -glucopyranoside ( 11 ) [ 28 ] were identified as constituents of fraction G ( Figure 3 ), along with two acylated iridoid glycosides ( 12 – 13 , Figure 5 ), one of them ( 13 ) isolated and characterized for the first time.…”

Section: Resultsmentioning

confidence: 99%

Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata

et al. 2021

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Plants are the everlasting source of a wide spectrum of specialized metabolites, characterized by wide variability in term of chemical structures and different biological properties such antiviral activity. In the search for novel antiviral agents against Human Immunodeficiency Virus type 1 (HIV-1) from plants, the phytochemical investigation of Scrophularia trifoliata L. led us to isolate and characterize four flavonols glycosides along with nine iridoid glycosides, two of them, 5 and 13, described for the first time. In the present study, we investigated, for the first time, the contents of a methanol extract of S. trifoliata leaves, in order to explore the potential antiviral activity against HIV-1. The antiviral activity was evaluated in biochemical assays for the inhibition of HIV-1Reverse Transcriptase (RT)-associated Ribonuclease H (RNase H) activity and HIV-1 Integrase (IN). Three isolated flavonoids, rutin, kaempferol-7-O-rhamnosyl-3-O-glucopyranoside, and kaempferol-3-O-glucopyranoside, 8–10, inhibited specifically the HIV-1 IN activity at submicromolar concentration, with the latter being the most potent, showing an IC50 value of 24 nM.

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Flavonoid Compounds from the Leaves ofKalanchoe proliferaand Their Cytotoxic Activity against P-388 Murine Leukimia Cells

Cited by 45 publications

References 26 publications

Pharmacological activity and quantitative analysis of flavonoids isolated from the flowers of Begonia semperflorens Link et Otto

Pharmacological activity and quantitative analysis of flavonoids isolated from the flowers of Begonia semperflorens Link et Otto

A new havanensin-type limonoid from Chisocheton macrophyllus

Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata

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