Flavonoid constituents and biological screening ofAstragalus bombycinusBoiss.

Ibrahim, Lamyaa F.; Marzouk, Mona M.; Hussein, Sameh R.; Kawashty, Salwa A.; Mahmoud, Khaled; Saleh, Nabiel A.M.

doi:10.1080/14786419.2012.701213

Cited by 45 publications

(31 citation statements)

References 11 publications

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“…Modern pharmacological research suggests the Astragalus membranaceus has positive effects such as improving cardiac function, 6 promoting angiogenesis, 7 regulating blood glucose, 8 being an anti-tumor agent, 9 and increasing immunomodulatory activity. 10 The principle active constituents of Astragalus membranaceus are saponins, flavonoids, and polysaccharides, 11 but it also includes components such as anthraquinones, alkaloids, amino acids, β-sitosterol, and metallic elements. 12 Astragaloside IV (AS-IV) is a lanolin alcohol-derived tetracyclic triterpene saponin extracted from Astragalus membranaceus .…”

Section: Introductionmentioning

confidence: 99%

Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases

Tan¹,

Chen²,

Li³

2020

DDDT

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Cardiovascular disease (CVD), the number one cause of death worldwide, has always been the focus of clinical and scientific research. Due to the high number of deaths each year, it is essential to find alternative therapies that are safe and effective with minimal side effects. Traditional Chinese medicine (TCM) has a long history of significant impact on the treatment of CVDs. The mode of action of natural active ingredients of drugs and the development of new drugs are currently hot topics in research on TCM. Astragalus membranaceus is a commonly used Chinese medicinal herb. Previous studies have shown that Astragalus membranaceus has anti-tumor properties and can regulate metabolism, enhance immunity, and strengthen the heart. Astragaloside IV (AS-IV) is the active ingredient of Astragalus membranaceus , which has a prominent role in cardiovascular diseases. AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis. It can also regulate blood glucose and blood lipid levels and reduce the risk of cardiovascular diseases. In this paper, the mechanism of AS-IV intervention in cardiovascular diseases in recent years is reviewed in order to provide a reference for future research and new drug development.

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Section: Introductionmentioning

confidence: 99%

Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases

Tan¹,

Chen²,

Li³

2020

DDDT

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“…var . mongholicus, a common herbal medicine, contains polysaccharides, saponins, flavonoids, anthraquinones, alkaloids, amino acids, β-sitosterol, and metallic elements and has long been used as a feed additive in the livestock and poultry industries in China (Ibrahim et al 2013 ; Li et al 2009 ). The major polysaccharides present in Astragalus are mannose, d -glucose, d -galactose, xylose, and l -arabinose (Kallon et al 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Fermented Astragalus in diet altered the composition of fecal microbiota in broiler chickens

et al. 2018

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The composition and function of the intestinal microbiota play important roles in digestion and degradation of herbal medicines (HMs). However, few studies have examined the relationship between the fecal microbiota and HMs. In this study the effect of unfermented Astragalus (UA) and fermented Astragalus (FA) on growth performance, serum biochemical parameters, and fecal microbiota was evaluated in broiler chickens. In total, 180 one-day-old broiler chickens (Avian breeds) were randomly assigned to a control (C) group fed a basal diet, an unfermented (U) group fed a basal diet containing 0.5% UA, or a fermented (F) group fed a basal diet containing 0.5% FA, for 42 days. The F/G ratio was lower in F and U groups than in C group from 22 to 42 days (P < 0.05). Glutathione superoxide dismutase, antioxidant capacity, and total superoxide dismutase were higher, whereas malondialdehyde was lower in F group than in C and U groups from 1 to 21 days and from 22 to 42 days (P < 0.05). Fecal microbiota were profiled on an Illumina MiSeq platform following PCR amplification of the V4 region of the 16S rRNA gene. At the genus level Lactobacillus was the most abundant genus on day 7 in F group. Importantly, a potentially pathogenic genus, Enterococcus, was less abundant in the U and F groups than in the C group on day 35 (P < 0.05). These results indicate that dietary supplementation with 0.5% FA has beneficial effects on growth performance, serum biochemical parameters and fecal microbiota of broiler chickens.

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“…reported a new flavone, C-glycoside from Astragalus bombycinus . [ 18 ] Flavonols are the most frequently isolated compounds. Among them quercetin, kaempferol, and their glycosides were found in higher number Astragalus species.…”

Section: Flavonoids From the Genus Astragalusmentioning

confidence: 99%

Flavonoids from the genus Astragalus: Phytochemistry and biological activity

et al. 2016

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Flavonoids, the most common plant polyphenols are widely distributed in every species and possess a broad range of pharmacological activities. The genus Astragalus is the largest in the Fabaceae family with more than 2,500 species spread. They are known to contain different metabolites such as flavonoids, saponins, and polysaccharides. Plants from the genus have been used in the traditional medicine of many countries for centuries. This paper is focused on the large group of flavonoid compounds. Details on structure as well as information about the pharmacological properties of flavonoids, isolated from Astragalus species have been discussed. This review is based on publications until the first half of 2014 and includes also the results from our phytochemical investigations of the genus.

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Flavonoid constituents and biological screening ofAstragalus bombycinusBoiss.

Cited by 45 publications

References 11 publications

<p>Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases</p>

<p>Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases</p>

Fermented Astragalus in diet altered the composition of fecal microbiota in broiler chickens

Flavonoids from the genus Astragalus: Phytochemistry and biological activity

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