Flavonoid glycosides in the shoot system of Okinawa Taumu (Colocasia esculenta S.)

Leong, Abraham Cheng-Ning; Kinjo, Yoshinori; Tako, Masakuni; Iwasaki, Hiromichi; Oku, Hirosuke; Tamaki, Hiroyuki

doi:10.1016/j.foodchem.2009.07.004

Cited by 47 publications

(39 citation statements)

References 19 publications

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“….4 (C-1 00 ), 70.8 (C-2 00 ), 78.7 (C-3 00 ), 70.6 (C-4 00 ), 81.9 (C-5 00 ), 61.3 (C-6 00 ). Comparison of these data with the literature led to the identification of this compound as vitexin (Leong et al, 2010). compound is identified as quercetin (Guvenalp & Demirezer, 2005;Markham, 1978).…”

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confidence: 97%

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Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Hassan

Matloub

Aboutabl

et al. 2015

Pharmaceutical Biology

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Context: Cajanus cajan L. (Fabaceae), a food crop, is widely used in traditional medicine. Objectives: The phytochemical composition of C. cajan seeds and evaluation of the antiinflammatory, immunomodulatory, antinociceptive, and antioxidant activities were studied. Materials and methods: Unsaponifiable matter and fatty acids were analyzed by GC and GC/MS. The n-butanol fraction was chromatographed on polyamide column. The anti-inflammatory activity of hexane extract (200 and 400 mg/kg, p.o.) was evaluated using the carrageenan-induced rat paw edema at 1, 2, and 3 h. The serum tumor necrosis factor-a, interleukin-6, and immunoglobulin G levels were detected by ELISA. The hexane extract antinociceptive activity was determined by adopting the writhing test in mice. DPPH radical scavenging, total reduction capability, and inhibition of lipid peroxidation of butanol fraction were evaluated. Results and conclusion: Twenty-one unsaponifiable compounds (mainly phytol, 2,6-di-(t-butyl)-4-hydroxy-4-methyl-2,5-cyclohexadiene-1-one, b-sitosterol, stigmasterol, and campesterol), as well as 12 fatty acids (primarily 9,12-octadecadienoic and palmitic acids) were identified in hexane extract of C. cajan seeds. n-BuOH fraction contains quercetin-3-O-b-D-glucopyranoside, orientin, vitexin, quercetin, luteolin, apigenin, and isorhamnetin. For the first time, quercetin-3-O-b-D-glucopyranoside is isolated from C. cajan plant. The hexane extract (200 and 400 mg/kg) inhibited carrageenaninduced inflammation by 85 and 95%, respectively, 3 h post-carrageenan challenge. This was accompanied by an 11 and 20%, 8 and 13%, respectively, decrease of TNF-a and IL-6, as well as significant decrease in IgG serum levels. Moreover, hexane extract (200 and 400 mg/kg) decreased the number of writhings by 61 and 83%, respectively. The butanol fraction showed DPPH radical scavenging (inhibitory concentration (IC 50 ) value: 9.07 mg/ml). ARTICLE HISTORY

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confidence: 97%

“…It was identified as orientin (Leong et al, 2010). .4 (C-1 00 ), 70.8 (C-2 00 ), 78.7 (C-3 00 ), 70.6 (C-4 00 ), 81.9 (C-5 00 ), 61.3 (C-6 00 ).…”

mentioning

confidence: 99%

Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Hassan

Matloub

Aboutabl

et al. 2015

Pharmaceutical Biology

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“…The structures of isolated compounds were identified by a combination of spectroscopic methods (MS, 1 D NMR and 2D NMR) and comparisons with the literature data as a mixture of quercetin 3-β-Ogalactopyranoside or hyperoside (1) and quercetin 3-β-Oglucopyranoside or isoquercitrin (1:1) (2) (Almeida et al, 1998;Costa et al, 2007;Ohguchi et al, 2010), quercetin 3-O-α-rhamnoside or quercitrin (3) (Zhong et al, 1997), luteolin 6-C-β-glucopyranoside or orientin (4) (Li et al, 2009), apigenin-6-C-glucoside or isovitexin (5) (Leong et al, 2010), kaempferol 3-O-α-rhamnoside (6) (Fossen et al, 1999) and lupenone (7) (Prachayasittikul et al, 2010), respectively. Characterization of the sugar moieties from the mixture of quercetin 3-β-galactopyranoside (1) and quercetin 3-β-glucopyranoside (2) was performed according Cota et al 2008b.…”

Section: Resultsmentioning

confidence: 82%

Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis

Cota¹,

Siqueira²,

Oliveira³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Many phenolic compounds such as xanthones, quinones and coumarins have been isolated from Kielmeyera species; however the presence of flavonoids have been showed in other genera in the Calophylleae tribe as Caraipa, Mesua and Calophyllum. Six known glycosidic flavonoids: quercetin 3-β-O-galactopyranoside (1), quercetin 3-β-O-glucopyranoside (2), quercetin 3-O-α-rhamnoside (3), luteolin 6-C-β-glucopyranoside (4), isovitexin (5), kaempferol 3-O-α-rhamnoside (6) and one triterpene, lupenone (7) were isolated, for the first time, from organic crude extract of Kielmeyera variabilis Mart. & Zucc., Calophyllaceae, leaves. The crude organic extract from K. variabilis leaves exhibited 95% of leishmanidal activity at 20 µg/mL on amastigote-like form of Leishmania (Leishmania) amazonensis in vitro model and only compound 3 showed 40-45% of growth inhibition at concentration ranging from 0.78 to 20 µg/mL. In addition, quercetin 3-O-α-rhamnoside (quercitrin) was found to be the major metabolite. Our results and previous reports suggest that synergistic effects of flavonoid glycosides are the cause of significant leishmanidal activity of the crude organic extract from K. variabilis leaves.

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“…Chromatography indicated that it was pure and led to its identification as compound 6 (324 mg). Thus, on the basis of nuclear magnetic resonance (NMR) 1 H and 13 C NMR data analysis, the structures of compounds 1-6 were identified as protocatechuic acid, 19 methyl gallate, 20 isoquercitrin, 21 isovitexin, 22,23 rutin, 21 and corilagin, 24 respectively (Fig. 1).…”

Section: Isolation and Identification Of Compounds From Agfmentioning

confidence: 99%

Alchornea glandulosaEthyl Acetate Fraction Exhibits Antiangiogenic Activity: Preliminary Findings fromIn VitroAssays Using Human Umbilical Vein Endothelial Cells

Lopes

Rocha

Pirraco

et al. 2011

Journal of Medicinal Food

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Alchornea glandulosa has traditionally been used in Brazilian folk medicine for the treatment of immuneinflammatory diseases and as an antiulcer agent to heal gastric ulcer and gastritis. Angiogenesis is a complex multistep process that consists of proliferation, migration, and anastomosis of endothelial cells and has a major role in the development of pathologic conditions, such as inflammatory diseases. To investigate a possible link between the anti-inflammatory activities and antiangiogenic effects of A. glandulosa ethyl acetate fraction (AGF), this study examined which features of the angiogenic process could be disturbed by this fraction. The antiangiogenic activity of AGF was determined in vitro by using human umbilical vein endothelial cells (HUVEC), and cell viability, proliferation, apoptosis, invasion, and capillary-like structures formation were addressed. To elucidate the mechanism of action, nuclear factor jB (NFjB), a transcription factor implicated in these processes, was also evaluated in HUVEC incubated with AGF. A significant decrease in proliferation, a relevant increase in apoptosis, and a strong reduction in invasion capacity (as assessed by bromodeoxyuridine, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling, and double-chamber assays, respectively) were observed. AGF also led to a drastic reduction in the number of capillary-like structures formed when HUVEC were cultured on growth factor-reduced Matrigel-coated plates. In addition, incubation of HUVEC with AGF resulted in reduced NFjB activity. These findings emphasize the antiangiogenic potential of AGF and support its therapeutic use for disorders that involve excessive angiogenesis, such as chronic inflammation and tumor growth.

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Flavonoid glycosides in the shoot system of Okinawa Taumu (Colocasia esculenta S.)

Cited by 47 publications

References 19 publications

Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis

Alchornea glandulosaEthyl Acetate Fraction Exhibits Antiangiogenic Activity: Preliminary Findings fromIn VitroAssays Using Human Umbilical Vein Endothelial Cells

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