Flavonoid glycosides of Alchemilla vulgaris L.

D'Agostino, Mario; Dini, Irene; Ramundo, Eliseo; Senatore, Felice

doi:10.1002/(sici)1099-1573(1998)12:1+<s162::aid-ptr284>3.0.co;2-p

Cited by 24 publications

(20 citation statements)

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“…In another study by the same authors, hydroglycerinated extract of A. vulgaris was shown to enhance myofibroblast and epithelial cell growth in both in vivo and in vitro models (Shrivastava et al, 2007). According to the phytochemical analysis quercetin glycosides were isolated from A. vulgaris (D'Agostino et al, 1998), which reveals a similar phytochemical profile with the two Alchemilla species, A. mollis and A. persica, used as the plant materials of the present research. Therefore, it could be concluded that flavonoid type compounds could also be responsible from the activity of these both species.…”

Section: Discussionsupporting

confidence: 59%

Effects of Alchemilla mollis and Alchemilla persica on the wound healing process

Öz

İlhan

Özbilgin

et al. 2016

Bangladesh J Pharmacol

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Alchemilla mollis, is used in traditional medicine for the treatment of wounds and excessive menstruation. Aqueous methanol extracts of A. mollis and A. persica were evaluated for wound healing acivity by using linear incision and circular excision wound models along with hydroxyproline estimation and histopathological analysis. Anti-inflammatory effect was determined according to Whittle method. The extracts prepared from the aerial parts of A. mollis and A. persica exerted significant wound healing activity with the tensile strength values of 39.3% and 33.3%, respectively, and with the contraction values of 51.4% and 43.5%, respectively. Hydroxyproline estimation and histopathological analysis also confirmed the results. The extracts of A. mollis and A. persica showed significant anti-inflammatory activity with the values of 30.6% and 26.6% respectively. These results showed that A. mollis and A. persica possess significant wound healing and anti-inflammatory activities.Video Clip<a href="https://youtube.com/v/k2Hz7f1e4SI">Circular excision wound model</a>: 2 min

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Section: Discussionsupporting

confidence: 59%

Effects of Alchemilla mollis and Alchemilla persica on the wound healing process

Öz

İlhan

Özbilgin

et al. 2016

Bangladesh J Pharmacol

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“…Flavonoids, which are regarded as the major ingredient of AV, have multiple biological influences, including antidiarrhoeal, antiarthritic, diuretic, depurative, and intestinal antiseptic effects, and improve menopausal distortions (Kahkonen et al, 1999;Galati & O'Brien, 2004;Spiridonov et al, 2005;Nair et al, 2006). These beneficial effects of flavonoids (9.8 mg/g dried whole plant) are attributed mainly to the activation of antioxidant enzymes (D'Agostino et al, 1998;Oktyabrskay et al, 2009), scavenging of free radicals (Hanasaki et al, 1994) and chelation of metal ions (Afanas'ev et al, 1989;Rice-Evans et al, 1997). Although there have been many studies on the use of AV in the field of biological and metabolic disturbances, no studies have been found on the effects of AV on the laying performance and egg quality of quails that have been exposed to high environmental temperatures.…”

Section: Introductionmentioning

confidence: 99%

Alchemilla vulgaris effects on egg production and quality expressed by heatstressed quail during the late laying period

2019

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Potential for mitigating effects of heat stress through dietary Alchemilla vulgaris (AV) supplementation during the late laying period of Japanese quail (Coturnix coturnix japonica) were investigated. A 2 x 3 factorial arrangement of environmental temperature (ET) regimes and levels of dietary supplementation with AV (0%, 1%, and 3%) was used in a 75-day experiment. Twenty-five quail were randomly assigned to each treatment with five replicate cages of five birds. The birds were housed in temperature-controlled rooms at 22 ± 2 °C for 24 h/day (TN) or 34 ± 2 °C between 09h00 and 17h00 followed by 22 ± 2 °C for 16 h/day (HS). The interaction of ET and supplement regimes was rarely significant. In HS quail supplemented with 1% AV, egg production was reduced and FCR was increased compared with the other treatments. Dietary AV was found to reduce egg production in TN conditions, but 3% AV supplementation in the HS group prevented decreased egg production and improved FCR. Various indicators of egg quality were significantly affected by supplementation with AV at certain times during the experiment. Most effects of HS on egg quality were manifest in the first 15 days of ET regimes. Although HS significantly decreased eggshell weight until 31-45 days, AV supplementation improved it on the 45th day and then maintained it through the end of the experiment. Thus, AV may mitigate some effects of HS by partially preventing decreased egg production and increased FCR during the late laying period of Japanese quail.

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“…xanthochlora [17,18] and A. vulgaris [19], while gossypetin glycosides were detected for the first time in the genus Alchemilla. These differences in the chemical composition of the investigated species could be of chemotaxonomic importance.…”

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confidence: 99%

Flavonoid Constituents and Free Radical Scavenging Activity of Alchemilla mollis

Трендафилова

Todorova

Nikolova

et al. 2011

Natural Product Communications

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Antioxidant capacity of the methanolic extract of Alchemilla mollis was measured by its ability to scavenge the DPPH radical. The EtOAc fraction obtained after partition of the total extract was found to be the most active radical scavenger (IC 50 9.8 ± 1.8 μg/mL) and was subjected to fractionation by Sephadex LH-20 CC. Further purification by RP-18 CC led to the isolation of eight flavonoid glycosides: cisand trans-tiliroside (1 and 2), rhodiolgin (3), hyperoside (4), isoquercitrin (5), miquelianin (6), sinocrassoside D 2 (7), and gossypetin-3-O--D-galactopyranosyl-7-O-α-L-rhamnopyranoside (8). It was found that 8 is a new compound and its antioxidant activity is also reported. Identification of the isolated compounds was carried out by spectroscopic and spectrometric analysis (1D and 2D NMR, UV and MS).

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Flavonoid glycosides of Alchemilla vulgaris L.

Cited by 24 publications

References 0 publications

Effects of <i>Alchemilla mollis</i> and <i>Alchemilla persica</i> on the wound healing process

Effects of <i>Alchemilla mollis</i> and <i>Alchemilla persica</i> on the wound healing process

Alchemilla vulgaris effects on egg production and quality expressed by heatstressed quail during the late laying period

Flavonoid Constituents and Free Radical Scavenging Activity of Alchemilla mollis

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