Flavonoid intakes inversely associate with COPD in smokers

Bondonno, Nicola P.; Parmenter, Benjamin H.; Dalgaard, Frederik; Murray, Kevin; Rasmussen, Daniel Bech; Kyrø, Cecilie; Cassidy, Aedín; Bondonno, Catherine P.; Lewis, Joshua R.; Gislason, Gunnar; Scalbert, Augustin; Tjønneland, Anne; Overvad, Kim; Olsen, Anja; Hodgson, Jonathan M.

doi:10.1183/13993003.02604-2021

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…The earliest literature on the relationship between diet and COPD focused on individual nutrients and selected foods. For example, some studies have investigated the relationship between nutrients (such as vitamin C, vitamin E, omega-3 fatty acids, and flavonoids) and COPD and obtained positive results ( 47 – 50 ). Other studies have shown that intake of fruits and vegetables can reduce the incidence of COPD and improve lung function ( 14 , 51 , 52 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of adherence to the DASH diet and the Mediterranean diet with chronic obstructive pulmonary disease among US adults

Wen

Gu²,

Wang³

et al. 2023

Front. Nutr.

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BackgroundThe Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean diet are associated with reduced cardiovascular, tumor, and diabetes risk, but the effect on chronic obstructive pulmonary disease (COPD) is uncertain.ObjectiveTo investigate the association of the DASH diet and the Mediterranean diet with the risk of COPD in American adults.MethodsThis cross-sectional study included 28,605 participants from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 survey cycle who had complete dietary and other questionnaire data. The scores of healthy eating patterns (the DASH diet and the Mediterranean diet) were derived from a 24-h dietary recall interview [individual food and total nutrient data from NHANES and food pattern equivalents data from the United States Department of Agriculture (USDA)]. The primary outcome was the prevalence of COPD. COPD was defined based on participants self-reported whether or not a doctor or health professional had diagnosed chronic bronchitis or emphysema. Secondary outcomes were lung function and respiratory symptoms. All analyses were adjusted for demographics and standard COPD risk factors (primary tobacco exposure, secondhand smoke exposure, and asthma).ResultsThis study included 2,488 COPD participants and 25,607 non-COPD participants. We found that a higher DASH diet score was associated with a lower risk of COPD [odds ratio (OR): 0.83; 95% confidence interval (CI): 0.71–0.97; P = 0.021]. This association persisted in several subgroups [men (OR: 0.73; 95% CI: 0.58–0.93; P = 0.010), relatively young (OR: 0.74; 95% CI: 0.55–1.01; P = 0.050), and smoker (OR: 0.82; 95% CI: 0.67–0.99; P = 0.038)]. In contrast, the Mediterranean diet score was not significantly associated with COPD prevalence in this large cross-sectional analysis representative of the US adult population (OR: 1.03; 95% CI: 0.88–1.20; P = 0.697). In addition, we found a correlation between DASH diet adherence and lung function [β: −0.01; 95% CI: −0.01–0.00; P = 0.003 (FEV1: FVC)] or respiratory symptoms [OR: 0.80; 95% CI: 0.73–0.89; P < 0.001 (dyspnea); OR: 0.80; 95% CI: 0.70–0.91; P = 0.002 (cough); OR: 0.86; 95% CI: 0.74–0.99; P = 0.042 (expectoration)], especially in non-COPD populations.ConclusionA higher DASH diet score was associated with improved COPD prevalence, lung function and respiratory symptoms. This new finding supports the importance of diet in the pathogenesis of COPD and expands the scope of the association of the DASH diet score with major chronic diseases.

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Section: Discussionmentioning

confidence: 99%

Associations of adherence to the DASH diet and the Mediterranean diet with chronic obstructive pulmonary disease among US adults

Wen

Gu²,

Wang³

et al. 2023

Front. Nutr.

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“…This is of note as in our previous studies of flavonoid intake and disease risk in the Danish Diet Cancer and Health cohort, those diseases for which smoking is a more influential risk factor, have all been more strongly associated with flavonoid intake. This extends to peripheral artery disease [15], abdominal aortic aneurysm [15], and chronic obstructive pulmonary disease [39]. There are several intriguing explanations for these observations.…”

Section: Discussionmentioning

confidence: 93%

Intake of dietary flavonoids and incidence of ischemic heart disease in the Danish Diet, Cancer, and Health cohort

et al. 2022

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Background/Objectives Few studies have investigated the association between dietary flavonoid intake, including all major subclasses, and the long-term risk of ischemic heart disease (IHD). We examined whether dietary flavonoid intake associated with IHD incidence, assessing the possible modifying role of sex and smoking, in participants from the Danish Diet, Cancer, and Health study. Subjects/Methods In a cohort study design, 54,496 adults (46.8% male), aged 50–64 years, without a history of IHD, were followed for up to 23 years. Habitual dietary flavonoid intake was estimated from food frequency questionnaires using Phenol-Explorer. Incident cases of IHD were identified within Danish nationwide health registries. Restricted cubic splines in Cox proportional hazards models were used to examine associations between flavonoid intake and IHD risk. Results During follow-up, 5560 IHD events were recorded. No overall association was seen between total flavonoid intake, nor any subclass, and IHD, following adjustment for demographics, lifestyle, and dietary confounders. Stratified by sex and smoking status, higher intakes of specific subclasses associated with lower IHD risk among ever-smokers [Q5 vs. Q1 flavonols HR (95% CI): 0.90 (0.82, 0.99); flavanol oligo+polymers: 0.88 (0.80, 0.97)], but not among never-smokers, nor either sex specifically. Conclusions While we did not find clear evidence that higher habitual dietary flavonoid intake was associated with lower IHD risk, these results do not exclude the possibility that certain subclasses may have a protective role in prevention of IHD among population sub-groups; this was evident among smokers, who are at a higher risk of atherosclerosis.

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“…Considering that COPD is characterized by a pro-oxidative [ 2 ], pro-inflammatory state [ 154 ] and, consequently, a reduced antioxidant capacity [ 155 ], there has been interest in exploring the potential therapeutic benefit of polyphenols on the pathogenesis and disease course of COPD. For example, polyphenol intake has been shown to reduce the risk of developing COPD [ 156 , 157 ] and, once the disease is developed, may reduce lung inflammation [ 158 ] and markers of cardiovascular disease risk [ 159 ]. Indeed, six-month supplementation with quercetin—a plant flavonoid—significantly reduced proinflammatory biomarkers in the bronchoalveolar lavage of patients with COPD (GOLD stage II–III) [ 158 ], while six-week supplementation with resveratrol—a stilbenoid polyphenol [ 160 ]—resulted in improvements in arterial stiffness, myocardial perfusion, and distance walked in patients with COPD (GOLD stage II–IV) [ 159 ].…”

Section: Othermentioning

confidence: 99%

“…Preliminary evidence supports polyphenols’ role in reducing the risk of COPD development [ 156 , 157 ], as well as health benefits once the disease is established [ 158 , 159 ]. However, as the literature stands, there is not enough evidence to recommend the dosage or type of polyphenol intake for patients with COPD, nor for the prevention of this disease, due to the heterogeneity of these studies and minimal information [ 157 , 159 , 161 ]. Notwithstanding, a diet rich in polyphenols may be beneficial to those at risk of developing COPD due to their potential anti-inflammatory effects [ 158 ].…”

Section: Othermentioning

confidence: 99%

The Role of Nutrition in the Development and Management of Chronic Obstructive Pulmonary Disease

Heefner,

Simovic,

Mize

et al. 2024

Nutrients

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Chronic obstructive pulmonary disease (COPD) is a prevalent lung condition associated with significant morbidity and mortality. The management of COPD classically involves pulmonary rehabilitation, bronchodilators, and corticosteroids. An aspect of COPD management that is currently lacking in the literature is nutritional management, despite the prevalence of inadequate nutritional status in patients with COPD. In addition, certain nutritional imbalances have been reported to increase the risk of COPD development. This review summarizes the current literature on the role diet and nutrients may play in the risk and management of COPD development.

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Flavonoid intakes inversely associate with COPD in smokers

Cited by 14 publications

References 34 publications

Associations of adherence to the DASH diet and the Mediterranean diet with chronic obstructive pulmonary disease among US adults

Associations of adherence to the DASH diet and the Mediterranean diet with chronic obstructive pulmonary disease among US adults

Intake of dietary flavonoids and incidence of ischemic heart disease in the Danish Diet, Cancer, and Health cohort

The Role of Nutrition in the Development and Management of Chronic Obstructive Pulmonary Disease

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