Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA

Johnston, Graham A.R.

doi:10.1016/j.neuint.2015.07.013

Cited by 77 publications

(55 citation statements)

References 72 publications

(95 reference statements)

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“…Furthermore, it has positive therapeutic effects against breast cancer, colon cancer, and melanoma (5–7); ii) it exerts spasmolytic, antihypertensive, and vasodilator effects (8,9); iii) it exerts anti-inflammatory effects by inhibiting the high expression of nitric oxide (NO) synthase by macrophages (10); iv) it exerts sedative and anxiolytic effects by enhancing γ-aminobutyric acid neurotransmission (11,12); and v) it exerts inhibitory effects against multiple gram-negative bacteria (13,14). …”

Section: Introductionmentioning

confidence: 99%

Apigenin in the regulation of cholesterol metabolism and protection of blood vessels

Zhang

Song

et al. 2017

Experimental and Therapeutic Medicine

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Hyperlipidemia is a major independent risk factor for atherosclerosis. Seeking natural compounds in medicinal plants capable of reducing blood fat and studying their mechanisms of action has been the focus of research in recent years. The aim of the present study was to analyze the mechanisms of apigenin in regulating cholesterol metabolism and protecting blood vessels, and to provide a theoretical basis for the clinical application of apigenin. The mouse model of hyperlipidemia was established to verify the efficacy of apigenin in improving hyperlipidemia and to observe the mechanism of action of apigenin in reducing cholesterol content. In vitro cell experiments were conducted to evaluate the role of apigenin in mediating reverse cholesterol transport. Additionally, H2O2-injured human umbilical venous endothelial cells (EA.hy926 cells) were used for further study on the roles of apigenin in resisting oxidization and protecting vascular endothelial cells. Apigenin significantly regulated blood fat, reduced animal weight, and reduced total cholesterol (P=0.024), triglyceride (P=0.031) and low-density lipoprotein cholesterol (P=0.014) in the serum of the high-fat diet mice. Apigenin improved the blood lipid metabolism of the hyper-lipidemia model mice. Body weight and serum cholesterol content increased abnormally (P=0.003) as a consequence of high-fat diet. Apigenin increased the activity of superoxide dismutase in EA.hy926 cells (P=0.043) and increased the amount of nitric oxide secreted by the cells (P=0.038). Apigenin also inhibited the proliferation of vascular smooth muscle cells in a dose-dependent manner (P=0.036). In conclusion, apigenin can regulate cholesterol metabolism in vivo and plays a role in reducing the level of blood fat by promoting cholesterol absorption and conversion, and accelerating reverse cholesterol transport. Apigenin also has a role in resisting oxidization and protecting blood vessels.

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Section: Introductionmentioning

confidence: 99%

Apigenin in the regulation of cholesterol metabolism and protection of blood vessels

Zhang

Song

et al. 2017

Experimental and Therapeutic Medicine

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“…Except when consumed as dietary supplements, lavonoids are generally consumed as a mixture of diferent lavonoids from one or more foodstufs [59]. The efects of mixtures of lavonoids and other modulators on GABA A receptors need to be more thoroughly investigated.…”

Section: Synergism Between Lavonoidsmentioning

confidence: 99%

Flavonoid Actions on Receptors for the Inhibitory Neurotransmitter GABA

Hinton¹,

Hanrahan²,

Johnston³

2017

Flavonoids - From Biosynthesis to Human Health

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Flavonoids, both naturally occurring and synthetic, are known to have multiple efects on the activation of ionotropic receptors for γ-aminobutyric acid (GABA), the major inhibitory neurotransmiter in our brains. They can act as positive or negative allosteric modulators, enhancing or reducing the efect of GABA. They can elicit a direct activation of the receptors. They can also act to modulate the action of other modulators. This ability to inluence function via their actions on GABA receptors permits a range of efects of lavonoids, including relief of anxiety, anticonvulsant, analgesic and sedative actions.

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“…GABA gibi birçok nörotransmitter hafıza ve bellek sistemlerine katılmaktadır. luteolin GABA reseptörlerini module ettiği için yapılan deneyde hafıza ve bellekte artma olduğu görülmüştür (12).…”

Section: Flavonoi̇dlerunclassified

Di̇yabet Ve Hi̇pertansi̇yonda Kullanilan Takvi̇ye Edi̇ci̇ Gidalar

Elçioğlu¹,

Kemerci²

2016

Marmara Pharmaceutical Journal

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Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA

Cited by 77 publications

References 72 publications

Apigenin in the regulation of cholesterol metabolism and protection of blood vessels

Apigenin in the regulation of cholesterol metabolism and protection of blood vessels

Flavonoid Actions on Receptors for the Inhibitory Neurotransmitter GABA

Di̇yabet Ve Hi̇pertansi̇yonda Kullanilan Takvi̇ye Edi̇ci̇ Gidalar

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