Flavonoid oligomers from Chinese dragon’s blood, the red resins of Dracaena cochinchinensis

Zheng, Qing‐An; Xu, Min; Yang, Chong‐Ren; Wang, Dong; Li, Haizhou; Zhu, Hongtao; Zhang, Yingjun

doi:10.1007/s13659-012-0020-5

Cited by 21 publications

(9 citation statements)

References 28 publications

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“…The NMR of 2 were very similar to the known compound manglieside D [13]. By comparison of the NMR data in literatures, the same structure segments of a 1,3,5-trisubstituted aromatic ring, a disubstituted E -configuration double bond and a sugar unit were confirmed [18, 19]. The major difference was that compound 2 possessed a different 1′,3′,4′, 5′-tetrasubstituted aromatic ring, in which a methoxy group at C-3 ′ of manglieside D was replaced by a hydroxy group and this could be confirmed by its molecular formula and different proton signals at δ H 6.81 (1H, d, J = 1.8 Hz, H-2′), δ H 6.83 (1H, d, J = 1.8 Hz, H-6′).…”

Section: Resultssupporting

confidence: 53%

Chemical Constituents from the Stems of Ecdysanthera rosea

Song

Lunga

Qin

et al. 2014

Nat. Prod. Bioprospect.

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One new eudesmane sesquiterpenoid (1) named ecdysantherol A and two new benzene derivatives ecdysantherols B (2) and C (3), together with five known benzene derivatives (4–8) were isolated from the stems of Ecdysanthera rosea. The structures of the new compounds were elucidated by extensive spectroscopic methods and X-ray diffraction. The known compounds were identified by the comparison of their spectroscopic data with reported literature data. Compound 1 showed moderate antibacterial activity against the Providensia smartii with MIC value of 12.5 μg/mL.Electronic supplementary materialThe online version of this article (doi:10.1007/s13659-014-0041-3) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 53%

Chemical Constituents from the Stems of Ecdysanthera rosea

Song

Lunga

Qin

et al. 2014

Nat. Prod. Bioprospect.

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“…The results of the analyses of chemical constituents indicate that the main components of dragon’s blood are flavonoids7891011. The limited transcriptomic data and genomic data hinder the study of the molecular mechanisms of flavonoids accumulation in D. cambodiana.…”

Section: Discussionmentioning

confidence: 99%

“…However, the formation mechanism of dragon’s blood is still unknown. Phytochemical studies of dragon’s blood revealed that flavonoids are the main chemical constituents, while terpenes, steroids, saponins and phenols have also been identified as constituents7891011. Owing to a lack of Dracaena plants genomic information, the molecular basis of specific flavonoids biosynthesis and the regulation of formation in Dracaena plants remain unknown.…”

mentioning

confidence: 99%

De Novo transcriptome characterization of Dracaena cambodiana and analysis of genes involved in flavonoid accumulation during formation of dragon’s blood

Zhu

Cao

Dai

et al. 2016

Sci Rep

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Dragon’s blood is a red resin mainly extracted from Dracaena plants, and has been widely used as a traditional medicine in East and Southeast Asia. The major components of dragon’s blood are flavonoids. Owing to a lack of Dracaena plants genomic information, the flavonoids biosynthesis and regulation in Dracaena plants remain unknown. In this study, three cDNA libraries were constructed from the stems of D. cambodiana after injecting the inducer. Approximately 266.57 million raw sequencing reads were de novo assembled into 198,204 unigenes, of which 34,873 unique sequences were annotated in public protein databases. Many candidate genes involved in flavonoid accumulation were identified. Differential expression analysis identified 20 genes involved in flavonoid biosynthesis, 27 unigenes involved in flavonoid modification and 68 genes involved in flavonoid transport that were up-regulated in the stems of D. cambodiana after injecting the inducer, consistent with the accumulation of flavonoids. Furthermore, we have revealed the differential expression of transcripts encoding for transcription factors (MYB, bHLH and WD40) involved in flavonoid metabolism. These de novo transcriptome data sets provide insights on pathways and molecular regulation of flavonoid biosynthesis and transport, and improve our understanding of molecular mechanisms of dragon’s blood formation in D. cambodiana.

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“…Flavonoid dimers and trimers (Figures 12 and 13): cochinchinenenes A-D (structures 60,63-65 in Figure 11) [44,47,53], cochinchinenenes E (66) and F (61) [43], cochinchinenenes G (67) and H (62) [44], "cochinchinenene G" (68) [42], (2R)-8-methylsocotrin-4 -ol (69) [47], cochinchinenin [44], cochinchinenin B (75) [47] 12 and 13), cinnabarone (26) [39], dracaenin A (79) [42,54], socotrin-4 -ol (28) and homoisosocotrin-4 -ol (29) [40], cochinchinenins I-M (structures 78,81,71,72,73 in Figure 12), (2RγS)-3 -methoxy-8-methylsocotrin-4 -ol, (2SγR)-3 -methoxy-8-methyls ocotrin-4 -ol, (2RγR)-8-methylsocotrin-4 -ol, (2RγS)-8-methyl-socotrin-4 -ol [55][56][57], compound 74 [53], and biflavocochins A-G (structures 82-88 in Figure 13) [53].…”

Section: Dracaena Cochinchinensis (Lour) Sc Chenmentioning

confidence: 99%

Flavonoids and Stilbenoids of the Genera Dracaena and Sansevieria: Structures and Bioactivities

Thu¹,

Myo²,

Aung

et al. 2020

Molecules

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The genera Dracaena and Sansevieria (Asparagaceae, Nolinoideae) are still poorly resolved phylogenetically. Plants of these genera are commonly distributed in Africa, China, Southeast Asia, and America. Most of them are cultivated for ornamental and medicinal purposes and are used in various traditional medicines due to the wide range of ethnopharmacological properties. Extensive in vivo and in vitro tests have been carried out to prove the ethnopharmacological claims and other bioactivities. These investigations have been accompanied by the isolation and identification of hundreds of phytochemical constituents. The most characteristic metabolites are steroids, flavonoids, stilbenes, and saponins; many of them exhibit potent analgesic, anti-inflammatory, antimicrobial, antioxidant, antiproliferative, and cytotoxic activities. This review highlights the structures and bioactivities of flavonoids and stilbenoids isolated from Dracaena and Sansevieria.

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Flavonoid oligomers from Chinese dragon’s blood, the red resins of Dracaena cochinchinensis

Cited by 21 publications

References 28 publications

Chemical Constituents from the Stems of Ecdysanthera rosea

Chemical Constituents from the Stems of Ecdysanthera rosea

De Novo transcriptome characterization of Dracaena cambodiana and analysis of genes involved in flavonoid accumulation during formation of dragon’s blood

Flavonoids and Stilbenoids of the Genera Dracaena and Sansevieria: Structures and Bioactivities

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