Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/��-Catenin Signaling Activation in 3-Dimensional-Spheroid Cultured Human Dermal Papilla Cells

Cheon, Hye In; Bae, Seunghee; Ahn, Kyu Joong

doi:10.4014/jmb.1810.10050

Cited by 26 publications

(17 citation statements)

References 33 publications

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“…Co-treatment with an Akt inhibitor abrogated silibinin-induced Akt phosphorylation and TCF/Lef activity. In addition, silibinin increased the mRNA levels of DPC markers ALP, FGF7, and BMP2, suggesting the potential of silibinin in promoting hair growth [ 70 ].…”

Section: Progress In Developing Therapy For Hair Loss By Targetingmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

140

105

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Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

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Section: Progress In Developing Therapy For Hair Loss By Targetingmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

140

105

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“…Silibinin, a secondary metabolite from Silybum marianum, is an effective antioxidant that prevents various cutaneous problems. Recently, silibinin treatment was reported to enhance spheroid formation of FDPC through the activation of AKT and Wnt/β-catenin-signaling pathways [41]. Another important flavonoid widely used as traditional Chinese herbal medicine is BC.…”

Section: Natural Alternative Interventionsmentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…To date, a large number of therapeutic candidates associated with hair induction and proliferation as well as hair growth have been developed [35,36]. In this study, we evaluated CJPE as a potential therapeutic agent regulating scalp improvement.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract

Cho

Kim²,

Paek³

et al. 2021

FEBS Open Bio

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Camellia japonica L. is a flowering tree with several medicinal and cosmetic applications. Here, we investigated the efficacy of C. japonica placenta extract (CJPE) as a potential therapeutic agent for promotion of hair growth and scalp health by using various in vitro and in vivo assays. Moreover, we performed transcriptome analysis to examine the relative expression of human follicle dermal papilla cells (HFDPC) in response to CJPE by RNA‐sequencing (RNA‐seq). In vitro assays revealed upregulation of the expression of hair growth marker genes in HFDPC after CJPE treatment. Moreover, in vivo clinical tests with 42 adult female participants showed that a solution containing 0.5% CJPE increased the moisture content of the scalp and decreased the scalp's sebum content, dead scalp keratin, and erythema. Furthermore, RNA‐seq analysis revealed key genes in HFDPC which are associated with CJPE. Interestingly, genes associated with lipid metabolism and cholesterol efflux were upregulated. Genes upregulated by CJPE are associated with several hormones, including parathyroid, adrenocorticotropic hormone, α‐melanocyte‐stimulating hormone (alpha‐MSH), and norepinephrine, which are involved in hair follicle biology. Furthermore, some upregulated genes are associated with the regulation of axon guidance. In contrast, many genes downregulated by CJPE are associated with structural components of the cytoskeleton. In addition, CJPE suppressed genes associated with muscle structure and development. Taken together, this study provides extensive evidence that CJPE may have potential as a therapeutic agent for scalp treatment and hair growth promotion.

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Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/��-Catenin Signaling Activation in 3-Dimensional-Spheroid Cultured Human Dermal Papilla Cells

Cited by 26 publications

References 33 publications

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract

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