Flavonoid-triazolyl hybrids as potential anti-hepatitis C virus agents: Synthesis and biological evaluation

Zhang, Han; Zheng, Xin; Li, Jichong; Liu, Qingbo; Huang, Xiao‐Xiao; Ding, Huaiwei; Suzuki, Ritsuro; Muramatsu, Masamichi; Song, Shao‐Jiang

doi:10.1016/j.ejmech.2021.113395

Cited by 7 publications

(2 citation statements)

References 41 publications

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“…Zhang et al (2021) reported the synthesis of a series of flavanone derivatives ( 58a – 58s , Figure 21 ) and their antiviral activity against hepatitis C virus (HCV) [ 98 ]. After the synthesis of intermediate O -propargylated flavanone, the Click Chemistry step was performed with different azides, giving compounds 58a – 58s with 56–80% yield.…”

Section: 123-triazole-linked Flavonoid Hybrids With Antimicrobial Activitymentioning

confidence: 99%

“…Moreover, these compounds inhibited the HCV production in a dose-dependent manner, being the activity comparable with the positive control at 30 µM. Complementary studies showed that 58m and 58r inhibited the entry of HCV in the cell surface by 34% and 52% at 10 µM, respectively [ 98 ].…”

Section: 123-triazole-linked Flavonoid Hybrids With Antimicrobial Activitymentioning

confidence: 99%

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Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

et al. 2021

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As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed. Since the triazole ring has been associated with several biological activities and metabolic stability, hybridization with a 1,2,3-triazole ring has been increasingly reported over the last years. The feasible synthesis through copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) has allowed the accomplishment of several hybrids. Since 2017, almost 700 flavonoid hybrids conjugated with 1,2,3-triazole, including chalcones, flavones, flavanones and flavonols, among others, with antitumor, antimicrobial, antidiabetic, neuroprotective, anti-inflammatory, antioxidant, and antifouling activity have been reported. This review compiles the biological activities recently described for these hybrids, highlighting the mechanism of action and structure–activity relationship (SAR) studies.

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Section: 123-triazole-linked Flavonoid Hybrids With Antimicrobial Activitymentioning

confidence: 99%

Section: 123-triazole-linked Flavonoid Hybrids With Antimicrobial Activitymentioning

confidence: 99%

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

et al. 2021

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Pseudotyped Virus for Flaviviridae

Zhang

Wang

Ming

et al. 2023

Advances in Experimental Medicine and Biology

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Synthetic transformations of sesquiterpene lactones. Controllable synthesis of 11,13-dihydroisoalantolactone azides and 13-(1,2,3-triazolyl)eudesmanolides based on sesquiterpene lactones

Patrushev

Рыбалова

Шульц

2021

Chem Heterocycl Comp

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Flavonoid-triazolyl hybrids as potential anti-hepatitis C virus agents: Synthesis and biological evaluation

Cited by 7 publications

References 41 publications

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

Pseudotyped Virus for Flaviviridae

Synthetic transformations of sesquiterpene lactones. Controllable synthesis of 11,13-dihydroisoalantolactone azides and 13-(1,2,3-triazolyl)eudesmanolides based on sesquiterpene lactones

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