Flavonoids: A treasure house of prospective pharmacological potentials

Hasnat, Hasin; Shompa, Suriya Akter; Islam, Md. Mirazul; Alam, Safaet; Richi, Fahmida Tasnim; Emon, Nazim Uddin; Ashrafi, Sania; Ahmed, Nazim Uddin; Chowdhury, Md. Nafees Rahman; Fatema, Nour; Hossain, Md. Sakhawat; Ghosh, Avoy; Ahmed, Firoj

doi:10.1016/j.heliyon.2024.e27533

Cited by 28 publications

(1 citation statement)

References 212 publications

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“…Yang et al identified about 102 compounds from the fruiting bodies of H. erinaceus , including organic acids, nucleotides and analogues, amino acids, carbohydrates and derivatives, flavonoids, unsaturated fatty acids, terpenoids, phenolic acids, phenylpropanoid, and steroids [ 29 ]. The authors further suggested that flavonoids which were qualitatively detected in the analysis (luteolin, apigenin, diosmetin, hispidulin, and acacetin) could function as active components in H. erinaceus based on previous studies which demonstrated flavonoids’ pharmacological functions which include neuroprotection, improved learning and memory, anti-inflammatory, and more [ 30 , 31 , 32 ]. Of note, in a study by He et al, two isoflavones were identified and isolated in H. erinaceus mycelium: genistein and daidzein, comprising 15% and 12% of the ethanolic extract, respectively [ 33 ].…”

Section: Identification Of Novel Bioactive Compounds In Her...mentioning

confidence: 99%

Unveiling the Chemical Composition and Biofunctionality of Hericium spp. Fungi: A Comprehensive Overview

Kostanda,

Musa,

Pereman

2024

IJMS

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In recent years, research on mushrooms belonging to the Hericium genus has attracted considerable attention due to their unique appearance and well-known medicinal properties. These mushrooms are abundant in bioactive chemicals like polysaccharides, hericenones, erinacines, hericerins, resorcinols, steroids, mono- and diterpenes, and corallocins, alongside essential nutrients. These compounds demonstrate beneficial bioactivities which are related to various physiological systems of the body, including the digestive, immune, and nervous systems. Extensive research has been conducted on the isolation and identification of numerous bioactive chemicals, and both in vitro and in vivo studies have confirmed their antimicrobial, antioxidant, immunomodulatory, antidiabetic, anticholesterolemic, anticancer, and neuroprotective properties. Therefore, this review aims to provide a comprehensive summary of the latest scientific literature on the chemical composition and secondary metabolites profile of Hericium spp. through an introduction to their chemical characteristics, speculated biosynthesis pathways for key chemical families, potential toxicological aspects, and a detailed description of the recent updates regarding the bioactivity of these metabolites.

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Section: Identification Of Novel Bioactive Compounds In Her...mentioning

confidence: 99%

Unveiling the Chemical Composition and Biofunctionality of Hericium spp. Fungi: A Comprehensive Overview

Kostanda,

Musa,

Pereman

2024

IJMS

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Biomimetic Chemical Reactions with Natural Products Using Metalloporphyrins and Salen Complexes as Catalysts: A Brief Review

Sousa,

Confessor,

Da Silva

et al. 2024

Chemistry & Biodiversity

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The cytochrome P450 is a superfamily of hemoproteins mainly present in the liver and are versatile biocatalysts. They participate in the primary metabolism and biosynthesis of various secondary metabolites. Chemical catalysts are utilized to replicate the activities of enzymes. Metalloporphyrins and Salen complexes can contribute to the products’ characterization and elucidate biotransformation processes, which are investigated during pre‐clinical trials. These catalysts also help discover biologically active compounds and get better yields of products of industrial interest. This review aims to investigate which natural product classes are being investigated by biomimetic chemical models and the functionalities applied in the use of these catalysts. A limited number of studies were observed, with terpenes and alkaloids being the most investigated natural product classes. The research also revealed that Metalloporphyrins are still the most popular in the studies, and the identity and yield of the products obtained depend on the reaction system conditions.

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Unveiling the Therapeutic Potentials of Water Hyacinth (Eichhornia crassipes (Mart.) Solms) Flower against Oxidative Stress, Inflammation and Depressive Disorders: GC‐MS/MS, In Vitro, In Vivo and In Silico Approaches

Hasnat,

Riti,

Shompa

et al. 2024

Chemistry & Biodiversity

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Water hyacinth (Eichhornia crassipes (Mart.) Solms) is a highly invasive aquatic weed native to the Amazonia basin, known for its rapid propagation, adaptability and utilization in traditional medicine. The study aims to unveil the therapeutic potential of water hyacinth flowers methanolic extract (EC‐CME) and its four kupchan fractions (EC‐PESF, EC‐DCMSF, EC‐EASF, EC‐ASF) through diversified chemical‐pharmacological approaches. GC‐MS/MS of EC‐CME uncovered a rich tapestry of 72 phytochemical components. In vitro DPPH scavenging assay and total phenolic content determination assay deciphered promising antioxidant assays with remarkably low IC50 values of 0.353 and 0.485 µg/mL, respectively for EC‐ESF and EC‐ASF. Besides, different in vivo tests, including tail emersion, acetic acid‐induced writhing, and thiopental‐induced sleeping test of EC‐CME, yielded a remarkable 8.61 ± 0.29 minutes of tail immersion time compared to the control's 2.05 ± 0.11 minutes at the highest dose (600 mg/kg). The best % inhibition of writhing was recorded as 47.96% accrued in 400 mg/kg dose, indicating robust pain‐relieving properties. The onset and duration of sleep are significantly ameliorated for EC‐CME, unveiling its antidepressant potential. Besides, molecular docking studies along with ADME/T analysis also validated the wet lab findings as well as their safety, efficacy and drug‐likeliness profile.

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Flavonoids: A treasure house of prospective pharmacological potentials

Cited by 28 publications

References 212 publications

Unveiling the Chemical Composition and Biofunctionality of Hericium spp. Fungi: A Comprehensive Overview

Unveiling the Chemical Composition and Biofunctionality of Hericium spp. Fungi: A Comprehensive Overview

Biomimetic Chemical Reactions with Natural Products Using Metalloporphyrins and Salen Complexes as Catalysts: A Brief Review

Unveiling the Therapeutic Potentials of Water Hyacinth (Eichhornia crassipes (Mart.) Solms) Flower against Oxidative Stress, Inflammation and Depressive Disorders: GC‐MS/MS, In Vitro, In Vivo and In Silico Approaches

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