Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts

Sannomiya, Míriam; Fonseca, Vitor B.; Silva, M.A. da; Rocha, Lúcia Regina Machado da; Santos, Lourdes Campaner dos; Hiruma-Lima, Clélia Akiko; Brito, Alba Regina Monteiro Souza; Vilegas, Wagner

doi:10.1016/j.jep.2004.09.053

Cited by 115 publications

(87 citation statements)

References 31 publications

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“…O Brasil concentra cerca de 50% das espécies nas regiões Norte, Nordeste e Central, podendo também ser encontradas na região Sudeste do país, em áreas do cerrado. Essas espécies são conhecidas popularmente no Brasil como "muricis" (murici da várzea, murici da mata, murici-amarelo, dentre outros), sendo diferenciadas pela cor de suas flores e frutos, ou pelo local de ocorrência (Guilhon-Simplicio & Pereira, 2011) e são comumente empregadas na medicina popular (Sannomiya et al, 2005).…”

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Compostos químicos e aspectos botânicos, etnobotânicos e farmacológicos da Byrsonima verbascifolia Rich ex. A. Juss

Saldanha

Soares

2015

Rev. bras. plantas med.

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RESUMO:Byrsonima verbascifolia Rich ex. A. Juss é uma espécie do cerrado brasileiro com uso etnobotânico vasto. O objetivo desse trabalho foi realizar um levantamento bibliográfico de artigos originais e revisões, indexados até agosto de 2014 nas bases de dados Periódicos CAPES, Scielo, Scopus, Web of Science e Medline, nos idiomas português e inglês, utilizando a palavra-chave Byrsonima verbascifolia. Foram contemplados a composição química e os aspectos botânicos, etnobotânicos e farmacológicos. Os estudos presentes na literatura avaliaram as atividades antioxidante, antifúngica, antiviral, antimicrobiana, moluscicida, antimutagênica, mutagênica, teratogênica, imunomodulatória, tóxica e citotóxica de extratos dessa espécie. Apenas um estudo avaliou a atividade da Byrsonima verbascifolia Rich ex. A. Juss in vivo, sendo comprovado que o extrato hidrometanólico das folhas não induz teratogênese, mutagênese ou efeito estimulante ou depressor da resposta imune. Metodologias in vitro predominaram o que demonstra a necessidade de investigação científica empregando testes in vivo para a melhor avaliação das outras atividades biológicas mencionadas. Palavras-chave:Byrsonima verbascifolia, murici, anti-inflamatório, compostos químicos, atividades farmacológicas.ABSTRACT: Chemical compounds and botanical, ethnobotanical and pharmacological aspects of Byrsonima verbascifolia Rich ex. A. Juss. Byrsonima verbascifolia is a species of Brazilian cerrado with extensive ethnobotanical application. The aim of this study was to perform a bibliographic description of original papers and reviews indexed until August 2014 in the databases of the CAPES Digital Library, Scielo, Scopus, Web of Science and Medline, written in Portuguese and English, using the keyword Byrsonima verbascifolia. The chemical and botanical compositions and the ethnobotanical and pharmacological aspects were contemplated. The researches in the reports evaluated the antioxidant, antifungal, antiviral, antimicrobial, molluscicide, antimutagenic, mutagenic, teratogenic, immunomodulatory, toxic and cytotoxic activities of the extracts of this specie. Only one study evaluated the in vivo activity of the Byrsonima verbascifolia Rich ex. A. Juss and proved that the hydromethanolic extract from the leaves does not induce teratogenesis, mutagenesis, stimulant or depressant effect of the immune response. The In vitro methodologies represented the higher number of researches demonstrating the need of scientific investigation using in vivo tests for better assessment of other biological activities mentioned.

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Compostos químicos e aspectos botânicos, etnobotânicos e farmacológicos da Byrsonima verbascifolia Rich ex. A. Juss

Saldanha

Soares

2015

Rev. bras. plantas med.

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“…The phytochemical investigation of the leaves and stems afforded the flavonoids (+)-catechin, (-)-epicatechin, quercitrin and isoquercitrin, which are frequently found in Byrsonima species including B. basiloba, 6,7 B. bucidaefolia, 8 B. crassa, 9,10 B. crassifolia, [11][12][13][14] B. fagifolia, [15][16][17] B. intermedia, 18 B. microphylla, 19,20 and B. verbascifolia; 21,22 the investigation also afforded the tannins 3,5-di-O-galloylquinic acid, 5-O-galloylquinic acid, 5-O-(3-methylgalloyl)-quinic acid, 3,4,5-tri-O-galloylquinic acid and gallic acid, which have been previously described in B. crassa 9,10 and B. fagifolia. [15][16][17] Among the compounds isolated from the stems of B. coccolobifolia, (+)-syringaresinol and trigonostemone are new in the genus Byrsonima.…”

Section: Resultsmentioning

confidence: 83%

“…is a medicinal plant used to treat stomach disorders and as an antidiarrheal. 1,3 Previously, the extracts of the leaves have been shown to have antibacterial and molluscicidal activities and the ability to inhibit arginase, a molecular target of Leishmania amazonensis. [3][4][5] The compounds most commonly isolated from this genus are flavonoids, terpenes, gallic acids and quinic acid derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…1,3 Previously, the extracts of the leaves have been shown to have antibacterial and molluscicidal activities and the ability to inhibit arginase, a molecular target of Leishmania amazonensis. [3][4][5] The compounds most commonly isolated from this genus are flavonoids, terpenes, gallic acids and quinic acid derivatives. 1 Among the constituents, flavonoids (flavanones, bioflavonoids, flavonols and procyanidins), triterpenes (with oleanolic and ursolic skeletons) and modified triterpenoids (steroids) are commonly found in B. basiloba, 6,7 B. bucidaefolia, 8 B. crassa, 9,10 B. crassifolia, [11][12][13][14] B. fagifolia, [15][16][17] B. intermedia, 18 B. microphylla, 19,20 and B. verbascifolia.…”

Section: Introductionmentioning

confidence: 99%

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NEW DEGRADED QUINONE DITERPENOID FROM THE STEMS OF Byrsonima coccolobifolia Kunth. (Malpighiaceae)

et al. 2017

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A chemical investigation of two specimens of Byrsonima coccolobifolia collected in the southeast cerrado and from central Brazil was performed. A new degraded diterpenoid, byrsonimaquinone, was isolated from the stems along with known compounds. This is the first study on the roots of B. coccolobifolia, and several triterpenes, such as α-amyrin, β-amyrin, oleanolic acid, and glochidonol, along with a mixture of stigmasterol, β-sitosterol and campesterol, were identified. These compounds were identified by spectroscopic analysis techniques, including 1D and 2D NMR, GC-MS and high-resolution mass spectrometry.

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“…Estudos químicos dessas espécies revelaram a presença de ácido gálico, ácido galoilquínico, catequinas, galocatequinas, taninos condensados, flavonóis e flavonas SANNOMIYA et al, 2007;SANNOMIYA et al, 2005a;SANNOMIYA et al, 2005b; …”

Section: O Gênero Byrsonima (Malpighiaceae)unclassified

Determinação de enantiômeros em extratos vegetais por cromatografia quiral e dicroísmo circular

Rinaldo¹

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Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts

Cited by 115 publications

References 31 publications

Compostos químicos e aspectos botânicos, etnobotânicos e farmacológicos da Byrsonima verbascifolia Rich ex. A. Juss

Compostos químicos e aspectos botânicos, etnobotânicos e farmacológicos da Byrsonima verbascifolia Rich ex. A. Juss

NEW DEGRADED QUINONE DITERPENOID FROM THE STEMS OF Byrsonima coccolobifolia Kunth. (Malpighiaceae)

Determinação de enantiômeros em extratos vegetais por cromatografia quiral e dicroísmo circular

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