Flavonoids and glaucoma: revisiting therapies from the past

Miléa, Dan; Aung, Tin

doi:10.1007/s00417-015-3167-z

Cited by 10 publications

(8 citation statements)

References 6 publications

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“…A limitation of their report was that the results were heavily influenced by one large study (Quaranta et al. ; Milea & Aung ). The data supports the hypothesis that the IOP‐independent effect of flavonoids is based on its neuroprotective properties and increase in ocular blood flow.…”

Section: Resultsmentioning

confidence: 99%

“…A systematic review and meta-analysis reported a favourable effect of flavonoids on visual fields in glaucoma patients, but no association of flavonoids with IOP was found (Patel et al 2015). A limitation of their report was that the results were heavily influenced by one large study (Quaranta et al 2003;Milea & Aung 2015). The data supports the hypothesis that the IOPindependent effect of flavonoids is based on its neuroprotective properties and increase in ocular blood flow.…”

Section: Nutrition With Antioxidative Propertiesmentioning

confidence: 94%

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The relation between dietary intake and glaucoma: a systematic review

Ramdas

2018

Acta Ophthalmologica

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Intake of selenium and iron may increase the risk of glaucoma, though, only few studies have been done on this topic. Nitric oxide present in other dark green leafy vegetables seems to have a beneficial effect on glaucoma. However, the evidence for an association of dietary intake with glaucoma is still not strong. More (longitudinal and randomized clinical trials) studies are required to make the presented findings clinically applicable.

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Section: Resultsmentioning

confidence: 99%

Section: Nutrition With Antioxidative Propertiesmentioning

confidence: 94%

The relation between dietary intake and glaucoma: a systematic review

Ramdas

2018

Acta Ophthalmologica

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“…polyphenols, caffeine, and minerals) [ 65 ]. Flavonoids, a major polyphenol in tea, are thought to play a role in glaucoma [ 13 , 66 ] owing to their various physiological actions that are proposed to affect non-IOP-dependent mechanisms. Studies have shown that flavonoids demonstrate their protective effect by reducing oxidative stress [ 67 ] and improving blood flow [ 68 ].…”

Section: Individual Dietary Componentsmentioning

confidence: 99%

The Role of Diet in Glaucoma: A Review of the Current Evidence

Owaifeer

Taisan

2018

Ophthalmol Ther

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Intraocular pressure (IOP) reduction by medications, laser, or surgery remains the mainstay of treatment in glaucoma. However, the role of complementary and alternative medicine (CAM) in glaucoma has received great interest from both patients and ophthalmologists. Previous evidence suggests that diet, a major domain of CAM, can influence an individual’s IOP level. Furthermore, certain dietary components have been linked to the incidence and progression of glaucoma. In this review, we aim to provide a summary of the current evidence regarding the role of obesity, certain dietary components, and dietary supplements in glaucoma.

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“…Interestingly, 15% of the FDA-approved drugs targeting various GPCRs are derived from natural product scaffolds [5]. A diet rich in fruits and vegetables containing polyphenolic compounds has been demonstrated to benefit ocular pathologies, including AMD, glaucoma, and RP [55][56][57][58][59]. These compounds exhibit anti-inflammatory, anti-oxidant, and anti-apoptotic properties (see the next section), but they can also interact directly with rod opsin.…”

Section: Natural Products-derived Compounds As Rhodopsin Modulators Amentioning

confidence: 99%

The Retinoid and Non-Retinoid Ligands of the Rod Visual G Protein-Coupled Receptor

Ortega

Jastrzębska

2019

IJMS

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G protein-coupled receptors (GPCRs) play a predominant role in the drug discovery effort. These cell surface receptors are activated by a variety of specific ligands that bind to the orthosteric binding pocket located in the extracellular part of the receptor. In addition, the potential binding sites located on the surface of the receptor enable their allosteric modulation with critical consequences for their function and pharmacology. For decades, drug discovery focused on targeting the GPCR orthosteric binding sites. However, finding that GPCRs can be modulated allosterically opened a new venue for developing novel pharmacological modulators with higher specificity. Alternatively, focus on discovering of non-retinoid small molecules beneficial in retinopathies associated with mutations in rhodopsin is currently a fast-growing pharmacological field. In this review, we summarize the accumulated knowledge on retinoid ligands and non-retinoid modulators of the light-sensing GPCR, rhodopsin and their potential in combating the specific vision-related pathologies. Also, recent findings reporting the potential of biologically active compounds derived from natural products as potent rod opsin modulators with beneficial effects against degenerative diseases related to this receptor are highlighted here.

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Flavonoids and glaucoma: revisiting therapies from the past

Cited by 10 publications

References 6 publications

The relation between dietary intake and glaucoma: a systematic review

The relation between dietary intake and glaucoma: a systematic review

The Role of Diet in Glaucoma: A Review of the Current Evidence

The Retinoid and Non-Retinoid Ligands of the Rod Visual G Protein-Coupled Receptor

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