Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials

Russo, Benedetta; Picconi, Fabiana; Malandrucco, Ilaria; Frontoni, Simona

doi:10.3390/ijms20092061

Cited by 68 publications

(55 citation statements)

References 93 publications

(107 reference statements)

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“…The total phenolic content (TPC) of Z. latifolia varies from 1698 to 4108 μg/g, with ferulic, sinapic, and vanillic acids being the main compounds [4], which are responsible for a wide range of bioactivities, including antioxidant, antiallergenic, and antimicrobial effects [5,10]. The total flavonoid content (TFC) of Z. latifolia varies from 578 to 791 μg/g and mainly comprises procyanidin, quercetin, and catechin [4], which improve insulin sensitivity and blood glucose homeostasis, inhibit proliferation of tumor cells, and demonstrate antioxidant activity [6,7,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Compounds from Chinese Wild Rice

et al. 2019

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In this study, deep eutectic solvents (DESs) were used for the ultrasound-assisted extraction (UAE) of valuable bioactive compounds from Chinese wild rice (Zizania spp.). To this end, 7 different choline chloride (CC)-based DESs were tested as green extraction solvents. Choline chloride/1,4-butanediol (DES-2) exhibited the best extraction efficiency in terms of parameters such as the total flavonoid content (TFC), total phenolic content (TPC), and free radical scavenging capacity (DPPH● and ABTS●+). Subsequently, the UAE procedure using 76.6% DES-2 was also optimized: An extraction temperature of 51.2 °C and a solid–liquid ratio of 37.0 mg/mL were considered optimal by a Box–Behnken experiment. The optimized extraction procedure proved efficient for the extraction of 9 phenolic and 3 flavonoid compounds from Chinese wild rice as determined by quantification based on ultra-performance liquid chromatography–triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS). This work, thus, demonstrates the possibility of customizing green solvents that offer greater extraction capacity than that of organic solvents.

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Section: Introductionmentioning

confidence: 99%

Optimizing Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Compounds from Chinese Wild Rice

et al. 2019

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“…These molecules are responsible for the major organoleptic characteristics of plant food, such as the visual appearance, flavor, bitterness, astringency, and aroma [64]. Many beneficial effects attributed to phenolic compounds [64,65,66,67] have given rise to a new interest in finding plant species with a high phenolic content and relevant biological activity. Studies on the phenolic compounds of the fruits of maqui, murta, calafate, arrayán, and Chilean strawberry highlight the high antioxidant activity they present [15,16,17,18,19,20,21,22,23] (Table 2).…”

Section: Quality Aspects and Bioactive Compounds Of Patagonian Bermentioning

confidence: 99%

“…Phenolic compounds are effective antioxidants and can display various effects, including anti-microbial, anti-inflammatory, anti-mutagenic, anti-carcinogenic, anti-allergic, anti-platelet, vasodilator, and neuroprotective effects [65,67,118]. These properties have given rise to a new interest in finding plant species with a high phenolic content and relevant biological activity.…”

Section: Healthy Potential Of Patagonian Berriesmentioning

confidence: 99%

“…Metabolic syndrome (MetS) includes several metabolic abnormalities, such as abdominal obesity, hypertension, insulin resistance, and dyslipidemia. MetS has been associated with an increased risk of CVD and type 2 diabetes mellitus (T2DM) [67]. The onset and progression of MetS are mediated by body weight and blood pressure reduction, as well as improvement in insulin-sensitivity and lipid metabolism [119].…”

Section: Healthy Potential Of Patagonian Berriesmentioning

confidence: 99%

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Patagonian Berries: Healthy Potential and the Path to Becoming Functional Foods

Fuentes

Figueroa

Valdenegro

et al. 2019

Foods

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In recent years, there has been an increasing interest in studying food and its derived ingredients that can provide beneficial effects for human health. These studies are helping to understand the bases of the ancestral use of several natural products, including native fruits as functional foods. As a result, the polyphenol profile and the antioxidant capacity of the extracts obtained from different Patagonian native berries have been described. This review aims to provide valuable information regarding fruit quality, its particular compound profile, and the feasibility of producing functional foods for human consumption to prevent disorders such as metabolic syndrome and cardiovascular diseases. We also discuss attempts concerning the domestication of these species and generating knowledge that strengthens their potential as traditional fruits in the food market and as a natural heritage for future generations. Finally, additional efforts are still necessary to fully understand the potential beneficial effects of the consumption of these berries on human health, the application of suitable technology for postharvest improvement, and the generation of successfully processed foods derived from Patagonian berries.

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“…Flavonoids are widely distributed in plants, fulfilling many functions. They may also act as chemical messengers and physiological regulators …”

Section: Flavonoidmentioning

confidence: 99%

New Insights into Bioactive Compounds of Traditional Chinese Medicines for Insulin Resistance Based on Signaling Pathways

Wang

Vijg

2019

Chemistry & Biodiversity

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Type 2 diabetes is a serious metabolic disease as a long‐term threat to human health. Insulin resistance is not only the basis and major feature of type 2 diabetes, but also the main etiology of diseases such as hypertension, hyperlipidemia and coronary heart disease. It has been shown that Traditional Chinese Medicines (TCMs) play an important role in the treatment of type 2 diabetes, through attenuating insulin resistance, whereas the mechanism involved is not yet well understood. Therefore, it is important to elucidate the pharmacological mechanism of these bioactive compounds so that one can pave the way for the modernization of TCMs. In this review, we focus on the recent progresses of some bioactive ingredients from TCMs with different functional groups, which exhibit therapeutic potential for the treatment of diabetic insulin resistance. It is expected that this review can provide new references for developing TCM‐derived drugs against diabetes and insulin resistance in the future.

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Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials

Cited by 68 publications

References 93 publications

Optimizing Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Compounds from Chinese Wild Rice

Optimizing Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Compounds from Chinese Wild Rice

Patagonian Berries: Healthy Potential and the Path to Becoming Functional Foods

New Insights into Bioactive Compounds of Traditional Chinese Medicines for Insulin Resistance Based on Signaling Pathways

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