Flavonoids and other bioactive constituents from Ficus thonningii Blume (Moraceae)

Fongang, Yannick Stéphane Fotsing; Bankeu, Jean Jules Kezetas; Ali, Muhammad; Awantu, Angelbert Fusi; Ahmed, Zeeshan; Assob, Clement Nguedia; Lateef, Mehreen; Lenta, Bruno N.; Ngouela, Silvère; Tsamo, Etienne

doi:10.1016/j.phytol.2014.11.012

Cited by 34 publications

(16 citation statements)

References 15 publications

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“…As a ubiquitous constituent of foods and herbs, taxifolin is consumed regularly in the human diet and exerts a wide range of biochemical and pharmacological effects; these include antioxidant [9,10], antitumor [11] and anti-inflammatory effects [12], the prevention of Alzheimer’s disease [13], antidiabetic [14,15], antiviral [16], antimicrobial [17], hepatoprotective [18], cardioprotective [15,19], neuroprotective [20] and immunoregulatory effects [21], and xanthine oxidase inhibition [22]. Additionally, experimental data indicate that taxifolin use is safe and nontoxic [2,23].…”

Section: Introductionmentioning

confidence: 99%

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

Yang

et al. 2016

Molecules

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Abstract:Taxifolin is a ubiquitous bioactive constituent of foods and herbs. To thoroughly explore its metabolism in vivo, an HPLC-ESI-IT-TOF-MS n method combined with specific metabolite detection strategy was used to detect and identify the metabolites of taxifolin in rats. Of the 191 metabolites tentatively identified, 154 were new metabolites, 69 were new compounds and 32 were dimers. This is the first report of the in vivo biotransformation of a single compound into more than 100 metabolites. Furthermore, acetylamination and pyroglutamic acid conjugation were identified as new metabolic reactions. Seventeen metabolites were found to have various taxifolin-related bioactivities. The potential targets of taxifolin and 63 metabolites were predicted using PharmMapper, with results showing that more than 60 metabolites have the same five targets. Metabolites with the same fragment pattern may have the same pharmacophore. Thus these metabolites may exert the same pharmacological effects as taxifolin through an additive effect on the same drug targets. This observation indicates that taxifolin is bioactive not only in the parent form, but also through its metabolites. These findings enhance understanding of the metabolism and effective forms of taxifolin and may provide further insight of the beneficial effects of taxifolin and its derivatives.

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Section: Introductionmentioning

confidence: 99%

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

Yang

et al. 2016

Molecules

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“…The identification of the chemical composition of HE revealed the presence of compounds with antimicrobial activity, such as taxifolin [49], kaempferol-3-O-rutinoside [50], and isoflavone genistein [51,52]. Polyphenolic compounds are widely studied because they show promising antimicrobial activity and, among them, flavan-3-ols, flavonols, and proanthocyanidins are the most researched because they present a broad spectrum of action and higher antimicrobial activity when compared with other polyphenols [53].…”

Section: Discussionmentioning

confidence: 99%

Maclura tinctoria Extracts: In Vitro Antibacterial Activity against Aeromonas hydrophila and Sedative Effect in Rhamdia quelen

Pires

Rodrigues

Garlet

et al. 2021

Fishes

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Maclura tinctoria is a tree species native from Brazil and rich in phenolic compounds. Since plant antibacterial activity is highly associated with phenolic compound concentration, we aim to evaluate the in vitro antimicrobial activity of different extracts against fish pathogenic bacteria. In addition, some phenolic compounds have central depressant effects and can be useful in aquaculture due to possible sedative and/or anesthetic effects. Four M. tinctoria extracts were extracted separately with ethanol; leaves (LE), bark (BE), heartwood (HE), and the sapwood (SE). In vitro antimicrobial activity was tested against Aeromonas strains at concentrations of 6400 to 3.125 μg/mL. The sedative effect was evaluated for 24 h with 30 and 100 mg/L concentrations. Chemical composition was analyzed by HPLC-DAD-MS. The HE extract had the best MIC (400 µg/mL) and MBC (800 µg/mL) compared to the LE, BE, and SE extracts. LE extract induced deep sedation and the BE, SE, and HE extracts induced light sedation. Additionally, BE, SE, and HE induced a normal behavior without side effects. Polyphenolic compounds with antimicrobial activity and sedative effects were identified mainly in HE. Thus, HE extract is safe and can be used as a sedative for silver catfish.

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“…Several compounds have been isolated from Ficus species which were responsible for their pharmacological activities. Taxifolin, conrauiflavonol and shuterin isolated from F. thonningii exhibited moderate antimicrobial activity against Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, and Staphylococcus aureus [10] . Thonningiisoflavone and hydroxyalpinumisoflavone isolated from F. thonningii and eleutheroside B, morin, quercitrin and myricitrin found in F. elastica displayed strong DPPH radical scavenging activity [10,11] .…”

Section: Introductionmentioning

confidence: 99%

“…Taxifolin, conrauiflavonol and shuterin isolated from F. thonningii exhibited moderate antimicrobial activity against Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, and Staphylococcus aureus [10] . Thonningiisoflavone and hydroxyalpinumisoflavone isolated from F. thonningii and eleutheroside B, morin, quercitrin and myricitrin found in F. elastica displayed strong DPPH radical scavenging activity [10,11] . Ficusoside B isolated from F. elastica wood methanol extract was active against E. coli, P. vulgaris, S. aureus and C. albicans [12] .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Quantitative Analysis and Biological activities of Ficus recurvata (De Wildeman)

2021

JCBSC

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Ficus recurvata (Moraceae) has been used traditionally to treat impotence, cardiac pain, hysteria and hiccups. However, the medicinal importance and secondary metabolites of this specie has been sparsely reported. Hence, we investigated the secondary metabolites, antimicrobial and antioxidant activities of F. recurvata leaf. Dried leaves of F. recurvata (500 g) were pulverized and extracted with ethanol for 72 h by maceration to obtain the ethanol extract (38.36 g) which was partitioned using hexane and ethyl acetate by liquid-liquid extraction to obtain hexane (7.59 g), ethyl acetate (14.34 g) and ethanol (16.44 g) fractions successively. Phytochemical screening of leaf ethanol extract and the fractions were assessed for flavonoids, alkaloids, phenols, tannins, saponins, glycosides, steroids, and terpenoids. Total phenolics, flavonoids, tannins and saponins present in ethanol extract were quantified by spectrophotometric method and alkaloids content by titrimetric method. Antioxidant and antimicrobial activities of ethanol extract and the fractions were evaluated using 2, 2-diphenylpicrylhydrazyl radical (DPPH)* and agar diffusion methods respectively. Total flavonoids, phenolics, tannins, saponins and alkaloids in F. recurvata ethanol extract were 0.145±0.001 mg/g of quercetin equivalent, 0.224±0.005 mg/g of gallic acid equivalent, 0.030±0.001 mg/g of tannic acid equivalent, 1.517±0.189 mg/g of saponin equivalent and 0.373 g of alkaloid respectively. Among the test samples, ethyl acetate fraction showed highest antioxidant activity (IC50=301.82 µg/mL) while the hexane fraction displayed the least activity (IC50=977.58 µg/mL). Ethanol fraction was most active against the microorganisms and Phytochemical… Olaoluwa O. Olaoluwa et al.

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Flavonoids and other bioactive constituents from Ficus thonningii Blume (Moraceae)

Cited by 34 publications

References 15 publications

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

Maclura tinctoria Extracts: In Vitro Antibacterial Activity against Aeromonas hydrophila and Sedative Effect in Rhamdia quelen

Phytochemical Screening, Quantitative Analysis and Biological activities of Ficus recurvata (De Wildeman)

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