Flavonoids and Related Compounds in Parasitic Disease Control

Kerbœuf, Dominique; Riou, Mickaël; Guégnard, Fabrice

doi:10.2174/138955708783498168

Cited by 65 publications

(45 citation statements)

References 79 publications

(119 reference statements)

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“…Our work also indicates that the anthelmintic activity of plants or their products do not depend only on the extract nature (aqueous vs. non-aqueous), but also depends on the concentration used, different chemotypes within the same plant species, and on the target parasitic helminth species. Apart from direct effects attributed to the bioactive compounds artemisinin (A. annua) and acetogenins (A. triloba), evidence is accumulating in favor of antioxidant flavonoids as part of the anthelmintic animal defense, by first maintaining an oxidant/antioxidant equilibrium in the blood or by affecting the parasite directly (Kerboeuf et al 2008;Toner et al 2008), second an indirect modulatory effect on the host immune system (Provenza and Villalba 2010;Zhao et al 2007), with the latter being vital for resilience of parasitized animals, such as goats (Hoste et al 2010;Lightbody et al 2001), and third inhibiting proinflammatory compounds and alleviating inflammatory response caused by a challenged immune system (García-Lafuente et al 2009), a common response in parasitized subjects.…”

Section: Discussionmentioning

confidence: 99%

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In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis

Ferreira¹,

Peaden²,

Keiser

2011

Parasitol Res

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Trematode infections negatively affect human and livestock health, and threaten global food safety. The only approved human anthelmintics for trematodiasis are triclabendazole and praziquantel with no alternative drugs in sight. We tested six crude plant extracts against adult Schistosoma mansoni, Fasciola hepatica, and Echinostoma caproni in vitro. Mortality was best achieved by ethanolic extracts of Artemisia annua (sweet Annie), Asimina triloba (paw-paw), and Artemisia absinthium (wormwood) which, at 2 mg/mL, killed S. mansoni and E. caproni in 20 h or less (except for wormwood), F. hepatica between 16 and 23 h (sweet Annie), or 40 h (paw-paw). Some extracts were active at 0.2 mg/mL and 20 μg/mL, although more time was required to kill trematodes. However, aqueous A. annua and methanol extracts of Fumaria officinalis had no activity. Chromatographic analysis of the three best extracts established that A. annua and A. triloba extracts contained bioactive artemisinin and acetogenins (asimicin and bullatacin), respectively. The anthelmintic activity of our extracts at such low doses indicates that their anthelmintic activity deserves further testing as natural alternative controls for parasites of both animals and humans. Our results also support recent evidence that synergistic effects of multiple bioactive compounds present in crude plant extracts is worth exploring.

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Section: Discussionmentioning

confidence: 99%

“…In addition, direct effects of flavonoids (e.g., genistein, catechin, gallocatechin, etc.) on the trematodes Schistosoma, Opisthorchis, Fasciola hepatica, and Fasciolopsis have been reported (Kerboeuf et al 2008).…”

Section: Introductionmentioning

confidence: 99%

In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis

Ferreira¹,

Peaden²,

Keiser

2011

Parasitol Res

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“…There is no effective vaccine for all these diseases, and its regulation is based on vector control and chemotherapy [8]. The drugs currently used have high toxicity and limited efficacy and demand a long period of treatment [4, 8].…”

Section: Introductionmentioning

confidence: 99%

The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids

Baldim

Alcântara

Domingos

et al. 2017

Oxidative Medicine and Cellular Longevity

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Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development of drug resistance. Thus, a series of 40 flavonoids were investigated with the purpose of correlating these properties via structure and activity analyses based on integrated networks and QSAR models. The classical groups for the antioxidant activity of flavonoids were combined in order to explain the influence of antioxidant and prooxidant activities on the antiparasitic properties. These analyses become useful for the development of efficient treatments for leishmaniasis and trypanosomiasis. Finally, the dual activity of flavonoids presenting both anti- and prooxidant activities revealed that the existence of a balance between these two features could be important to the development of adequate therapeutic strategies.

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“…Anthraquinones, flavonoids, phenols, phlobatannins, polysaccharides, saponins, tannins, and terpenoids have been isolated from the leaf extract of E. prostrata (18). The flavonoids are promising compounds for controlling human and animal parasitic diseases (19). Phenolic compounds were tested against Leishmania spp.…”

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confidence: 99%

Green Synthesis of Silver and Titanium Dioxide Nanoparticles Using Euphorbia prostrata Extract Shows Shift from Apoptosis to G ₀ /G ₁ Arrest followed by Necrotic Cell Death in Leishmania donovani

Zahir¹,

Chauhan

Bagavan³

et al. 2015

Antimicrob Agents Chemother

157

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The aim of the present study was to synthesize silver (Ag) and titanium dioxide (TiO 2 ) nanoparticles (NPs) using green synthesis from aqueous leaf extract of Euphorbia prostrata as antileishmanial agents and to explore the underlying molecular mechanism of induced cell death. In vitro antileishmanial activity of synthesized NPs was tested against promastigotes of Leishmania donovani by alamarBlue and propidium iodide uptake assays. Antileishmanial activity of synthesized NPs on intracellular amastigotes was assessed by Giemsa staining. The leishmanicidal effect of synthesized Ag NPs was further confirmed by DNA fragmentation assay and by cell cycle progression and transmission electron microscopy (TEM) of the treated parasites. TEM analysis of the synthesized Ag NPs showed a spherical shape with an average size of 12.82 ؎ 2.50 nm, and in comparison to synthesized TiO 2 NPs, synthesized Ag NPs were found to be most active against Leishmania parasites after 24 h exposure, with 50% inhibitory concentrations (IC 50 ) of 14.94 g/ml and 3.89 g/ml in promastigotes and intracellular amastigotes, respectively. A significant increase in G 0 /G 1 phase of the cell cycle with a subsequent decrease in S (synthesis) and G 2 /M phases compared to controls was observed. The growth-inhibitory effect of synthesized Ag NPs was attributed to increased length of S phase. A decreased reactive oxygen species level was also observed, which could be responsible for the caspase-independent shift from apoptosis (G 0 /G 1 arrest) to massive necrosis. High-molecular-weight DNA fragmentation as a positive consequence of necrotic cell death was also visualized. We also report that the unique trypanothione/trypanothione reductase (TR) system of Leishmania cells was significantly inhibited by synthesized Ag NPs. The green-synthesized Ag NPs may provide promising leads for the development of costeffective and safer alternative treatment against visceral leishmaniasis.

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Flavonoids and Related Compounds in Parasitic Disease Control

Cited by 65 publications

References 79 publications

In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis

In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis

The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids

Green Synthesis of Silver and Titanium Dioxide Nanoparticles Using Euphorbia prostrata Extract Shows Shift from Apoptosis to G ₀ /G ₁ Arrest followed by Necrotic Cell Death in Leishmania donovani

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Flavonoids and Related Compounds in Parasitic Disease Control

Cited by 65 publications

References 79 publications

In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis

In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis

The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids

Green Synthesis of Silver and Titanium Dioxide Nanoparticles Using Euphorbia prostrata Extract Shows Shift from Apoptosis to G 0 /G 1 Arrest followed by Necrotic Cell Death in Leishmania donovani

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Green Synthesis of Silver and Titanium Dioxide Nanoparticles Using Euphorbia prostrata Extract Shows Shift from Apoptosis to G ₀ /G ₁ Arrest followed by Necrotic Cell Death in Leishmania donovani