Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: A structure–activity relationship study

Sghaïer, Mohamed Ben; Skandrani, Inès; Nasr, Nouha; Franca, Marie-Genviève Dijoux; Chekir‐Ghedira, Leila; Ghédira, Kamel

doi:10.1016/j.etap.2011.07.003

Cited by 110 publications

(78 citation statements)

References 87 publications

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“…28,29 On the other hand, the flavonoids effectively inhibited functional enzymes in inflammatory and cancer pathologies including 5-lipoxygenase, cyclo oxygenase, mono oxygenase and xanthine oxidase. 28,30 The flavonoids also modulated the several proteins that involved in cancer promotion for instance protein kinases, epidermal growth factor receptors, platelet derived growth factor receptors, vascular endothelial growth factor receptors and cyclin-dependent kinases. 28,31 As shown in Figure 4, group A has the highest level of phenolics, while group Chas the lowest level.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties

et al. 2015

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Introduction: Many of Medicinal plants have been investigated for possible anticancer properties. The correlation cytotoxic effect of herbs with antioxidant activity is unclear, yet. The aim of the present study was to examine the antioxidant contents and anticancer effects of 12 Iranian medicinal plants on proliferation of breast cancer, MCF-7, and epithelial normal, MCf-10A, cells. Methods: Free radical scavenging and total antioxidant capacities of herbal waters assessed by DPPH and FRAP methods, respectively. Their total phenolic contents and cell viability determined by Folin-Ciocalteu and MTT assays, respectively. Results: Among the herbs, group A which contained relatively highest total phenolics content, antioxidant and free radical scavenging activities inhibited significantly greater growth of breast cancer cells in a dose-and time-dependent manner as compared to other groups. These medicinal plants were not cytotoxic components against normal cells. Conclusion: Therefore our results indicated that anti proliferative effects of 12 selected Iranian herbs

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Section: Discussionmentioning

confidence: 99%

Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties

et al. 2015

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“…These species are known for their medicinal and biological properties such as hypoglycemic, hypolipidemic, hepatoprotective, antipyretic, anti-inflammatory, antiulcerogenic, antitumor and antimicrobial activities (Rasekh et al 2001;Baluchnejadmojarad et al 2005;Sundaresan et al 2006;Vuković et al 2007;Shtukmaster et al 2010;Sghaier et al 2011a;Sghaier et al 2011b). Many species of this genus show antimicrobial, antioxidant and antifungal activities and are used in food industry (Salah et al 2006;Ozkan et al 2007;Ahmad et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of genotoxicity and antimutagenicity of methanolic extracts from Teucrium chamaedrys and Teucrium montanum in human lymphocytes using micronucleus assay

et al. 2013

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Since Teucrium chamaedrys and Teucrium montanum are the most popular plants used in the treatment of many diseases, we evaluated genotoxic potential of their methanolic extracts on cultured human peripheral blood lymphocytes (PBLs) using cytokinesis-block micronucleus (MN) assay. Cultures were treated with four concentrations of both plants (125, 250, 500 and 1,000 lg/ml), both separately and in combination with mitomycin C (MMC). The results revealed that extract of T. chamaedrys administered at the tested concentrations did not significantly affect the mean MN frequency in comparison to untreated cells. Methanolic extract of T. montanum increased the mean MN frequency in PBL at the tested concentrations, but significantly only at the concentration of 1,000 lg/ml. In all tested concentrations, the extract of T. chamaedrys significantly reduced the MMC-induced MN frequency, in a dose dependent manner (r = -0.687, p \ 0.01). The extract of T. montanum decreased the MMC-induced MN frequency at the tested concentrations, but statistically only at 125 lg/ ml. Both extracts administered alone did not significantly affect the nuclear division index (NDI) at the tested concentrations. In the combined treatments with MMC, the extract obtained from T. chamaedrys in the concentrations of 500 and 1,000 lg/ml significantly decreased NDI values in comparison to MMC-treated cells alone, while the extract of T. montanum significantly decreased NDI at all tested concentrations. Both extracts nonsignificantly decreased NDI at all tested concentrations in comparison to untreated cells. Our results suggest the important function of T. chamaedrys extract in cancer therapy, this methanolic extract may prevent genotoxic effects of chemotherapy in PBLs.

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“…Flavonoids have been shown to exert minimal effects on normal cells with a significant cytotoxic activity against various human cancer cells. This makes flavonoids ideal agents for developing anticancer drugs (Plochmann et al 2007;Ben Sghaier et al 2011). Although most of the biological actions of flavonoids depend on their structure, this point is still unclear for anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Flavonoids ofCalligonum polygonoidesand their cytotoxicity

Ahmed

Moawad

Owis

et al. 2016

Pharmaceutical Biology

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Context Calligonum polygonoides L. subsp. comosum L' Hér. (Polygonaceae), locally known as ''arta'', is a slow-growing small leafless desert shrub. Objective Isolation, structure elucidation and evaluation of cytotoxic activity of flavonoids from C. polygonoides aerial parts. Materials and methods Flavonoids in the hydroalcoholic extract of the of C. polygonoides were isolated and purified using column chromatography and preparative HPLC. The structures of the isolated flavonoids were elucidated on the basis of spectroscopic data including 2D NMR techniques. The cytotoxic activity of the isolated flavonoids (6.25, 25, 50 and 100 mg/mL) was evaluated against liver HepG2 and breast MCF-7 cancer cell lines using sulphorhodamine-B assay.00 -n-butyl glucuronide) (1), and 13 known flavonoids, quercetin 3-O-b-D-(6 00 -n-butyl glucuronide) (2), kaempferol-3-O-b-D-(6 00 -methyl glucuronide) (3), quercetin-3-O-b-D-(6 00 -methyl glucuronide) (4), quercetin-3-O-glucuronide (5), kaempferol-3-O-glucuronide (6), quercetin-3-O-a-rhamnopyranoside (7), astragalin (8), quercetin-3-O-glucopyranoside (9), taxifolin (10), (+)-catechin (11), dehydrodicatechin A (12), quercetin (13), and kaempferol (14), were isolated from the aerial parts of C. polygonoides. Quercetin showed significant cytotoxic activity against HepG2 and MCF-7 cell lines with IC 50 values of 4.88 and 0.87 mg/mL, respectively. Structure-activity relationships were analyzed by comparing IC 50 values of several pairs of flavonoids differing in one structural element. Discussion and conclusion The activity against breast cancer cell lines decreased by glycosylation at C-3. The presence of 2,3-double bond in ring C, carbonyl group at C-4 and 3',4'-dihydroxy substituents in ring B are essential structural requirements for the cytotoxic activity against breast cancer cells. ARTICLE HISTORY

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Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: A structure–activity relationship study

Cited by 110 publications

References 87 publications

Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties

Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties

Comparative study of genotoxicity and antimutagenicity of methanolic extracts from Teucrium chamaedrys and Teucrium montanum in human lymphocytes using micronucleus assay

Flavonoids ofCalligonum polygonoidesand their cytotoxicity

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