Flavonoids and tannins: plant-based antioxidants with vitamin character

Hässig, A.; Linag, W.X.; Schwabl, Herbert; Stampfli, K

doi:10.1054/mehy.1997.0686

Cited by 57 publications

(35 citation statements)

References 13 publications

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“…According to Ng et al (2000) flavonoid compounds exhibit antioxidant and free radical scavenging properties. Flavonoids are also considered as a protective substance against harmful external influences ( Hassig et al 1999). Galvao et al (2002) listed flavonoid glycosides among the substances present on H. tomentosa root extract.…”

Section: Discussionmentioning

confidence: 99%

The effects of Cyclosporin A and Heteropterys tomentosaon the rat liver

Freitas

Almeida

Monteiro

et al. 2015

An. Acad. Bras. Ciênc.

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Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosa is a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa (administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosa infusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosa administered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H. tomentosa administration did not alter the parameters analyzed. Biochemical plasma dosages and liver stereology showed impairment caused by CsA-treatment after 21 days; these results were not observed after 56 days of treatment. The simultaneous treatment with CsA and H. tomentosa for 21 or 56 days did not alleviate nor accentuate CsA hepatic effects. The present study showed that the 21 days treatment with CsA caused more alteration to the liver than the 56 days treatment; this could be related to hepatic recovery after the long term treatment.

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Section: Discussionmentioning

confidence: 99%

The effects of Cyclosporin A and Heteropterys tomentosaon the rat liver

Freitas

Almeida

Monteiro

et al. 2015

An. Acad. Bras. Ciênc.

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“…), and high levels of antioxidant vitamins would appear beneficial. However, Herbert (1994) and Haessig et al (1999) state that the success of conventional vitamin supplementation is especially questionable in humans with high hepatic iron loads, and the latter authors emphasize the antioxidant effects of polyphenols (flavonoids/tannins) in excessive iron storage. Polyphenolic compounds prevent iron-associated oxidative damage very efficiently (Kuehnau, 1976;Cook and Samman, 1996;Bravo, 1998).…”

Section: Discussionmentioning

confidence: 99%

Fat Soluble Vitamins in Blood and Tissues of Free-Ranging and Captive Rhinoceros

Clauß

Jessup

Norkus

et al. 2002

Journal of Wildlife Diseases

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ABSTRACT. Several disease syndromes in captive rhinoceroses have been linked to low vitamin status. Blood samples from captive and free-ranging black (Diceros bicornis) and white rhinoceros (Ceratotherium simum) and tissue samples of captive individuals from four rhinoceros species were analysed for vitamins A and E. Circulating vitamin A levels measured as retinol for freeranging versus captive black and white rhinoceros were 0.04 (Ϯ0.03 SD) vs. 0.08 (Ϯ0.08) and 0.07 (Ϯ0.04) vs. 0.06 (Ϯ0.02) g/ml, respectively. Circulating vitamin E levels measured as ␣-tocopherol were 0.58 (Ϯ0.30) vs. 0.84 (Ϯ0.96) and 0.62 (Ϯ0.48) vs. 0.77 (Ϯ0.32) g/ml, respectively. In contrast to earlier findings, there was no significant difference in vitamin E concentration between captive and free-ranging black rhinoceros. When the samples of captive black rhinoceros were grouped into those taken before 1990 and after 1990, however, those collected before 1990 had significantly lower (P Ͻ 0.001) vitamin E levels (0.46 Ϯ 0.83 g/ml) and those collected in 1990 or later significantly higher (P Ͻ 0.001) vitamin E levels (1.03 Ϯ 1.04 g/ml) than the captive population as a whole. This is probably due to increased dietary supplementation. There were significant differences in circulating vitamin concentrations in black rhinoceroses from different regions in the wild. Serum 25-hydroxy (OH) vitamin D 3 averaged 55.7 ng/ml in freeranging rhinoceroses; no carotenoids were detected in any blood samples. Captive black and white rhinoceroses appear to be adequately supplemented in vitamin A and E. Captive Indian rhinoceroses (Rhinoceros unicornis) had significantly lower vitamin A concentrations in blood (P Ͻ 0.001) and higher vitamin A concentrations in liver tissue samples (P Ͻ 0.001) than other rhinoceros species. Equine requirements are not recommended as a model for rhinoceros vitamin requirements.

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“…In contrast to antibiotics these products do not have side effects and are very useful in food chain. One of the regarded candidates in natural products is flavonoids, which are naturally produced in plants (Croft, 1998;Hassig et al, 1999) and is stored in different forms such as propolis (Giurgea et al, 1981;Dobrowolski, et al, 1991). Propolis or bee glue i s collected by bee which is rich in polyphenols, flavonoids, phenolic acids, cafeic acid and their related esters.…”

Section: Introductionmentioning

confidence: 99%