2006
DOI: 10.1093/jn/136.6.1477
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Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide Vascular Endothelial Growth Factor from Human Tumor Cells

Abstract: Neoangiogenesis is required for tumor development and progression. Many solid tumors induce vascular proliferation by production of angiogenic factors, prominently vascular endothelial growth factor (VEGF). Because nutrition is a causative factor for tumor prevention and promotion, we determined whether secondary plant constituents, i.e., flavonoids, tocopherols, curcumin, and other substances regulate VEGF in human tumor cells in vitro. VEGF release (concurrent with synthesis) from MDA human breast cancer cel… Show more

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Cited by 169 publications
(107 citation statements)
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“…Quercetin, myricetin, kaempferol and galanin were able to suppress the VEGF-stimulated HUVEC tubular structure formation and to inhibit the activated U937 monocytic cell adhesion to HUVEC cells, playing an important role in the prevention of angiogenesis [148]. Schindler and Mentleiny [149] have reported that flavonoids reduced the release of VEGF from human breast cancer cells, being the order of the inhibitory potency as follows: naringin A rutin A apigenin A genistein A kaempferol. Delphinidin also inhibited VEGF-induced migration and proliferation through the blockade of cell cycle in G0/G1 phase (increased expression of p21, p27 and reduced levels of cyclin D1, cyclin A) [150].…”
Section: Antiangiogenesismentioning
confidence: 99%
“…Quercetin, myricetin, kaempferol and galanin were able to suppress the VEGF-stimulated HUVEC tubular structure formation and to inhibit the activated U937 monocytic cell adhesion to HUVEC cells, playing an important role in the prevention of angiogenesis [148]. Schindler and Mentleiny [149] have reported that flavonoids reduced the release of VEGF from human breast cancer cells, being the order of the inhibitory potency as follows: naringin A rutin A apigenin A genistein A kaempferol. Delphinidin also inhibited VEGF-induced migration and proliferation through the blockade of cell cycle in G0/G1 phase (increased expression of p21, p27 and reduced levels of cyclin D1, cyclin A) [150].…”
Section: Antiangiogenesismentioning
confidence: 99%
“…15 It has been reported that naringin could inhibit the growth potential of breast cancer cells by modulating β-catenin pathway. 16,17 This drug (200 mg/kg) suppressed proliferation and increased apoptosis of colon epithelial cells. 15 Naringin (40 mg/kg) exhibited significant protection in N-nitrosodiethylamine-induced liver carcinogenesis in rats.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, the anticancer properties of apigenin in animals have been demonstrated by inhibition of tumor initiation induced by various carcinogens [21,22]. Apigenin has been shown to suppress angiogenesis in melanoma and carcinoma of the breast, skin, and colon [23][24][25][26]. Apigenin is a potent inhibitor of several protein tyrosine kinases, including epidermal growth factor receptor and Src tyrosine kinase [27,28].…”
mentioning
confidence: 99%