Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects

Faysal, Md.; Dehbia, Zerrouki; Zehravi, Mehrukh; Sweilam, Sherouk Hussein; Haque, M. Akiful; Kumar, Kusuma Praveen; Chakole, Rita D.; Shelke, Satish P.; Sirikonda, Swapna; Nafady, Mohamed H.; Khan, Sharuk L.; Nainu, Firzan; Ahmad, Irfan; Emran, Talha Bin

doi:10.1007/s11064-024-04177-x

Neurochem Res

2024

DOI: 10.1007/s11064-024-04177-x

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Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects

Md. Faysal,

Zerrouki Dehbia,

Mehrukh Zehravi

et al.

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Cited by 4 publications

References 140 publications

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A critical appraisal of geroprotective activities of flavonoids in terms of their bio-accessibility and polypharmacology

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Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations

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Sârb,

Drăghici

et al. 2024

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Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, the brain’s ability to adapt its structure and function, plays a crucial role in mitigating MS’s impact. This paper explores the potential benefits of lifestyle changes and nutraceuticals on brain plasticity in the MS population. Lifestyle modifications, including physical activity and dietary adjustments, can enhance brain plasticity by upregulating neurotrophic factors, promoting synaptogenesis, and reducing oxidative stress. Nutraceuticals, such as vitamin D, omega-3 fatty acids, and antioxidants like alpha lipoic acid, have shown promise in supporting brain health through anti-inflammatory and neuroprotective mechanisms. Regular physical activity has been linked to increased levels of brain-derived neurotrophic factor and improved cognitive function. Dietary interventions, including caloric restriction and the intake of polyphenols, can also positively influence brain plasticity. Integrating these lifestyle changes and nutraceuticals into the management of MS can provide a complementary approach to traditional therapies, potentially improving neurological outcomes and enhancing the quality of life for the MS population.

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Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects

Cited by 4 publications

References 140 publications

Comprehensive study on Malus ‘Donald Wyman’ crabapple extract: Its characterization, impact on chitosan film properties, and preservation efficacy in grapes

Comprehensive study on Malus ‘Donald Wyman’ crabapple extract: Its characterization, impact on chitosan film properties, and preservation efficacy in grapes

A critical appraisal of geroprotective activities of flavonoids in terms of their bio-accessibility and polypharmacology

Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations

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