Flavonoids as receptor tyrosine kinase inhibitors in lung cancer

Sudhesh Dev, Sareshma; Farghadani, Reyhaneh; Zainal Abidin, Syafiq Asnawi; Othman, Iekhsan; Naidu, Rakesh

doi:10.1016/j.jff.2023.105845

Cited by 5 publications

(1 citation statement)

References 267 publications

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“…They are abundant in fruits, vegetables, and medicinal herbs. Quercetin (found in apples, onions), epicatechin (abundant in green tea, cocoa), and hesperidin (citrus fruits) are prominent flavonoids with notable antioxidant effects [29,30]. -Alkaloids: e a diverse group of nitrogen-containing compounds with varying pharmacological activities.…”

Section: Key Medicinal Plant Compounds Known For Their Antioxidant Pr...mentioning

confidence: 99%

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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The paper provides a comprehensive examination of heavy metal stress on medicinal plants, focusing on its impact on antioxidant capacity and biosynthetic pathways critical to their therapeutic potential. It explores the complex relationship between heavy metals and the physiological and biochemical responses of medicinal plants, highlighting how metal stress disrupts biosynthetic pathways, altering concentrations of secondary metabolites. This disruption may compromise the overall quality and efficacy of medicinal plants, requiring a holistic understanding of its cumulative impacts. Furthermore, the study discusses the potential of targeted genetic editing to enhance plant resilience against heavy metal stress by manipulating genes associated with antioxidant defenses. This approach represents a promising frontier in safeguarding medicinal plants in metal-contaminated environments. Additionally, the research investigates the role of phytohormone signaling in plant adaptive mechanisms to heavy metal stress, revealing its influence on biochemical and physiological responses, thereby adding complexity to plant adaptation. The study underscores the importance of innovative technologies and global cooperation in protecting medicinal plants’ therapeutic potential and highlights the need for mitigation strategies to address heavy metal contamination effectively.

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Section: Key Medicinal Plant Compounds Known For Their Antioxidant Pr...mentioning

confidence: 99%

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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A comprehensive review on the potential applications of medicine Polygonatum species in the food sector

Li,

Xie,

et al. 2024

Food Bioscience

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Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine

Zahra,

Abrahamse,

George

2024

Antioxidants

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This study emphasizes the critical role of antioxidants in protecting human health by counteracting the detrimental effects of oxidative stress induced by free radicals. Antioxidants—found in various forms such as vitamins, minerals, and the phytochemicals abundant in fruits and vegetables—neutralize free radicals by stabilizing them through electron donation. Specifically, flavonoid compounds are highlighted as robust defenders, addressing oxidative stress and inflammation to avert chronic illnesses like cancer, cardiovascular diseases, and neurodegenerative diseases. This research explores the bioactive potential of flavonoids, shedding light on their role not only in safeguarding health, but also in managing conditions such as diabetes, cancer, cardiovascular diseases, and neurodegenerative diseases. This review highlights the novel integration of South African-origin flavonoids with nanotechnology, presenting a cutting-edge strategy to improve drug delivery and therapeutic outcomes. This interdisciplinary approach, blending traditional wisdom with contemporary techniques, propels the exploration of flavonoid-mediated nanoparticles toward groundbreaking pharmaceutical applications, promising revolutionary advancements in healthcare. This collaborative synergy between traditional knowledge and modern science not only contributes to human health, but also underscores a significant step toward sustainable and impactful biomedical innovations, aligning with principles of environmental conservation.

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Flavonoids as receptor tyrosine kinase inhibitors in lung cancer

Cited by 5 publications

References 267 publications

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

A comprehensive review on the potential applications of medicine Polygonatum species in the food sector

Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine

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