Flavonoids – Food Sources, Health Benefits, and Mechanisms Involved

Kozłowska, Aleksandra; Szostak-Węgierek, Dorota

doi:10.1007/978-3-319-78030-6_54

Cited by 34 publications

(19 citation statements)

References 109 publications

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“…The study of anti-inflammatory effects of natural compounds in DCM is on the rise in pre-clinical and clinical research. An adequate diet has demonstrated a significant implication for maintaining cardiac function in patients with diabetes ( Kozlowska, 2017 ; Allen et al, 2019 ). For instance, quercetin, a flavonoid, lowers systolic blood pressure in type 2 diabetic women without a positive effect on inflammatory biomarkers contradictory to pre-clinical data ( Rivera et al, 2008 ; Roslan et al, 2017 ), possibly due to small sample size recruitment ( Zahedi et al, 2013 ).…”

Section: Therapeutic Strategies For Prevention Of Dcm By Targeting Inflammationmentioning

confidence: 99%

Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response

et al. 2021

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The incidence of heart failure (HF) continues to increase rapidly in patients with diabetes. It is marked by myocardial remodeling, including fibrosis, hypertrophy, and cell death, leading to diastolic dysfunction with or without systolic dysfunction. Diabetic cardiomyopathy (DCM) is a distinct myocardial disease in the absence of coronary artery disease. DCM is partially induced by chronic systemic inflammation, underpinned by a hostile environment due to hyperglycemia, hyperlipidemia, hyperinsulinemia, and insulin resistance. The detrimental role of leukocytes, cytokines, and chemokines is evident in the diabetic heart, yet the precise role of inflammation as a cause or consequence of DCM remains incompletely understood. Here, we provide a concise review of the inflammatory signaling mechanisms contributing to the clinical complications of diabetes-associated HF. Overall, the impact of inflammation on the onset and development of DCM suggests the potential benefits of targeting inflammatory cascades to prevent DCM. This review is tailored to outline the known effects of the current anti-diabetic drugs, anti-inflammatory therapies, and natural compounds on inflammation, which mitigate HF progression in diabetic populations.

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Section: Therapeutic Strategies For Prevention Of Dcm By Targeting Inflammationmentioning

confidence: 99%

Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response

et al. 2021

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“…Indeed, numerous in vitro and in vivo studies have reported the ability of flavonoids to interfere in different stages of carcinogenesis like migration, invasion, metastasis, and angiogenesis (Ravishankar et al, 2013). Moreover, epidemiological studies have shown that long-term and regular consumption of dietary items rich in flavonoids, such as fruits and vegetables, are associated with the lower risk of malignancy developments (Batra & Sharma, 2013;Kozlowska & Szostak-Wegierek, 2014;Tena et al, 2013). The daily intake of flavonoids among humans is still greatly variable, ranging from about twenty milligrams to virtually one gram (Jaramillo-Carmona et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…The daily intake of flavonoids among humans is still greatly variable, ranging from about twenty milligrams to virtually one gram (Jaramillo-Carmona et al, 2014). Although, flavonoids are characterized by a common skeleton of diphenyl propane, they can be further subdivided into flavanols, flavonols, flavones, flavanones, isoflavones and anthocyanins based on the peculiarities in their chemical structures (Batra & Sharma, 2013;Kozlowska & Szostak-Wegierek, 2014;Sak, 2014;Tena et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Kaempferol – A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements

Kashyap

Sharma

Tuli

et al. 2017

Journal of Functional Foods

177

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a b s t r a c tThe consumption of diet-based naturally bioactive metabolites is preferred to synthetic material in order to avert health-associated disorders. Among the plant-derived polyphenols, kaempferol (KMF) is considered as a valuable functional food ingredient with a broad range of therapeutic applications such as anti-cancer, antioxidant and anti-inflammatory uses. KMF acts on a range of intracellular as well as extracellular targets involved in the cell signaling pathways that in turn are known to regulate the hallmarks of cancer growth progressions like apoptosis, cell cycle, invasion or metastasis, angiogenesis and inflammation. Importantly, the understanding of mechanisms of action of KMF-mediated therapeutic effects may help the scientific community to design novel strategies for the treatment of dreadful diseases. The current review summarizes the various types of molecular targets of KMF in cancer cells as well as other health-associated disorders. In addition, this review also highlights the absorption, metabolism and epidemiological findings.

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“…Along with exogenous factors, regular metabolism of oxygen inside the tissues and cells produce reactive oxygen species (ROS) and free radicals that steadily endanger them (Forrester et al, 2018;. Flavonoids are well-recognized for their antioxidant properties and are also confirmed to show beneficial effects in several chronic diseases, including neurodegenerative disease, diabetes, atherosclerosis, and cancer (de Teles et al, 2018;Kozłowska and Szostak-Węgierek, 2019;Uddin et al, 2020c,d). Moreover, certain flavonoids play a crucial role in the iron chelation thus stopping the development of free radicals (Nelson et al, 1992;Ferrali et al, 1997).…”

Section: Effect Of Flavonoids On Other Neuropathic Pain Signaling Patmentioning

confidence: 99%

Exploring the Promise of Flavonoids to Combat Neuropathic Pain: From Molecular Mechanisms to Therapeutic Implications

et al. 2020

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Neuropathic pain (NP) is the result of irregular processing in the central or peripheral nervous system, which is generally caused by neuronal injury. The management of NP represents a great challenge owing to its heterogeneous profile and the significant undesirable side effects of the frequently prescribed psychoactive agents, including benzodiazepines (BDZ). Currently, several established drugs including antidepressants, anticonvulsants, topical lidocaine, and opioids are used to treat NP, but they exert a wide range of adverse effects. To reduce the burden of adverse effects, we need to investigate alternative therapeutics for the management of NP. Flavonoids are the most common secondary metabolites of plants used in folkloric medicine as tranquilizers, and have been claimed to have a selective affinity to the BDZ binding site. Several studies in animal models have reported that flavonoids can reduce NP. In this paper, we emphasize the potentiality of flavonoids for the management of NP.

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Flavonoids – Food Sources, Health Benefits, and Mechanisms Involved

Cited by 34 publications

References 109 publications

Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response

Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response

Kaempferol – A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements

Exploring the Promise of Flavonoids to Combat Neuropathic Pain: From Molecular Mechanisms to Therapeutic Implications

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