Flavonoids from dark chocolate and (−)-epicatechin ameliorate high-fat diet-induced decreases in mobility and muscle damage in aging mice

Munguía, Levy; Ramírez-Sánchez, Israel; Meaney, Eduardo; Villarreal, Francisco; Ceballos, Guillermo; Nájera, Nayelli

doi:10.1016/j.fbio.2020.100710

Cited by 16 publications

(36 citation statements)

References 26 publications

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“…Flavanols such as epicatechin have delayed skeletal muscle degeneration in aged mice by reversing the age-altered expression of extracellular matrix peroxisome proliferator-activated receptors (PPARs), which are master regulators for lipid and glucose homeostasis in muscle [ 81 , 82 ]. Furthermore, epicatechin from cocoa beans improves physical performance consistently with the modulation of biomarkers of sarcopenia by decreasing FoxO1A and MuRF1, regulators of muscle degradation [ 83 ]. Epicatechin has also been shown to have anti-inflammatory effects in diverse cell types, such as hepatic and glial cells, but this effect remains to be proved in sarcopenia [ 117 , 118 ].…”

Section: Other Therapeutic Approaches For Sarcopeniamentioning

confidence: 99%

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Jiménez-Gutiérrez

Martínez-Gómez

Martínez-Armenta

et al. 2022

Cells

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Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is also related to chronic diseases such as metabolic dysfunction associated with diabetes and obesity. This means that everyone will be vulnerable to sarcopenia at some point in their life. Research to find the precise molecular mechanisms implicated in this condition can increase knowledge for the better prevention, diagnosis, and treatment of sarcopenia. Our work gathered the most recent research regarding inflammation in sarcopenia and new therapeutic agents proposed to target its consequences in pyroptosis and cellular senescence. Finally, we compared dual X-ray absorptiometry (DXA), magnetic resonance imaging (MRI), and ultrasound (US) as imaging techniques to diagnose and follow up on sarcopenia, indicating their respective advantages and disadvantages. Our goal is for the scientific evidence presented here to help guide future research to understand the molecular mechanisms involved in sarcopenia, new treatment strategies, and their translation into clinical practice.

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Section: Other Therapeutic Approaches For Sarcopeniamentioning

confidence: 99%

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Jiménez-Gutiérrez

Martínez-Gómez

Martínez-Armenta

et al. 2022

Cells

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“…In high-fat (HF) diet-induced aged mice, EC attenuated muscle damage by reducing the expression of Foxo1 and MuRF-1. Moreover, it boosted physical performance and prompted the growth and differentiation factor MEF2A [ 59 ]. We reported previously that EC treatment suppressed the expression of the ubiquitin ligases atrogin-1 and MuRF-1 induced by 3D clinorotation in C2C12 myoblasts and myotubes via the dephosphorylation of extracellular regulated kinase (ERK) signaling [ 60 ].…”

Section: Polyphenols In Managing Muscle Atrophy and Muscle Healthmentioning

confidence: 99%

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

2021

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Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, and steroidal medications, can cause muscle atrophy. Mechanistically, inflammation, oxidative stress, and mitochondrial dysfunction are among the major contributors to muscle atrophy, by modulating signaling pathways that regulate muscle homeostasis. To prevent muscle catabolism and enhance muscle anabolism, several natural and synthetic compounds have been investigated. Recently, polyphenols (i.e., natural phytochemicals) have received extensive attention regarding their effect on muscle atrophy because of their potent antioxidant and anti-inflammatory properties. Numerous in vitro and in vivo studies have reported polyphenols as strongly effective bioactive molecules that attenuate muscle atrophy and enhance muscle health. This review describes polyphenols as promising bioactive molecules that impede muscle atrophy induced by various proatrophic factors. The effects of each class/subclass of polyphenolic compounds regarding protection against the muscle disorders induced by various pathological/physiological factors are summarized in tabular form and discussed. Although considerable variations in antiatrophic potencies and mechanisms were observed among structurally diverse polyphenolic compounds, they are vital factors to be considered in muscle atrophy prevention strategies.

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“…30,31 Furthermore, Epi increased the expression of growth-regulating proteins and muscle differentiation in obese mice induced by a HFD. 32 To our knowledge, there are no reports in the literature related to the expression of irisin or genes related to thermogenesis in skeletal muscle in the context of induced obesity.…”

Section: Discussionmentioning

confidence: 98%

(-)-epicatechin treatment did not modify the thermogenic pathway in the gastrocnemius muscle of male rat offspring obeses by programming

Tejeda,

De los Santos,

Coral-Vázquez

et al. 2024

J Dev Orig Health Dis

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The aim of this study was to analyse the expression of genes related to the regulation of energy metabolism in skeletal muscle tissue by comparing male offspring in two age groups [at 110 and 245 postnatal days (pnd)] from a mother with obesity induced by a high-fat diet and (-)-epicatechin (Epi) administration. Four groups of six male offspring from different litters were randomly selected for the control groups [C and offspring of mothers with maternal obesity (MO)] or Epi intervention groups. We evaluated the effect of Epi on gastrocnemius tissue by analysing the mRNA and protein expression levels of Fndc5/irisin, Pgc-1α, Ucp3, and Sln. Epi significantly increased the Pgc-1α protein in the MO group of offspring at 110 pnd (p < 0.036, MO vs. MO+Epi), while at 245 pnd, Epi increased Fndc5/irisin mRNA expression in the MO+Epi group versus the MO group (p = 0.006). No differences were detected in Fndc5/irisin, Ucp3 or Sln mRNA or protein levels (including Pgc-1α mRNA) in the offspring at 110 pnd or in Pgc-1α, Ucp3, or Sln mRNA or protein levels (including Fndc5/irisin protein) at 245 pnd among the experimental groups. In conclusion, (-)-epicatechin treatment increased Fndc5/irisin mRNA expression and Pgc-α protein levels in the gastrocnemius muscle of offspring at postnatal days 110 and 245. Furthermore, it is suggested that the flavonoid effect in a model of obesity and its impact on thermogenesis in skeletal muscle are regulated by a different pathway than Fndc5/irisin.

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Flavonoids from dark chocolate and (−)-epicatechin ameliorate high-fat diet-induced decreases in mobility and muscle damage in aging mice

Cited by 16 publications

References 26 publications

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

(-)-epicatechin treatment did not modify the thermogenic pathway in the gastrocnemius muscle of male rat offspring obeses by programming

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